scholarly journals A prospective study on assessment of clinically potential drug-drug interactions in hospital and community pharmacy prescriptions

2021 ◽  
Vol 15 (6) ◽  
pp. 118-125
Author(s):  
Kabakama Clement ◽  
Pydimarri Rangadham ◽  
Ponnusankar Sivasankaran
Keyword(s):  
Prospective Study ◽  
Drug Interactions ◽  
Community Pharmacy ◽  
Potential Drug ◽  
A Prospective Study ◽  
Pharmacy Prescriptions

scholarly journals Drug-Drug Interactions in Patients Treated for Cancer: a Prospective Study on Clinical Interventions

2014 ◽  
Vol 25 ◽  
pp. iv162
Author(s):  
R.W. van Leeuwen ◽  
F.G.A. Jansman ◽  
P.M.L.A. van den Bemt ◽  
F. De Man ◽  
F. Piran ◽  
...  
Keyword(s):  
Prospective Study ◽  
Drug Interactions ◽  
Clinical Interventions ◽  
A Prospective Study

scholarly journals Drug–drug interactions in patients treated for cancer: a prospective study on clinical interventions

2015 ◽  
Vol 26 (5) ◽  
pp. 992-997 ◽  
Author(s):  
R.W.F. van Leeuwen ◽  
F.G.A. Jansman ◽  
P.M.L.A. van den Bemt ◽  
F. de Man ◽  
F. Piran ◽  
...  
Keyword(s):  
Prospective Study ◽  
Drug Interactions ◽  
Clinical Interventions ◽  
A Prospective Study

scholarly journals Potential Drug-Drug and Herb-Drug Interactions in Patients With Cancer: A Prospective Study of Medication Surveillance

2017 ◽  
Vol 13 (7) ◽  
pp. e613-e622 ◽  
Author(s):  
Allan Ramos-Esquivel ◽  
Álvaro Víquez-Jaikel ◽  
Cristina Fernández
Keyword(s):  
High Risk ◽  
Prospective Study ◽  
Drug Interactions ◽  
Anticancer Therapy ◽  
Herbal Supplement ◽  
Herbal Supplements ◽  
Patients With Cancer ◽  
Clinical Consequences ◽  
Clinically Significant ◽  
A Prospective Study

Purpose: Patients with cancer frequently use herbal supplements and concomitant medications along with antineoplastic agents. These patients are at high risk of herb-drug interactions (HDIs) and drug-drug interactions (DDIs). We aimed to determine clinically relevant DDIs and HDIs leading to pharmaceutical intervention. Methods: Patients starting a new anticancer therapy were asked to complete a questionnaire to identify concomitant use of any over-the-counter drug or herbal supplement. Potential DDIs and HDIs were identified using two different databases. If a potentially clinically relevant DDI was recognized by the clinical pharmacist, a notification was sent to the prescribing oncologist, who decided whether to carry out a suggested intervention. Regression analyses were performed to identify variables associated with clinically relevant DDIs. Results: A total of 149 patients were included in this study, with 36 potentially clinically relevant DDIs identified in 26 patients (17.4%; 95% CI, 11.3% to 23.5%), all of them leading to therapy modifications. In total, four patients (2.7%; 95% CI, 0.1% to 5.3%) had experienced clinical consequences from DDIs at the time of pharmacist notification. Additionally, 84 patients (56.4%; 95% CI, 48.4% to 64.4%) reported using concurrent herbal supplements, and 122 possible HDIs were detected. Concomitant use of two or more drugs was independently associated with high risk of a clinically significant DDI (odds ratio, 2.53; 95% CI, 1.08 to 5.91; P = .03). Conclusion: Potentially clinically relevant DDIs and possible HDIs were frequently detected in this prospective study. A multidisciplinary approach is required to identify and avoid potentially harmful combinations with anticancer therapy.

scholarly journals Determination of Potential Drug–Drug Interactions Using Various Software Programs in a Community Pharmacy Setting

2019 ◽  
Vol 16 (1) ◽  
pp. 14-19
Author(s):  
Mesut SANCAR ◽  
Aksa KAŞIK ◽  
Betul OKUYAN ◽  
Sevda BATUHAN ◽  
Fikret Vehbi İZZETTİN
Keyword(s):  
Drug Interactions ◽  
Community Pharmacy ◽  
Potential Drug ◽  
Software Programs ◽  
Pharmacy Setting

scholarly journals A PROSPECTIVE STUDY OF DRUG–DRUG INTERACTIONS AND ADVERSE DRUG REACTIONS AMONG STROKE PATIENTS IN A TERTIARY CARE HOSPITAL

2016 ◽  
Vol 9 (9) ◽  
pp. 100
Author(s):  
Kavitha Samy P ◽  
Athira Jith ◽  
Chaithanya T Kumar ◽  
Joffey Sara Joy ◽  
Sambath Kumar R
Keyword(s):  
Prospective Study ◽  
Drug Interactions ◽  
Adverse Drug Reactions ◽  
Clinical Pharmacist ◽  
Prescription Data ◽  
Care Hospital ◽  
Care Providers ◽  
Drug Reactions ◽  
Stroke Patients ◽  
A Prospective Study

