Significance of the distribution of platelet-derived growth factor B chain in arteriosclerosis plaque in type-2 diabetic patients with arteriosclerosis obliterans of lower extremity

2012 ◽  
Vol 6 (29) ◽  
Author(s):  
Xu Li
Keyword(s):  
Growth Factor ◽  
Lower Extremity ◽  
Platelet Derived Growth Factor ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Factor B ◽  
Arteriosclerosis Obliterans ◽  
Type 2 Diabetic

Inverse Association of Serum Fibroblast Growth Factor 19 and Atherogenic Index of Plasma in Type 2 Diabetic Patients

2020 ◽  
Author(s):  
Wangshu Liu ◽  
Tianli Xu ◽  
Mengjie Tang ◽  
Xue-Qin Wang ◽  
Jianbin Su ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Atherogenic Index ◽  
Diabetic Patients ◽  
Fibroblast Growth ◽  
Type 2 Diabetic Patients ◽  
Atherogenic Index Of Plasma ◽  
Fibroblast Growth Factor 19 ◽  
Type 2 Diabetic

Abstract BackgroundWe aimed to explore the relationship between serum fibroblast growth factor 19 (FGF19) and the atherogenic index of plasma (AIP) in type 2 diabetic patients.MethodsSerum FGF19 levels and lipid profiles were measured in 200 patients with type 2 diabetes (T2D). The levels of serum FGF19 were measured by ELISA. Lipid profiles were measured by enzymatic analysis. AIP and NAFLD fibrosis scores were calculated.ResultsT2D patients showed a significant decreasing trend of FGF19 concentrations depending on the tertiles of AIP (p for trend < 0.05). Simultaneously, the AIP level was closely related to the serum FGF19 level (p < 0.05). Furthermore, after adjusting for age, sex, duration, BMI, hypertension, and diabetic treatment, the correlation was still significant (p < 0.01), and it remained significant even after further adjusting for non-alcoholic fatty liver disease (NAFLD) and NAFLD fibrosis score (NFS) (p < 0.01). However, when stratified by BMI, AIP was positively correlated with FGF19 in normal-weight and overweight T2D patients but not in obese T2D subjects. After adjusting for sex, age, BMI, duration, hypertension, HbA1c, 2hPG, HOMA-IR, AIP, antidiabetic treatments, NAFLD and NFS via multiple stepwise linear regression, AIP was an independent factor affecting serum FGF19 concentrations (SE = 0.238, β = -0.290, p < 0.01).ConclusionsSerum FGF19 levels might be a good predictor for atherosclerosis and cardiovascular disease in T2D patients, especially among non-obese patients; serum FGF19 levels were significantly inversely associated with AIP.

A study of the relation between insulin resistance, insulin-like growth factor-1, and malignancy in type 2 diabetic patients

2015 ◽  
Vol 28 (2) ◽  
pp. 494
Author(s):  
DoaaS Elgendy ◽  
NabilA El Kafrawy ◽  
AliZ Glal ◽  
MonaA Kandil ◽  
AlaaA Eldin Dawood ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Growth Factor ◽  
Diabetic Patients ◽  
Insulin Like Growth Factor ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Frequency of lower extremity artery disease in type 2 diabetic patients using pulse oximetry and the ankle-brachial index

2021 ◽  
Vol 18 (13) ◽  
pp. 2776-2782
Author(s):  
Mosquera-Fernández Abián ◽  
Balboa-Barreiro Vanesa ◽  
Bellido-Guerrero Diego ◽  
González-Sagrado Manuel ◽  
Vale-Carrodeguas Maria ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Pulse Oximetry ◽  
Ankle Brachial Index ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Artery Disease ◽  
Lower Extremity Artery Disease ◽  
Type 2 Diabetic

Electrophysiological Abnormalities in Type 2 Diabetic Patients with Reduced Levels of Insulin-like Growth Factor I

2006 ◽  
Vol 34 (1) ◽  
pp. 21-29 ◽  
Author(s):  
R Godínez-Gómez ◽  
B Trujillo-Hernández ◽  
CE Tene ◽  
M Huerta ◽  
X Trujillo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Diabetic Patients ◽  
Insulin Like Growth Factor ◽  
Type 2 Diabetic Patients ◽  
Factor I ◽  
Growth Factor I ◽  
Type 2 Diabetic
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