Hemostatic efficacy of human-like collagen sponge in arterioles and liver injury model

2012 ◽  
Vol 6 (10) ◽  
Author(s):  
Zhiguang Duan
Keyword(s):  
Liver Injury ◽  
Collagen Sponge ◽  
Injury Model ◽  
Hemostatic Efficacy

Hemostatic Efficacy and Biocompatibility Evaluation of a Novel Absorbable Porous Starch Hemostat

2021 ◽  
pp. 155335062110461
Author(s):  
Jianjun Zhu ◽  
Zhuona Wu ◽  
Wenzhong Sun ◽  
Zhiyun Meng ◽  
Xiaoxia Zhu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Rat Liver ◽  
Calcium Ion ◽  
Blood Compatibility ◽  
Potato Starch ◽  
Control Group ◽  
Tissue Compatibility ◽  
Injury Model ◽  
Hemostatic Efficacy

Background A novel absorbable porous starch hemostat (APSH) based on calcium ion-exchange crosslinked porous starch microparticles (Ca2+CPSM) was developed to improve hemostasis during surgeries for irregular cuts. The aim of this study was to compare its hemostatic efficacy and biocompatibility in a standard rat liver injury model relatively to Arista AH, Quickclean, and crosslinked porous starch microparticles (CPSM, without calcium ion). Methods 72 Wistar rats (220g–240 g) were randomly assigned to six groups (Arista, Quickclean, CPSM, Ca2+CPSM, native potato starch, and untreated control group, n =12 per group). 30 mg of each hemostatic agent was applied to a standard circular liver excision (8 mm in diameter and 3 mm deep) in rats. Following their hemostatic efficacy, in vivo biocompatiblity evaluation was examined. The native potato starch (NPS) group was used as the negative group. Results Ca2+CPSM had almost the same hemostatic efficacy compared with Arista; meanwhile, all the 4 hemostatic agents had good blood compatibility. In terms of in vivo tissue compatibility, Ca2+CPSM had relatively fast degradation and absorption rate with good histocompatibility. As the morphological, anatomic observation and H&E staining of liver defects after implantation, Ca2+CPSM was almost completely absorbed by liver tissue after 14 days. Conclusion According to our study, Ca2+CPSM could effectively achieve hemostasis in the standard rat liver injury model and exhibited good blood compatibility and in vivo tissue compatibility. These finding suggested that Ca2+CPSM as a new kind of APSH had its extensive clinical application value.

Regenerative potential of human pluripotent stem cell-derived MSCs in a Gunn rat liver injury model

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
LS Spitzhorn ◽  
M Megges ◽  
C Kordes ◽  
I Sawitza ◽  
S Götze ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Injury ◽  
Rat Liver ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Gunn Rat ◽  
Injury Model

scholarly journals Hemostatic efficacy of a fibrin sealant–based topical agent in a femoral artery injury model: A randomized, blinded, placebo-controlled study

1997 ◽  
Vol 26 (2) ◽  
pp. 274-280 ◽  
Author(s):  
Mark R. Jackson ◽  
Stanley A. Friedman ◽  
Andrew J. Carter ◽  
Vladislav Bayer ◽  
J.Robert Burge ◽  
...  
Keyword(s):  
Femoral Artery ◽  
Fibrin Sealant ◽  
Controlled Study ◽  
Topical Agent ◽  
Artery Injury ◽  
Injury Model ◽  
Hemostatic Efficacy

Sa1526 HEPATOCYTE-TARGETED R-SPONDIN MIMETIC STIMULATES REGENERATION AND RESTORES COAGULATION IN A THIOACETAMIDE-INDUCED LIVER INJURY MODEL

2020 ◽  
Vol 158 (6) ◽  
pp. S-1321
Author(s):  
Helene Baribault ◽  
Caroline Broderick ◽  
Haili Zhang ◽  
Hui Chen ◽  
Jay Ye ◽  
...  
Keyword(s):  
Liver Injury ◽  
Injury Model

scholarly journals A Discovery of Relevant Hepatoprotective Effects and Underlying Mechanisms of Dietary Clostridium butyricum Against Corticosterone-Induced Liver Injury in Pekin Ducks

2019 ◽  
Vol 7 (9) ◽  
pp. 358 ◽  
Author(s):  
Yanhan Liu ◽  
Cun Liu ◽  
Liqing Huang ◽  
Zhaofei Xia
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Liver Injury ◽  
Signaling Pathway ◽  
Basal Diet ◽  
Clostridium Butyricum ◽  
Pekin Ducks ◽  
Injury Model ◽  
Hepatoprotective Effects ◽  
Underlying Mechanisms

Clostridium butyricum (C. butyricum) can attenuate oxidative stress, inflammation, and hepatic fatty deposition in poultry, however, the underlying mechanisms for this in Pekin ducks remain unclear. This study evaluated these hepatoprotective effects and the underlying mechanisms in a corticosterone (CORT)-induced liver injury model in Pekin ducks fed a C. butyricum intervention diet. A total of 500 Pekin ducks were randomly divided into five groups: one group (CON group) was only provided with a basal diet, three groups were provided a basal diet with 200 mg/kg (LCB group), 400 mg/kg (MCB group), or 600 mg/kg (HCB group) C. butyricum, respectively, and one group was provided a basal diet with 150 mg/kg aureomycin (ANT group) for 42 d. At 37 days-old, all ducks received daily intraperitoneal injections of CORT for five days to establish a liver injury model. C. butyricum intervention alleviated liver injury by decreasing the liver organ indices, hepatic steatosis and hepatocyte necrosis, and improving liver function, antioxidant capacity, and inflammatory factors. Hepatic RNA-seq revealed 365 differentially expressed genes (DEGs) between the MCB and CON groups, with 229 up- and 136 down-regulated DEGs in the MCB group. Between the MCB and ANT groups, 407 DEGs were identified, including 299 up- and 108 down-regulated genes in MCB group. Some DEGs in the MCB group related to oxidative stress and inflammatory responses such as Sod3, Tlr2a/b, and Il10, which were up-regulated, while Apoa1, Cyp7a1, Acsl1/5, Fasn, Ppar-γ, and Scd, which are involved in lipid metabolism, were down-regulated, indicating that these genes were responsive to dietary C. butyricum for the alleviation of corticosterone-induced hepatic injury. Toll-like receptor signaling, PI3K-Akt signaling pathway, cytokine-cytokine receptor interaction, peroxisome proliferator-activated receptor (PPAR) signaling pathway, adipocytokine and glycerophospholipid metabolism signaling pathway were significantly enriched in the MCB group. These findings indicate that C. butyricum intervention can protect Pekin ducks from corticosterone-induced liver injury by the modulation of immunoregulatory- and lipid metabolism-related genes and pathways.

Sa1456 - Molecular Mechanisms of PDE4 Inhibition on Alcohol-Induced ER Stress and Hepatocyte Survival in an Alcoholic Liver Injury Model

2018 ◽  
Vol 154 (6) ◽  
pp. S-1119
Author(s):  
Banrida Wahlang ◽  
Walter Rodriguez-Alvarez ◽  
Yali Wang ◽  
Jingwen Zhang ◽  
Shirish Barve ◽  
...  
Keyword(s):  
Liver Injury ◽  
Er Stress ◽  
Molecular Mechanisms ◽  
Alcoholic Liver Injury ◽  
Injury Model
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