ABSTRACTObjective: Our study attempts to get an insight into the drug–drug interactions (DDIs) and adverse drug reactions (ADRs) among stroke patients fromthe Neurology Department in a private hospital.Methods: In a prospective study spanning 6 months (May to October 2015), we have analyzed the prescription data of 221 patients with bothischemic and hemorrhagic stroke. Gender, age, social habits, length of stay, drug utilization pattern, DDIs reported from the database and clinicallyobserved, and ADRs of individual drugs were observed among the patients. Of 221 cases, 208 (94.11%) were ischemic, 12 (5.43%) were hemorrhagic,and 1 (0.45%) was transient ischemic attack.Results: A number of 140 patients were males and 80 were females. The mean age of the patients was between 41 and 70 years. In ischemic patients,357 major, 282 moderate, and 38 mild DDIs were reported using a specific database, while in hemorrhagic patients, 10 major, 7 moderate, and 1 mildinteraction were reported using a specific database. 18 DDIs were observed clinically and confirmed with evidence. 8 DDI-induced ADRs and 10 ADRscaused by individual drugs were observed in our study population. 18 DDIs were observed clinically and confirmed with evidence. 8 DDI-inducedADRs and 10 ADRs caused by individual drugs were observed in our study population.Conclusion: Drugs if wrongly prescribed may cause negative outcomes and pose significant challenge to health-care providers and may contribute tomorbidity and mortality. Clinical pharmacist can play an important role in identifying and resolving drug-related problems through pharmaceuticalcare practices.Keywords: Stroke, Drug–drug interactions, Adverse drug reactions, Clinical pharmacist.

scholarly journals Statin drug-drug interactions in a Romanian community pharmacy

2016 ◽  
Vol 89 (2) ◽  
pp. 273-278 ◽  
Author(s):  
Raluca Badiu ◽  
Camelia Bucsa ◽  
Cristina Mogosan ◽  
Dan Dumitrascu
Keyword(s):  
Drug Interaction ◽  
Adverse Effects ◽  
Drug Interactions ◽  
Community Pharmacy ◽  
Safety Profile ◽  
Potential Drug ◽  
Online Program ◽  
High Prevalence ◽  
Statin Drug

Background and aim. Statins are frequently prescribed for patients with dyslipidemia and have a well-established safety profile. However, when associated with interacting dugs, the risk of adverse effects, especially muscular toxicity, is increased.The objective of this study was to identify, characterize and quantify the prevalence of the potential drug-drug interactions (pDDIs) of statins in reimbursed prescriptions from a community pharmacy in Bucharest.Methods. We analyzed the reimbursed prescriptions including statins collected during one month in a community pharmacy. The online program Medscape Drug Interaction Checker was used for checking the drug interactions and their classification based on severity: Serious – Use alternative, Significant – Monitor closely and Minor.Results. 132 prescriptions pertaining to 125 patients were included in the analysis. Our study showed that 25% of the patients who were prescribed statins were exposed to pDDIs: 37 Serious and Significant interactions in 31 of the statins prescriptions. The statins involved were atorvastatin, simvastatin and rosuvastatin.Conclusions. Statin pDDIs have a high prevalence and patients should be monitored closely in order to prevent the development of adverse effects that result from statin interactions.

Prevalence study on potential drug–drug interaction in cancer patients in Piacenza hospital’s Onco-Haematology department

2017 ◽  
Vol 24 (7) ◽  
pp. 490-493 ◽  
Author(s):  
Stefano Vecchia ◽  
Elena Orlandi ◽  
Corrado Confalonieri ◽  
Enrico Damonti ◽  
Alessandra Riva ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Supportive Care ◽  
Drug Interactions ◽  
Cancer Patients ◽  
Scientific Evidence ◽  
Chemotherapeutic Agents ◽  
Human Model ◽  
Potential Drug Interaction ◽  
Potential Drug ◽  
A Prospective Study

Background Cancer patients can be a human model of potential drug interactions. Usually they receive a large number of different medications, including antineoplastic agents, drugs for comorbid illness and medication for supportive care, however information about these interactions are fragmented and poor. Objective We assessed a prospective study to evaluate the prevalence of drug interaction among patients hospitalized in the Onco-Haematology department, Hospital of Piacenza. Methods Data on drugs administered for cancer, comorbidities, or supportive care were collected from different computerized prescription software in use in the department; we compared them with a database to focus on the co-administration of drugs. A literature review was performed to identify major potential drug interaction and to classify them by level of severity and by strengths of scientific evidence. Results In this study 284 cancer patients were enrolled; patients had taken an average of seven drugs on each day of therapy plus chemotherapeutic agents, we identified 67 potential drug interactions. At least 53 patients had one potential drug interaction. Of all potential drug interactions 63 were classified as moderate severity and only four as major. In 55 cases chemotherapeutic agents were involved in possible interactions with supportive care drugs, meanwhile in 12 cases the potential drug interactions were between supportive care drugs. Conclusions In our centre, thanks to a computerized prescription software, integrated with caution alarm in case of possible interaction, we had a lower rate of potential drug interactions than the one from literature. It is possible to improve the software integrating the alarm with the potential drug interactions between chemotherapy agents and supportive care drugs.

scholarly journals Drug-drug interactions in cancer patients: a prospective study of medication surveillance on cytotoxic agents

2016 ◽  
Vol 27 ◽  
pp. vi519
Author(s):  
A.E. Ramos-Esquivel ◽  
A. Viquez-Jaikel ◽  
C. Fernandez ◽  
Z. Zeledon ◽  
F. Jimenez ◽  
...  
Keyword(s):  
Prospective Study ◽  
Drug Interactions ◽  
Cancer Patients ◽  
Cytotoxic Agents ◽  
Medication Surveillance ◽  
A Prospective Study
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