scholarly journals Extended-spectrum beta-lactamase- and carbapenemase-producing Enterobacteriaceae clinical isolates in a Senegalese teaching hospital: A cross sectional study

2017 ◽  
Vol 11 (44) ◽  
pp. 1600-1605 ◽  
Author(s):  
Camara Makhtar ◽  
Thierry Mane Mamadou ◽  
Ba-Diallo Awa ◽  
Dieng Assane ◽  
Diop-Ndiaye Halimatou ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
Cross Sectional Study ◽  
Clinical Isolates ◽  
Beta Lactamase ◽  
Sectional Study ◽  
Cross Sectional ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum

scholarly journals Predicting carriage with extended-spectrum beta-lactamase-producing bacteria at hospital admission: a cross-sectional study

2015 ◽  
Vol 21 (2) ◽  
pp. 141-146 ◽  
Author(s):  
T.N. Platteel ◽  
M.A. Leverstein-van Hall ◽  
J.W. Cohen Stuart ◽  
S.F.T. Thijsen ◽  
E.M. Mascini ◽  
...  
Keyword(s):  
Hospital Admission ◽  
Cross Sectional Study ◽  
Beta Lactamase ◽  
Sectional Study ◽  
Cross Sectional ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum

scholarly journals Isolation of extended spectrum beta-lactamase producing Enterobacteriaceae among children with urinary tract infection: A cross sectional study.

2020 ◽  
Author(s):  
asnakech agegnehu ◽  
Mesfin Worku ◽  
Demiss Nigussie ◽  
Birkneh Tilahun Tadesse ◽  
Birhanu Lulu
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Cross Sectional Study ◽  
Beta Lactamase ◽  
Sectional Study ◽  
Cross Sectional ◽  
Extended Spectrum Beta Lactamase ◽  
E Coli ◽  
Extended Spectrum ◽  
Resistant Strains

Abstract Background: Resistance of Gram-negative bacteria to antibiotics had increased at an alarming pace over the last two decades. Empirical antibiotic treatment of UTI practice created opportunity for frequent use of antibiotics that resulted in emergence of resistant strains. Extended spectrum beta-lactamase producing Enterobacteriaceae are emerging worldwide and are usually multi-drug resistant; thus, limiting treatment options for these organisms. Hence, it is mandatory to scrutinize the extent of the problem in the study area. Objective: We investigated the prevalence and correlates of extended spectrum beta-lactamase producing Enterobacteriaceae and their antibacterial resistance profile among children with urinary tract infection (UTI) at Hawassa University Comprehensive Specialized Hospital. Method: A hospital-based cross sectional study was conducted from February 1-July 30/ 2018. A semi-structured questionnaire was used to collect data from 284 children suspected of UTI. Bacterial species were isolated using standard bacteriological techniques. Antibiotic susceptibility testing was done using Kirby-Bauer disk diffusion method and ESBL production was detected by double disc synergy test. Data entry, cleaning and statistical analysis was done using SPSS version 20. Results: Overall, Enterobacteriaceae accounted for 75% (72/96) of UTI infections. The most frequent Enterobacteriaceae were E. coli , 44.4% (32/72) and K. pneumoniae , 27.8% (20/72). Overall, ESBL-producers within Enterobacteriaceae accounted for 41.7% (30/72) and magnitude of multi-drug resistance level was 86.1% (62/72). ESBL producing K. pneumoniae and E. coli accounted for 70% (14/20) and 37.5% (12/32), respectively of all the respective isolates. Previous UTI within the past 12 month (AOR= 0.08, 95% CI (0.01-0.57) and medium family wealth index (AOR = 0.03, 95% CI (0.00-0.27) were associated with infection of ESBL-producing Enterobacteriaceae . Conclusion: ESBL producing Enterobacteriaceae were prevalent among UTI cases; where E. coli and K. pneumoniae were the major isolated resistant strains that contributed mainly to the problem. Majority of Enterobacteriaceae isolated were resistant to commonly prescribed drugs. Key words : ESBL, Antimicrobial Resistance, UTI, Children.

scholarly journals Biofilm Formation and Extended-Spectrum Beta-Lactamase Producer among Acinetobacter Species Isolated in a Tertiary Care Hospital: A Descriptive Cross-sectional Study

2019 ◽  
Vol 57 (220) ◽  
Author(s):  
Manisha Sharma ◽  
Jyotshna Sapkota ◽  
Beena Jha ◽  
Bhavesh Mishra ◽  
Chandra Prakash Bhatt
Keyword(s):  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Low Grade ◽  
Care Hospital ◽  
Beta Lactamase ◽  
Sectional Study ◽  
Cross Sectional ◽  
Acinetobacter Species ◽  
Extended Spectrum Beta Lactamase ◽  
Extended Spectrum

Introduction: Acinetobacter species are short, stout, gram-negative coccobacilli, generally considered to be a relatively low-grade pathogen. However, its resistance towards multiple classes of antibiotics through an array of resistance mechanisms including its ability to form biofilm has led to its emergence as an important pathogen in hospital settings. This study was done to determine the prevalence of biofilm former and Extended-spectrum Beta-Lactamase producer among Acinetobacter species. Methods: A descriptive cross-sectional study was done in the clinical microbiology laboratory, Kathmandu Medical College from January to June 2019. Convenient sampling method was used. Ethical approval was taken from the Institutional Review Committee, Ref no. 2812201805. Preliminary identification followed by characterization of Acinetobacter species was done. Antibiotic susceptibility test was done using the Kirby-Bauer method following Clinical and Laboratory Standards Institute guidelines. Extended-spectrum Beta-Lactamase was detected by combined disc method and Biofilm detection was done using congo red agar method. Statistical Package for Social Sciences 16.0 version statistical software package was used for statistical analysis. Point estimate at 95% Confidence Interval was calculated along with frequencyand proportion for binarydata. Results: Among 108 Acinetobacter species, 86 (79.7%) Acinetobacter calcoaceticus-A. baumannii complex was seen. Seventy-eight (72%) of the isolates were multidrug-resistant, 34 (31%) of the isolates were Extended-spectrum Beta-Lactamase producer and only 10 (9.3%) of the isolates, were biofilm producers. Conclusions: Multidrug-resistant Acinetobacter spp. with the ability to produce Extended-spectrum Beta-Lactamase is prevalent in our hospital settings. Strict compliance with infection control practices is necessary to curb its spread.

Sign in / Sign up

Export Citation Format

Share Document