scholarly journals Homocysteine, not high-sensitivity C-reactive protein, associates with the intima-media thickness of carotid artery and arterial stiffness

2013 ◽  
Vol 7 (9) ◽  
pp. 503-511
Author(s):  
Dongmei Miao
Keyword(s):  
Carotid Artery ◽  
Arterial Stiffness ◽  
High Sensitivity ◽  
Intima Media Thickness ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Media Thickness

Association of high-sensitivity C-reactive protein with carotid artery intima-media thickness in hypertensive older adults

2011 ◽  
Vol 5 (5) ◽  
pp. 395-400 ◽  
Author(s):  
Moatassem S. Amer ◽  
Amal E. Elawam ◽  
Mohamed S. Khater ◽  
Omar H. Omar ◽  
Randa A. Mabrouk ◽  
...  
Keyword(s):  
Older Adults ◽  
Carotid Artery ◽  
High Sensitivity ◽  
Intima Media Thickness ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Media Thickness

scholarly journals High-Sensitivity C-Reactive Protein and Carotid Intima Media Thickness as Markers of Subclinical Inflammation and Atherosclerosis in Pediatric Patients with Hypercholesterolemia

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5118
Author(s):  
Lana Blinc ◽  
Matej Mlinaric ◽  
Tadej Battelino ◽  
Urh Groselj
Keyword(s):  
Subclinical Atherosclerosis ◽  
Elevated Serum ◽  
High Sensitivity ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Low Grade ◽  
C Reactive Protein ◽  
Atherosclerosis Progression ◽  
Reactive Protein ◽  
Media Thickness

Hypercholesterolemia is a major cause of atherosclerosis development and premature cardiovascular disease (CVD). It leads to inflammation, which further accelerates atherosclerosis progression. Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by elevated serum LDL-c from birth, due to a disease-causing variant in one of the causative genes (LDLR, APOB, PCSK9). In polygenic hypercholesterolemia (PH), the disease-causing genetic variant is absent; it is likely the cumulative result of multiple single nucleotide polymorphisms in LDL metabolism-related genes and other factors, such as lifestyle and environment. In high risk groups, such as patients with FH, an effective primary prevention of CVD must begin in childhood. High-sensitivity C-reactive protein (hsCRP) and carotid intima media thickness (cIMT) are two potential minimally invasive correlates of inflammation and subclinical atherosclerosis progression. hsCRP and cIMT have been shown to be significantly increased in patients with FH and PH relative to healthy controls, with some studies yielding conflicting results. In this review, we aim to summarize current knowledge and recent findings regarding the applicability of hsCRP and cIMT as markers of low-grade inflammation and subclinical atherosclerosis, focusing especially on children and adolescents with hypercholesterolemia.

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