scholarly journals Potential drug targets prediction for H1N1 influenza A based on protein-protein interaction networks

2012 ◽  
Vol 6 (42) ◽  
pp. 2950-2955
Author(s):  
Di Chen#
Keyword(s):  
Protein Interaction ◽  
Drug Targets ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Protein Interaction Networks ◽  
Interaction Networks ◽  
Potential Drug ◽  
Protein Protein Interaction ◽  
Protein Protein Interaction Networks ◽  
Potential Drug Targets

scholarly journals Deubiquitinases and the new therapeutic opportunities offered to cancer

2015 ◽  
Vol 22 (1) ◽  
pp. T35-T54 ◽  
Author(s):  
Roland Pfoh ◽  
Ira Kay Lacdao ◽  
Vivian Saridakis
Keyword(s):  
Thyroid Cancer ◽  
Protein Interaction ◽  
Adrenocortical Carcinoma ◽  
Drug Targets ◽  
Protein Interaction Networks ◽  
Interaction Networks ◽  
Regulatory Mechanisms ◽  
Potential Drug ◽  
Diagnosis And Prognosis ◽  
Potential Drug Targets

Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in various diseases including cancer and neurodegeneration. In this review, we recapitulate structure–function studies of the most studied DUBs including USP7, USP22, CYLD, UCHL1, BAP1, A20, as well as ataxin 3 and connect them to regulatory mechanisms and their growing protein interaction networks. We then describe DUBs that have been associated with endocrine carcinogenesis with a focus on prostate, ovarian, and thyroid cancer, pheochromocytoma, and adrenocortical carcinoma. The goal is enhancing our understanding of the connection between dysregulated DUBs and cancer to permit the design of therapeutics and to establish biomarkers that could be used in diagnosis and prognosis.

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