scholarly journals Influence of naringin on the myocardial ultrastructure and NF-B expression in rats with diabetic cardiomyopathy

2013 ◽  
Vol 7 (8) ◽  
pp. 439-443 ◽  
Author(s):  
Keng Wu
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Myocardial Ultrastructure

167-OR: Activation of Myocardial Mitochondria Akt1 Improved Diabetic Cardiomyopathy and Body Composition—The Heart as a Metabolic Organ

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 167-OR
Author(s):  
YU-HAN CHEN ◽  
ALBERT TA ◽  
HSIAOCHEN LEE ◽  
HUGO YOU-HSIEN LIN ◽  
YUMAY CHEN ◽  
...  
Keyword(s):  
Body Composition ◽  
Diabetic Cardiomyopathy ◽  
Myocardial Mitochondria

Novel "Dual Hit" Rat Model of Diabetic Cardiomyopathy

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 466-P ◽  
Author(s):  
LOUISE THISTED ◽  
ROSS T. LINDSAY ◽  
KELD FOSGERAU ◽  
THOMAS SECHER ◽  
MORTEN B. THOMSEN ◽  
...  
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Rat Model

186-OR: Safety and Tolerability of the Next Generation Aldose Reductase Inhibitor (ARI) AT-001 Supports Initiation of the Pivotal Trial in Diabetic Cardiomyopathy (DbCM)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 186-OR
Author(s):  
RICCARDO PERFETTI ◽  
FRANCESCA C. LAWSON ◽  
JULIO ROSENSTOCK ◽  
JAMES JANUZZI ◽  
SHOSHANA SHENDELMAN ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Diabetic Cardiomyopathy ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Pivotal Trial ◽  
Next Generation

Beneficial effects of verapamil in diabetic cardiomyopathy

Diabetes ◽  
1988 ◽  
Vol 37 (7) ◽  
pp. 936-942 ◽  
Author(s):  
N. Afzal ◽  
P. K. Ganguly ◽  
K. S. Dhalla ◽  
G. N. Pierce ◽  
P. K. Singal ◽  
...  
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Beneficial Effects

Diabetic Cardiomyopathy: From Mechanism to Management in a Nutshell

2020 ◽  
Vol 20 ◽  
Author(s):  
Shahzad Khan ◽  
Syed S. Ahmad ◽  
Mohammad A. Kamal
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Immune Modulation ◽  
Cell Injury ◽  
Interstitial Fibrosis ◽  
Systolic Dysfunction ◽  
Therapeutic Strategies ◽  
Cardiac Cell ◽  
Clinical Heart Failure ◽  
Artery Disease ◽  
Apoptosis And Necrosis

: Diabetic cardiomyopathy (DCM) is a significant complication of diabetes mellitus characterized by gradual failing heart with detrimental cardiac remodellings such as fibrosis and diastolic and systolic dysfunction, which is not directly attributable to coronary artery disease. Insulin resistance and resulting hyperglycemia is the main trigger involved in the initiation of diabetic cardiomyopathy. There is a constellation of many pathophysiological events such as lipotoxicity, oxidative stress, inflammation, inappropriate activation of the renin-angiotensin-aldosterone system, dysfunctional immune modulation promoting increased rate of cardiac cell injury, apoptosis, and necrosis which ultimately culminates into interstitial fibrosis, cardiac stiffness, diastolic dysfunction initially and later systolic dysfunction too. These events finally lead to clinical heart failure of DCM. Herein, we have briefly discussed the pathophysiology of DCM. We have also briefly mentioned potential therapeutic strategies currently used for DCM.

Sign in / Sign up

Export Citation Format

Share Document