scholarly journals Antimalarial pyronaridine resistance may be associated with elevated MDR-1 gene expression profiles but not point mutation in Plasmodium berghei ANKA isolates

2020 ◽  
Vol 14 (4) ◽  
pp. 102-111
Author(s):  
Kanyonji Kimani Shadrack ◽  
Manyiwa Shume Jacob
Keyword(s):  
Gene Expression ◽  
Point Mutation ◽  
Plasmodium Berghei ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Plasmodium Berghei Anka ◽  
Mdr 1

scholarly journals Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development

2021 ◽  
Vol 118 (10) ◽  
pp. e2023438118
Author(s):  
Haikel N. Bogale ◽  
Tales V. Pascini ◽  
Sachie Kanatani ◽  
Juliana M. Sá ◽  
Thomas E. Wellems ◽  
...  
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Salivary Glands ◽  
Plasmodium Berghei ◽  
Expression Profiles ◽  
Critical Role ◽  
Gene Expression Profiles ◽  
Anatomical Site ◽  
Quiescent State

Despite the critical role of Plasmodium sporozoites in malaria transmission, we still know little about the mechanisms underlying their development in mosquitoes. Here, we use single-cell RNA sequencing to characterize the gene expression profiles of 16,038 Plasmodium berghei sporozoites isolated throughout their development from midgut oocysts to salivary glands, and from forced salivation experiments. Our results reveal a succession of tightly regulated changes in gene expression occurring during the maturation of sporozoites and highlight candidate genes that could play important roles in oocyst egress, sporozoite motility, and the mechanisms underlying the invasion of mosquito salivary glands and mammalian hepatocytes. In addition, the single-cell data reveal extensive transcriptional heterogeneity among parasites isolated from the same anatomical site, suggesting that Plasmodium development in mosquitoes is asynchronous and regulated by intrinsic as well as environmental factors. Finally, our analyses show a decrease in transcriptional activity preceding the translational repression observed in mature sporozoites and associated with their quiescent state in salivary glands, followed by a rapid reactivation of the transcriptional machinery immediately upon salivation.

1327: Gene Expression Profiles in Benign Prostatic Hyperplasia

2004 ◽  
Vol 171 (4S) ◽  
pp. 349-350
Author(s):  
Gaelle Fromont ◽  
Michel Vidaud ◽  
Alain Latil ◽  
Guy Vallancien ◽  
Pierre Validire ◽  
...  
Keyword(s):  
Gene Expression ◽  
Benign Prostatic Hyperplasia ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Prostatic Hyperplasia
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