scholarly journals A study of two weeks administration of copper sulphate on markers of renal function and feeding pattern of Wistar rats

2014 ◽  
Vol 8 (9) ◽  
pp. 158-165 ◽  
Author(s):  
O. Akomolafe Rufus ◽  
S. Olukiran Olaoluwa ◽  
E. Imafidon Chris ◽  
A. Ayannuga Olugbengba ◽  
A. Oyekunle John ◽  
...  
Keyword(s):  
Renal Function ◽  
Copper Sulphate ◽  
Wistar Rats ◽  
Feeding Pattern

The effects of rhodium on the renal function of female Wistar rats

Chemosphere ◽  
2014 ◽  
Vol 104 ◽  
pp. 120-125 ◽  
Author(s):  
Ivo Iavicoli ◽  
Veruscka Leso ◽  
Luca Fontana ◽  
Alessandro Marinaccio ◽  
Antonio Bergamaschi ◽  
...  
Keyword(s):  
Renal Function ◽  
Wistar Rats ◽  
Female Wistar Rats

scholarly journals Assessment of the toxicity and biochemical effects of detergent processed cassava on renal function of Wistar rats

2020 ◽  
Vol 7 ◽  
pp. 1103-1111
Author(s):  
G.E Oghobase ◽  
O.T Aladesanmi ◽  
R.O Akomolafe ◽  
O.S Olukiran ◽  
P.O Akano ◽  
...  
Keyword(s):  
Renal Function ◽  
Wistar Rats ◽  
Biochemical Effects

scholarly journals Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia/reperfusion injury

2018 ◽  
Vol 1864 (1) ◽  
pp. 102-114 ◽  
Author(s):  
Aline L. Cortes ◽  
Sabrina R. Gonsalez ◽  
Lilimar S. Rioja ◽  
Simone S.C. Oliveira ◽  
André L.S. Santos ◽  
...  
Keyword(s):  
Renal Function ◽  
Reperfusion Injury ◽  
Wistar Rats ◽  
Low Dose ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Acute Ischemia

scholarly journals The effects of palladium nanoparticles on the renal function of female Wistar rats

2015 ◽  
Vol 9 (7) ◽  
pp. 843-851 ◽  
Author(s):  
Luca Fontana ◽  
Veruscka Leso ◽  
Alessandro Marinaccio ◽  
Giovanna Cenacchi ◽  
Valentina Papa ◽  
...  
Keyword(s):  
Renal Function ◽  
Palladium Nanoparticles ◽  
Wistar Rats ◽  
Female Wistar Rats

scholarly journals Effects of diadenosine polyphosphates on renal function and blood pressure in anesthetized Wistar rats.

1996 ◽  
Vol 7 (8) ◽  
pp. 1216-1222
Author(s):  
H Hohage ◽  
C Reinhardt ◽  
U Borucki ◽  
G Enck ◽  
H Schlüter ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Kidney Function ◽  
Wistar Rats ◽  
Urine Flow ◽  
Diadenosine Polyphosphates ◽  
Threefold Increase ◽  
Diadenosine Triphosphate ◽  
Alpha Beta ◽  
Gamma S

In this study, the effects of diadenosine polyphosphates on kidney function were examined. Intravenous application of diadenosine hexaphosphate (AP6A) led to a significant threefold increase in both urine flow (from 2.45 +/- 0.2 to 13.8 +/- 0.74 microL/min per 100 g body wt (P < 0.05)) and Na+ excretion (from 0.41 +/- 0.12 to 1.52 +/- 0.28 mumol/min per 100 g body wt at a dose of 1.0 mg/kg body wt). In contrast, diadenosine triphosphate dose-dependently reduced urine flow (from 3.74 +/- 0.3 to 2.57 +/- 0.1 microL/min per 100 g body wt (P < 0.05)) and Na+ excretion (from 0.45 +/- 0.1 to 0.13 +/- 0.1 mumol/min per 100 g body wt at a dose of 1.0 mg/kg body wt). ATP and the P2y purinoceptor agonist gamma-S-ATP did not significantly modulate urine flow and Na+ excretion. alpha, beta-methylene-ATP, a P2x purinoceptor agonist, significantly increased urine flow from 1.74 +/- 0.5 to 4.07 +/- 1.51 microL/min per 100 g body wt, whereas Na+ excretion was unaffected. The effects were independent of alterations in GFR. Pretreatment with indomethacin (2.0 mg/kg body wt iv) completely abolished the effects of AP6A on urine flow and Na+ excretion. Similarly, pretreatment with the endothelin antagonist bosentan abolished the effects of AP6A on both urine flow and Na+ excretion, whereas suramin had no effects on the AP6A-induced increase in urine flow. In conclusion, diadenosine polyphosphates exert specific actions on urine flow and Na+ excretion that are different from the effects of ATP. AP6A may partially influence renal function by stimulating prostaglandin and endothelin release.

scholarly journals P0678RENAL SUBCAPSULAR ADMINISTRATION OF ADIPOSE DERIVED MESENCHYMAL STEM CELLS PREVENTED THE PROGRESSION OF RENAL DAMAGE IN AN EXPERIMENTAL MODEL OF CKD

