scholarly journals Incidence of bacterial infection in chronic hepatitis C virus (HCV) patients with cirrhosis and association between toll-like receptor 4 D299G gene polymorphism and Gram- negative bacterial infections in the patients

2018 ◽  
Vol 12 (13) ◽  
pp. 307-311
Author(s):  
El-Bassat Hanan ◽  
Abo Ali Lobna ◽  
Taha Atef ◽  
Alm El-Din Rasha
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Gene Polymorphism ◽  
Bacterial Infection ◽  
Bacterial Infections ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Gram Negative ◽  
Chronic Hepatitis C Virus

scholarly journals Cytokine (IL-10, IL-6, TNF-α and TGF-β1) Gene Polymorphisms in Chronic Hepatitis C Virus Infection among Malay Male Drug Abusers

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1115
Author(s):  
Ismail Che Noh ◽  
Imran Ahmad ◽  
Siti Suraiya ◽  
Nur Fadhlina Musa ◽  
Asma Abdullah Nurul ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Gene Polymorphism ◽  
Drug Abusers ◽  
Hepatitis C Virus Infection ◽  
Tnf Α ◽  
Chronic Hepatitis C Virus ◽  
Tgf Β1

Cytokines play an important role in modulating inflammation during viral infection, including hepatitis C virus (HCV) infection. Genetic polymorphisms of cytokines can alter the immune response against this infection. The objective of this study was to investigate the possible association between chronic hepatitis C virus infection susceptibility and cytokine gene polymorphism for interleukin-10 (IL-10) rs1800896 and rs1800871, interleukin 6 (IL-6) rs1800795, TNF-α rs1800629, and TGF-β1 rs1800471 in Malay male drug abusers. The study was conducted on 76 HCV-positive (HP) male drug abusers and 40 controls (HCV-negative male drug abusers). We found that there were significant differences in the frequencies of genotype for IL-10 rs1800871 (p = 0.0386) and at the allelic level for IL-10 rs1800896 A versus G allele (p = 0.0142) between the HP group and the control group. However, there were no significant differences in gene polymorphism in interleukin 6 rs1800795, TNF-α rs1800629 and TGF-β1 rs1800471. These findings suggest significant associations between gene polymorphism for IL-10 rs1800871, IL-10 rs1800896 (at the allelic level) and susceptibility to HCV infection among Malay male drug abusers.

scholarly journals Chemokine receptor CXCR6 gene polymorphism and treatment response of chronic hepatitis C virus in Egyptian patients

2021 ◽  
Vol 7 (4) ◽  
pp. 370-376
Author(s):  
Mona M Hassona ◽  
Tamer Fouad ◽  
Merhan Osama Helmi ◽  
Heba Samy Mohammed Ghanem ◽  
Heba E Abd Elrhman ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Gene Polymorphism ◽  
Treatment Response ◽  
Chronic Hepatitis C ◽  
Chemokine Receptor ◽  
Egyptian Patients ◽  
Chronic Hepatitis C Virus
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