scholarly journals Comparative pharmacokinetic study of luteolin after oral administration of Chinese herb compound prescription JiMaiTong in spontaneous hypertensive rats (SHR) and Sprague Dawley (SD) rats

2014 ◽  
Vol 8 (16) ◽  
pp. 422-428
Author(s):  
Lou Zhao-Huan ◽  
Chen Su-Hong ◽  
Lv Gui-Yuan ◽  
Xia Bo-Hou ◽  
Yan Mei-Qiu ◽  
...  
Keyword(s):  
Oral Administration ◽  
Pharmacokinetic Study ◽  
Chinese Herb ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Comparative Pharmacokinetic ◽  
Sd Rats

scholarly journals Comparative Pharmacokinetic Study of Mangiferin After Oral Administration of Pure Mangiferin and US Patented Polyherbal Formulation to Rats

2014 ◽  
Vol 16 (2) ◽  
pp. 250-258 ◽  
Author(s):  
Ananth Kumar Kammalla ◽  
Mohan Kumar Ramasamy ◽  
Jyothi Inampudi ◽  
Govind Prasad Dubey ◽  
Aruna Agrawal ◽  
...  
Keyword(s):  
Oral Administration ◽  
Pharmacokinetic Study ◽  
Comparative Pharmacokinetic ◽  
Polyherbal Formulation

scholarly journals Effect of a methionine-supplemented diet on the blood pressure of Sprague–Dawley and deoxycorticosterone acetate–salt hypertensive rats

2004 ◽  
Vol 91 (6) ◽  
pp. 857-865 ◽  
Author(s):  
Sophie Robin ◽  
Véronique Maupoil ◽  
Pascal Laurant ◽  
Alain Jacqueson ◽  
Alain Berthelot
Keyword(s):  
Blood Pressure ◽  
Positive Association ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Aortic Constriction ◽  
Deoxycorticosterone Acetate ◽  
Complex Interactions ◽  
Sd Rats ◽  
Salt Hypertension ◽  
Methionine Supplementation

The objectives of the present study were to evaluate the effects of a methionine-supplemented diet on systolic blood pressure (BP) and vasomotor functions in Sprague–Dawley (SD) and deoxycorticosterone acetate (DOCA)–salt hypertensive rats. SD and DOCA rats were fed a normal or a methionine (8 g/kg)-supplemented diet for 10 weeks. Systolic BP was monitored and plasma homocysteine, methionine and cysteine levels were determined at the end of the experiment. Vasoconstriction and vasodilatation of aortic rings were measured. The methionine-supplemented diet induced a greater increase in homocysteinaemia concentration in DOCA rats than in SD rats and an increase in plasma cysteine concentration in DOCA rats. This diet was associated with an increase in systolic BP in SD rats and with a lesser development of DOCA–salt hypertension. An enhanced aortic constriction and a decreased responsiveness to acetylcholine, bradykinin and sodium nitroprusside in the SD rats fed the methionine-rich diet were consistent with the elevated systolic BP. In DOCA rats the increased responsiveness to bradykinin was in accordance with the systolic BP-lowering effect. In conclusion, the methionine-enriched diet cannot simply be considered as model of hyperhomocysteinaemia, since other metabolites and mechanisms seemed to be implicated in these complex interactions. The differential vasopressive effect of the methionine supplementation in SD and DOCA rats, and in particular the lowering of systolic BP obtained with a greater degree of hyperhomocysteinaemia in DOCA rats, suggest that more complex interactions exist between hyperhomocysteinaemia and BP than the simple positive association described previously.

Overflow of endogenous norepinephrine from PVH nucleus of DOCA-salt hypertensive rats

1995 ◽  
Vol 268 (4) ◽  
pp. H1549-H1554 ◽  
Author(s):  
J. M. Qualy ◽  
T. C. Westfall
Keyword(s):  
Sodium Nitroprusside ◽  
Genetic Model ◽  
Spontaneously Hypertensive Rat ◽  
Tap Water ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Sd Rats ◽  
Salt Hypertension ◽  
Wistar Kyoto

Previous studies from this laboratory demonstrated that there was enhanced basal and evoked (K+ depolarization) overflow of endogenous norepinephrine (NE) into the perfusate of a push-pull cannula placed in the paraventricular nucleus of the hypothalamus (PVH) of conscious freely moving spontaneously hypertensive rat (SHR) compared with Wistar-Kyoto (WKY) or Sprague-Dawley (SD) rats. The present study was carried out to determine whether results obtained with SHR were specific to this genetic model of hypertension by examining NE release in deoxycorticosterone acetate (DOCA)-salt hypertension. DOCA-salt hypertension was produced in 8-wk-old uninephrectomized SD rats by administering a 50-mg DOCA Silastic pellet subcutaneously 7 days postnephrectomy and providing 0.9% NaCl + 0.2% KCl drinking solution at libitum for 3 wk. Sham-implanted animals received normal tap water. Blood pressure was similar to that of 8- to 10-wk-old SHR. Basal release of NE as well as release after K+ added to the push-pull cannula or sodium nitroprusside or phenylphrine administered intravenously was determined. It was observed that there was no difference in basal overflow or after K+ administration in DOCA-salt hypertensive rats compared with sham animals. Similarly, the increase in NE overflow due to sodium nitroprusside or the decrease due to phenylphrine was similar between DOCA-salt rats or sham controls. This was in sharp contrast to what was observed in SHR: basal or K(+)-evoked release was significantly greater in SHR than WKY, SD, DOCA-salt, or DOCA-sham controls. It is concluded that central noradrenergic activity involving the PVH is not altered in DOCA-salt hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)

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