scholarly journals Safety evaluation for multispecies probiotics in a 28-day feeding study in Sprague-Dawley rats

2014 ◽  
Vol 8 (7) ◽  
pp. 127-136 ◽  
Author(s):  
Huang Chun-Chih ◽  
Nam Mun-Kit ◽  
Tsai Yueh-Ting ◽  
Tsai Cheng-Chih
Keyword(s):  
Safety Evaluation ◽  
Sprague Dawley ◽  
Feeding Study ◽  
Sprague Dawley Rats

scholarly journals Safety Evaluation of Wood–Based Activated Carbon Fibers in a 28–day Feeding Study in Sprague–Dawley Rats

2015 ◽  
Vol 60 (2) ◽  
pp. 427-434
Author(s):  
Han Chien Lin ◽  
Ji Cheng Hsueh ◽  
Wen-Ru Li ◽  
Ying-Jang Lai ◽  
She–Ching Wu ◽  
...  
Keyword(s):  
Activated Carbon ◽  
Carbon Fibers ◽  
Safety Evaluation ◽  
Activated Carbon Fibers ◽  
Sprague Dawley ◽  
Feeding Study ◽  
Sprague Dawley Rats

Toxicological evaluation of an Allium-based commercial product in a 90-day feeding study in Sprague–Dawley rats

2016 ◽  
Vol 90 ◽  
pp. 18-29 ◽  
Author(s):  
P. Mellado-García ◽  
M. Puerto ◽  
S. Pichardo ◽  
M. Llana-Ruiz-Cabello ◽  
R. Moyano ◽  
...  
Keyword(s):  
Commercial Product ◽  
Sprague Dawley ◽  
Toxicological Evaluation ◽  
Feeding Study ◽  
Sprague Dawley Rats

Safety evaluation of a standardized phytochemical composition extracted from Bacopa monnieri in Sprague–Dawley rats

2007 ◽  
Vol 45 (10) ◽  
pp. 1928-1937 ◽  
Author(s):  
J. Joshua Allan ◽  
A. Damodaran ◽  
N.S. Deshmukh ◽  
K.S. Goudar ◽  
A. Amit
Keyword(s):  
Safety Evaluation ◽  
Bacopa Monnieri ◽  
Sprague Dawley ◽  
Phytochemical Composition ◽  
Sprague Dawley Rats

Subchronic feeding study of herbicide–tolerant soybean DP-356Ø43-5 in Sprague–Dawley rats

2008 ◽  
Vol 46 (6) ◽  
pp. 2201-2213 ◽  
Author(s):  
Laura M. Appenzeller ◽  
Susan M. Munley ◽  
Denise Hoban ◽  
Greg P. Sykes ◽  
Linda A. Malley ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Feeding Study ◽  
Sprague Dawley Rats ◽  
Herbicide Tolerant

Spontaneous Necrotizing Hepatic Arteriopathy in Male Sprague-Dawley Rats

2020 ◽  
Vol 48 (7) ◽  
pp. 905-908
Author(s):  
Tracy Carlson ◽  
Lily Yee
Keyword(s):  
Hepatic Artery ◽  
Evaluation Studies ◽  
Safety Evaluation ◽  
Vascular Wall ◽  
Sprague Dawley ◽  
Control Male ◽  
Perivascular Edema ◽  
Sprague Dawley Rats ◽  
Safety Studies ◽  
Microscopic Features

Differentiating test article–related vascular changes from spontaneous findings is important for microscopic interpretation in drug safety evaluation studies intended for regulatory submission. Here, we report background spontaneous hepatic artery degeneration and necrosis in up to 20% of 3- to 9-month-old control male Sprague-Dawley rats in 23 individual safety studies. The vascular degeneration occurred in one cross section of a medium-sized hepatic artery near the hilus and ranged from acute intramural hemorrhage and fibrinoid necrosis to chronic fibrosis of the vascular wall with perivascular edema, hemorrhage, and inflammatory cell infiltrates. The cause was uncertain. Many microscopic features were consistent with systemic necrotizing arteriopathy (SNA) or polyarteritis; however, there was no change in arteries commonly affected in SNA/polyarteritis (mesenteric, pancreatic, or testicular arteries) and hepatic artery degeneration/necrosis occurred in younger rats which is unusual for SNA/polyarteritis. Spontaneous hepatic artery degeneration/necrosis represents a sporadic background finding that may be confused with a test article’s toxicologic effect.

Safety evaluation of the human-identical milk monosaccharide sialic acid (N-acetyl-d-neuraminic acid) in Sprague-Dawley rats

2014 ◽  
Vol 70 (2) ◽  
pp. 482-491 ◽  
Author(s):  
Sharon S.H. Choi ◽  
Nigel Baldwin ◽  
Valentine O. Wagner ◽  
Shambhu Roy ◽  
Jennifer Rose ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Safety Evaluation ◽  
Neuraminic Acid ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Subchronic feeding study of DAS-59122-7 maize grain in Sprague-Dawley rats

2007 ◽  
Vol 45 (7) ◽  
pp. 1277-1292 ◽  
Author(s):  
Linda A. Malley ◽  
Nancy E. Everds ◽  
Julia Reynolds ