scholarly journals Investigation of microemulsion system for transdermal delivery of ligustrazine phosphate

2011 ◽  
Vol 5 (14) ◽  
pp. 1674-1681 ◽  
Author(s):  
Ying Cui
Keyword(s):  
Transdermal Delivery ◽  
Microemulsion System ◽  
Ligustrazine Phosphate

Investigation of microemulsion system for transdermal delivery of meloxicam

2006 ◽  
Vol 321 (1-2) ◽  
pp. 117-123 ◽  
Author(s):  
Yue Yuan ◽  
San-ming Li ◽  
Feng-kui Mo ◽  
Da-fang Zhong
Keyword(s):  
Transdermal Delivery ◽  
Microemulsion System

scholarly journals Investigation of microemulsion system for transdermal delivery of itraconazole

2011 ◽  
Vol 2 (1) ◽  
pp. 30 ◽  
Author(s):  
Chamanlal Shishoo ◽  
Arpan Chudasama ◽  
Vineetkumar Patel ◽  
Manish Nivsarkar ◽  
Kamala Vasu
Keyword(s):  
Transdermal Delivery ◽  
Microemulsion System

Third-Generation Transdermal Delivery Systems Containing Zidovudine: Effect of the Combination of Different Chemical Enhancers and a Microemulsion System

2018 ◽  
Vol 19 (7) ◽  
pp. 3219-3227 ◽  
Author(s):  
André Luis Menezes Carvalho ◽  
José Alexsandro Silva ◽  
Ana Amélia Moreira Lira ◽  
Ellen Denise Prado Almeida ◽  
Rogéria de Souza Nunes ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Delivery Systems ◽  
Microemulsion System ◽  
Third Generation ◽  
Chemical Enhancers

scholarly journals Influence of microemulsion components on transdermal delivery of immunomodulator glucosaminylmuramyl dipeptide

2020 ◽  
Vol 22 (3) ◽  
pp. 149-155
Author(s):  
E. G. Kuznetsova ◽  
O. M. Kuryleva ◽  
L. A. Salomatina ◽  
S. V. Kursakov ◽  
S. V. Guryanova ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
High Performance ◽  
Raw Materials ◽  
Sodium Dodecyl ◽  
Reversed Phase ◽  
Tocopheryl Acetate ◽  
Microemulsion System ◽  
Rabbit Skin ◽  
Docusate Sodium

This paper demonstrates a chemical way of enhancing transdermal delivery using immunomodulator glucosaminylmuramyl dipeptide (GMDP) as an example. Objective: to study in vitro the effect of various components of the microemulsion composition on GMDP diffusion through the skin from a transdermal therapeutic system (TTS). Materials and methods. Medicinal substance – glucosaminylmuramyl dipeptide (Peptek, Russia). Excipients and raw materials: sodium chloride, purified water, sodium dodecyl sulfate, docusate sodium, oak bark, apricot kernel oil, alpha-tocopheryl acetate and Decaglyn PR-20 emulsifier. Equipment: Heidolph DIAX 900 mechanical disperser (Germany) and Hielscher UIS250V ultrasonic homogenizer (Germany). GMDP diffusion from TTS through unpreserved rabbit skin was studied on diffusion tester Copley (UK). GMDP in aqueous solutions was determined by reversed-phase high-performance liquid chromatography (RP-HPLC) on an Agilent 1200 chromatography system (Agilent Technologies, USA). Results. A microemulsion system composed of 20% docusate sodium in an oil phase and an oak bark decoction as an aqueous phase was developed. This made it possible to increase GMDP transdermal delivery by ~70% in comparison with the basic composition. Conclusion. The characteristic parameters of microemulsion components of GMDP contained in TTS, influencing GMDP diffusion through unpreserved rabbit skin in vitro, were determined. Introducing relative indicators would be advisable in order to correctly evaluate the results of different series of in vitro experiments with biological objects.

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