scholarly journals Utility of molecular diagnostic method compared with conventional methods in detection of etiologic agents of central nervous system infections in Rwanda

2019 ◽  
Vol 13 (9) ◽  
pp. 176-187
Author(s):  
Ntagwabira Edouard ◽  
Wanjiru Mureithi Marianne ◽  
Baptiste Mazarati Jean ◽  
Jaoko Walter ◽  
Anzala Omu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Diagnostic Method ◽  
Molecular Diagnostic ◽  
Central Nervous System Infections ◽  
Etiologic Agents ◽  
Conventional Methods ◽  
Molecular Diagnostic Method

Etiologic agents of central nervous system infections in Georgia

2013 ◽  
Vol 333 ◽  
pp. e665-e666
Author(s):  
T. Akhvlediani ◽  
E. Rowlinson ◽  
C. Bautista ◽  
M. Farrell ◽  
T. Kuchuloria ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Infections ◽  
Etiologic Agents

scholarly journals Metagenomic Next-generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Central Nervous System infections in HIV-infected patients

2019 ◽  
Author(s):  
Nai qing Zheng ◽  
Pengle Guo ◽  
Xiejie Chen ◽  
Haolan He ◽  
Yueping Li ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Next Generation Sequencing ◽  
Clinical Diagnosis ◽  
Central Nervous System Infection ◽  
Next Generation ◽  
Central Nervous System Infections ◽  
Cns Infections ◽  
Conventional Methods ◽  
Generation Sequencing

Abstract Background HIV-infected patients have extremely low immunity and various opportunistic infections. Early diagnosis and treatment of these pathogens is critical for patients with HIV infection, especially those with central nervous system (CNS) infections. Metagenomic next generation sequencing (mNGS) has the advantage of identifying a broad range of pathogens and was suggested as a promising tool in the clinical diagnosis for infectious diseases. The clinical application of mNGS in the diagnosis of CNS infections in patients infected with HIV remains inadequately characterized.Methods We retrospectively analyzed data from 22 patients with suspected central nervous system infections who underwent both mNGS and conventional methods including culture, PCR, X-pert/RIF and antigen testing to explored the utility of mNGS in clinical diagnostic microbiology of CNS infections in HIV-infected patients.Results A total of 22 patients participated in the study between June 2018 and May 2019. The consistency of positive percentage of mNGS compared to clinical diagnosis was significantly higher than that of conventional methods (86.36% vs. 45.21%). The proportion of co-infections in mNGS positive samples was significantly higher than that in traditional methods (40.91% vs. 14.39%). Sixteen Extra Pathogens in 14 cases identified by metagenomic NGS only, 6 pathogens affected clinical reasoning and 7 pathogens guided antimicrobial therapy.Conclusions MNGS is a powerful diagnostic method for identifying pathogens in central nervous system infections and provide actionable information in some cases. MNGS technology has positive significance for the diagnosis and clinical treatment of central nervous system infection in HIV-infected patients.

scholarly journals Etiologic Agents of Central Nervous System Infections among Febrile Hospitalized Patients in the Country of Georgia

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e111393 ◽  
Author(s):  
Tamar Akhvlediani ◽  
Christian T. Bautista ◽  
Roman Shakarishvili ◽  
Tengiz Tsertsvadze ◽  
Paata Imnadze ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hospitalized Patients ◽  
Central Nervous System Infections ◽  
Etiologic Agents ◽  
Country Of Georgia

Management of central nervous system infections during an epidemic of enteroviral aseptic meningitis

1980 ◽  
Vol 96 (3) ◽  
pp. 559-563 ◽  
Author(s):  
Jonathan I. Singer ◽  
Philip R. Maur ◽  
John P. Riley ◽  
Pamela Burger Smith
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Aseptic Meningitis ◽  
Central Nervous System Infections

Diffusion imaging in pediatric central nervous system infections

2001 ◽  
Vol 43 (12) ◽  
pp. 1031-1039 ◽  
Author(s):  
J. Teixeira ◽  
R. Zimmerman ◽  
J. Haselgrove ◽  
L. Bilaniuk ◽  
J. Hunter
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Diffusion Imaging ◽  
Central Nervous System Infections
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