scholarly journals Evaluation of genetic heterogeneity in glutamate carboxypeptidase II (H475Y) and reduced folate carrier (SLC19A1) gene variants increased risk factor for the development of neural tube defects in eastern region of India

2012 ◽  
Vol 4 (1) ◽  
pp. 10-15
Author(s):  
Kumar Saxena
Keyword(s):  
Risk Factor ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Genetic Heterogeneity ◽  
Eastern Region ◽  
Gene Variants ◽  
Reduced Folate Carrier ◽  
Glutamate Carboxypeptidase Ii ◽  
Increased Risk ◽  
Glutamate Carboxypeptidase

Reduced folate carrier gene is a risk factor for neural tube defects in a Chinese population

2005 ◽  
Vol 73 (6) ◽  
pp. 430-433 ◽  
Author(s):  
Lijun Pei ◽  
Huiping Zhu ◽  
Aiguo Ren ◽  
Zhiwen Li ◽  
Ling Hao ◽  
...  
Keyword(s):  
Risk Factor ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Population ◽  
Reduced Folate Carrier

Tea Drinking as a Risk Factor for Neural Tube Defects in Northern China

Epidemiology ◽  
2011 ◽  
Vol 22 (4) ◽  
pp. 491-496 ◽  
Author(s):  
Rongwei Ye ◽  
Aiguo Ren ◽  
Le Zhang ◽  
Zhiwen Li ◽  
Jianmeng Liu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Northern China ◽  
Tea Drinking

Is mutated MTHFR a risk factor for neural tube defects?

The Lancet ◽  
1996 ◽  
Vol 347 (9002) ◽  
pp. 686-687 ◽  
Author(s):  
DrewL. Posey ◽  
MuinJ. Khoury ◽  
Joseph Mulinare ◽  
MyronJ. Adams ◽  
Chin-Yih Ou
Keyword(s):  
Risk Factor ◽  
Neural Tube ◽  
Neural Tube Defects

scholarly journals PREVALENCE OF GLUTAMATE CARBOXYPEPTIDASE II C1561T, REDUCED FOLATE CARRIER 1 A80G, AND METHIONINE SYNTHASE A2756G GENE POLYMORPHISMS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AMONG SOUTH INDIANS

2019 ◽  
pp. 170-175 ◽  
Author(s):  
NITHYA K ◽  
ANGELINE T ◽  
PRISCILLA AS ◽  
ASIRVATHAM AJ
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Methionine Synthase ◽  
Diabetic Patients ◽  
Reduced Folate Carrier ◽  
Increased Risk ◽  
Glutamate Carboxypeptidase

Objective: Glutamate carboxypeptidase II (GCPII), reduced folate carrier 1 (RFC1), and methionine synthase (MTR) genes involved in the folate metabolic pathway may play a key role in the pathogenesis of diabetes and its complications. The present study aimed to investigate the prevalence of genetic polymorphisms of GCPII C1561T, RFC1 A80G, and MTR A2756G in individuals with type 2 diabetes mellitus (T2DM) among South Indians. Methods: The study subjects consisted of 100 healthy individuals and 200 patients with T2DM. Genetic polymorphisms (GCPII C1561T, RFCI A80G, and MTR A2756G) in the folate metabolic pathway were analyzed by polymerase chain reaction-restriction fragment length polymorphism method. Statistical analysis was performed to test the level of significance. Results: With regard to GCPII C1561T and MTR A2756G gene polymorphisms, significant differences were not found when diabetic patients (with and without complications) and controls were compared according to different statistical models (dominant, recessive, and overdominant) p>0.05. A case–control genetic association analysis of RFC1 A80G gene polymorphism has shown that there was 3.7-fold increased risk for patients without complications and 4.9-fold increased risk for diabetic patients with complications. Conclusions: Our findings suggest that the GCPII C1561T and MTR A2756G gene polymorphisms were not significantly associated with diabetes and its complications. Whereas, the RFCI A80G gene polymorphism involved in folate metabolism confers increased risk for diabetes and its complications in South Indian population.

Fetal Repair of Open Neural Tube Defects: Ethical, Legal, and Social Issues

2019 ◽  
Vol 28 (3) ◽  
pp. 476-487 ◽  
Author(s):  
JULIA A.E. RADIC ◽  
JUDY ILLES ◽  
PATRICK J. MCDONALD
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Ethical Issues ◽  
Social Issues ◽  
Controlled Trial ◽  
Fetal Surgery ◽  
Close Monitoring ◽  
Neurologic Outcomes ◽  
Increased Risk ◽  
Fetal Repair

Abstract:Open neural tube defects or myelomeningoceles are a common congenital condition caused by failure of closure of the neural tube early in gestation, leading to a number of neurologic sequelae including paralysis, hindbrain herniation, hydrocephalus and neurogenic bowel and bladder dysfunction. Traditionally, the condition was treated by closure of the defect postnatally but a recently completed randomized controlled trial of prenatal versus postnatal closure demonstrated improved neurologic outcomes in the prenatal closure group. Fetal surgery, or more precisely maternal-fetal surgery, raises a number of ethical issues that we address including who the patient is, informed consent, surgical innovation and equipoise as well maternal assumption of risk. As the procedure becomes more widely adopted into practice, we suggest close monitoring of new fetal surgery centers, in order to ensure that the positive results of the trial are maintained without increased risk to both the mother and fetus.

Fumonisin Inhibition of Ceramide Synthase: A Possible Risk Factor for Human Neural Tube Defects

2006 ◽  
pp. 345-361 ◽  
Author(s):  
Ronald T. Riley ◽  
Kenneth A. Voss ◽  
Marcy Speer ◽  
Victoria L. Stevens ◽  
Janee Gelineau-van Waes
Keyword(s):  
Risk Factor ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Ceramide Synthase
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