scholarly journals Acute skin irritation, acute and sub-acute oral toxicity studies of Rosmarinus officinalis essential oils in mice and rabbit

2018 ◽  
Vol 12 (26) ◽  
pp. 389-396 ◽  
Author(s):  
Mengiste Berhan ◽  
Dires Kassahun ◽  
Lulekal Ermias ◽  
Arayaselassie Mahlet ◽  
Zenebe Tizazu ◽  
...  
Keyword(s):  
Essential Oils ◽  
Skin Irritation ◽  
Rosmarinus Officinalis ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies

scholarly journals Evaluation of acute oral toxicity study of essential oils (Eos) from Pogostemon benghalensis and P. cablin in Wistar rats

2020 ◽  
Vol 10 (3) ◽  
pp. 142-147
Author(s):  
DP Pradeep ◽  
K Murugan ◽  
G S Manoj
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Essential Oils ◽  
Organ Weight ◽  
Toxicity Study ◽  
Female Rats ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Male And Female ◽  
Toxicity Studies

The use of crude herbal decoctions in the traditional treatment of diseases is a common practice.  Pogostemon benghalensis and P. cablin are commonly used for treatment of diverse categories of diseases such as infectious and non-infectious disease. Native people use the crude decoctions as bactericidal, antimalarial, anti-leshimania, anti-diarrheal and insecticidal activities. Its safety profile is not yet elucidated and therefore, this study was to analyze the acute toxicity of essential oils (Eos) from P. benghalensis and P. cablin as medicinal. Methods include acute toxicity study using male and female Wistar albino rats with single oral dose and followed up to 14 days as per the guidelines of OECD. Visual observations were carried regularly during the experimental period while body weight was measured weekly. Organ weight, clinical chemistry and hematology data were collected on the 7th and 14th days. Results were presented as mean ± standard deviation. One-way analysis of variance (ANOVA) was carried. Oral administration of Eos from P. benghalensis and P. cablin revealed no treatment-related mortality in female rats up to the dose of 5000 mg/kg. In acute toxicity studies, no remarkable treatment related anomalies were observed compared to negative controls. Food consumption, body weight, organ weight, hematology did not showed sound variation between controls and treatment groups. However, creatinine, triglycerides, and monocytes were lower in the treated groups in 7th day as compared to control groups. No significant variations between male and female groups in relative organ weight, hematology were noticed. In conclusion, the Eos from P. benghalensis and P. cablin showed LD50 > 3000 mg/kg in acute toxicity studies. Keywords: Pogostemon benghalensis, P. cablin, traditional medicine, safety, plant medicine, adverse effect, acute oral toxicity

scholarly journals SYNTHESIS AND CHARACTERIZATION OF A NOVEL MUCOADHESIVE DERIVATIVE OF PSYLLIUM SEED POLYSACCHARIDE

2017 ◽  
Vol 9 (6) ◽  
pp. 166
Author(s):  
Monica R.p. Rao ◽  
Snehal R. Gaikwad ◽  
Prachi M. Shevate
Keyword(s):  
Retention Time ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Drug Release Profile ◽  
Toxicity Studies ◽  
Percent Increase ◽  
Human Use ◽  
Ellman’S Method ◽  
Thiol Functionalization

Objective: In the present study, thiol-functionalization of psyllium seed polysaccharide (PSY) was cross-linked with thioglycolic acid by esterification in an attempt to reveal the mucoadhesive properties of thiolated psyllium seed polysaccharide (TPSY).Methods: The crosslinking was carried out by the microwave-assisted method. A simplex centroid design was employed to systematically study the mucoadhesive strength, mucoadhesive retention time and drug release profile. Comparative evaluation of carbopol-based ciprofloxacin hydrochloride (HCl) tablets containing PSY and TPSY was carried out. Acute oral toxicity studies and repeated oral toxicity for TPSY were also conducted.Results: Thiol-functionalization was confirmed by-SH stretch in Fourier Transform infra-red spectra at 2353 cm-1. Thiolation was observed in thiolated PSY (TPSY) by a change in the surface morphology of psyllium from fibrous to granular and resulted in 82 %swelling in deionized water. TPSY was found to contain 102.35 mmol of thiol groups/g as determined by the Ellman’s method. The percent increase in mucoadhesive strength of TPSY was found to be 50.31 % as compared to PSY and 128.30 % as compared to carbopol. The percent increase in mucoadhesive retention time of TPSY was found to be 110 % as compared to PSY and 50 % as compared to carbopol.Conclusion: Mucoadhesion strength and mucoadhesive retention time were greater of tablets containing a higher amount of TPSY. Further, the acute oral toxicity studies and repeated oral toxicity for TPSY proved it as non-toxic and hence safe for human use.

Acute and sub-acute oral toxicity studies of standardized extract of Nasturtium officinale in Wistar rats

2019 ◽  
Vol 108 ◽  
pp. 104443 ◽  
Author(s):  
M. Clemente ◽  
M.D. Miguel ◽  
K.B. Felipe ◽  
C. Gribner ◽  
P.F. Moura ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Nasturtium Officinale ◽  
Toxicity Studies

Acute oral toxicity and repeated dose 28-day oral toxicity studies of MIL-101 nanoparticles

2019 ◽  
Vol 107 ◽  
pp. 104426 ◽  
Author(s):  
Chia-Hung Liu ◽  
Hsien-Chun Chiu ◽  
Hsiang-Ling Sung ◽  
Jyun-Yi Yeh ◽  
Kevin C.-W. Wu ◽  
...  
Keyword(s):  
Repeated Dose ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies

Evaluation and solubility improvement of Carvedilol: PSC[n]arene inclusion complexes with acute oral toxicity studies

2011 ◽  
Vol 73 (1-4) ◽  
pp. 295-303 ◽  
Author(s):  
Shobhana K. Menon ◽  
Bhoomika R. Mistry ◽  
Kuldeep V. Joshi ◽  
Nishith R. Modi ◽  
Divyesh Shashtri
Keyword(s):  
Inclusion Complexes ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Solubility Improvement

scholarly journals Antitumor Effects and Acute Oral Toxicity Studies of a Plant Extract Mixture Containing <i>Rhus verniciflua</i> and Some Other Herbs

2015 ◽  
Vol 05 (01) ◽  
pp. 39-49 ◽  
Author(s):  
Wataru Hiruma ◽  
Kohei Suruga ◽  
Kazunari Kadokura ◽  
Tsuyoshi Tomita ◽  
Ayaka Miyata ◽  
...  
Keyword(s):  
Plant Extract ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Antitumor Effects ◽  
Toxicity Studies ◽  
Rhus Verniciflua
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