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Marina P Claro ◽  
Krislley R Pereira ◽  
Everidiene K V B Silva ◽  
Flavio Teles ◽  
Paulyana F Barbosa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Renal Function ◽  
Adipose Tissue ◽  
Survival Rate ◽  
Renal Fibrosis ◽  
Wistar Rats ◽  
Tubulointerstitial Fibrosis ◽  
Renal Inflammation ◽  
Male Wistar Rats

Abstract INTRODUCTION / AIMS Chronic kidney disease (CKD) is a progressive, debilitating condition of high lethality, which prevalence have been increasing considerably in recent decades. CKD can be triggered by many different factors, such as genetic predisposition, systemic hypertension, diabetes mellitus and autoimmune diseases. It is characterized by the gradual loss of renal function, leading to kidney failure and the need for renal replacement therapy for the maintenance of life. Regardless of the etiology of CKD, the establishment of local renal inflammation, with leucocyte recruitment, cell proliferation, extracellular matrix accumulation, glomerular and tubulointerstitial fibrosis, contribute significantly to its establishment and evolution. Due to its known pathophysiology, the primary aim when clinically treating CKD is to slow the progression of renal function loss and the advance of inflammation. However, until the present moment, there is no efficient pharmacological treatment to completely arrest the aggravation of renal inflammation and, specially, renal fibrosis. This motivates the scientific community to develop experimental research in order to test new therapeutic approaches to stunt renal fibrosis. In this context, experimental application of mesenchymal stem cells (mSC) as a treatment to control renal inflammation have been showing promising results in studies with animal models of CKD. The aim of the present study was to analyze the renoprotective effects of subcapsular application of Adipose Tissue-derived mSC (ASC), in rats submitted to 5/6 nephrectomy, after the establishment of the disease (15 days after CKD induction), in order to more closely resemble the clinical settings in humans. METHODS ASC were obtained from gonadal adipose tissue from healthy male Wistar rats. These cells were cultured until P4 when characterization by flow cytometry and in vitro differentiation were performed. Male Wistar rats underwent 5/6 nephrectomy and were followed for 15 days until the complete establishment of CKD (group CKD 15d). At this time, animals underwent a new surgery in which they received a subcapsular injection of 2x106 ASC diluted in 10 μL of sterile PBS (group CKD + ASC 30d), or only 10 μL of sterile PBS (group CKD 30d). Sham-operated rats, euthanized at day 15 (Sham 15d) and 30 (Sham 30d) were used as controls. Survival rate, body weight (BW), 24h urinary protein (24h UPE) and albumin (24h UAE) excretion serum creatinine (SCr) and blood urea nitrogen (BUN) concentration, percentage (GS%) and index (GSI) of glomerulosclerosis, tubulointerstitial fibrosis (INT%) and renal infiltration by macrophages (CD68) were studied at 15 and 30 days after 5/6 nephrectomy. Our results are presented as Mean ± SE. Differences among groups were analyzed by one-way ANOVA. RESULTS ASC injection significantly improved the survival rate of CKD + ASC 30d animals, compared to the observed in the untreated group. Moreover, ASC treatment markedly reduced protein and albumin urinary excretion, prevented the development of glomerulosclerosis, both the percentage of sclerotic glomeruli and the index of glomerular damage, numerically reduced interstitial fibrosis and significantly avoided renal inflammation by halting the progression of renal cortical macrophage infiltration. CONCLUSIONS According to our results, subcapsular ASC application promoted considerable renoprotection in the 5/6 renal ablation model, even after the complete establishment of severe CKD, suggesting that experimental therapy with these cells could be associated to the current pharmacological treatments employed to detain the progression of CKD. Figure

Chronic local infusion into the renal artery of unrestrained rats

1983 ◽  
Vol 244 (2) ◽  
pp. H304-H307 ◽  
Author(s):  
J. F. Smits ◽  
C. M. Kasbergen ◽  
H. van Essen ◽  
J. C. Kleinjans ◽  
H. A. Struyker-Boudier
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Mean Arterial Pressure ◽  
Renal Artery ◽  
Wistar Rats ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Osmotic Minipump ◽  
Catheter Implantation ◽  
The Right

A method is described for providing chronic access to the right renal artery of unrestrained rats. It consists of insertion of a very thin (OD 0.2 mm) catheter into the right suprarenal artery of Wistar rats. The suprarenal artery originates from the right renal artery. After the cannula has been guided subcutaneously to the neck, it is connected to an Alzet osmotic minipump. The method has a success ratio of over 90% for periods up to 14 days. In the present study, we investigated the effects of catheter implantation on renal hemodynamics in uninephrectomized rats that were infused with saline for 2, 6, or 14 days. Values were compared with those obtained in control rats. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were estimated from plasma clearances of 51Crethylenediaminetetraacetic acid and 125I-p-aminohippuric acid, respectively. Mean arterial pressure was between 107 +/- 2 and 116 +/- 2 mmHg in all animals. Neither GFR nor ERPF was influenced by catheter implantation. It is concluded that the method does not interfere with renal function.

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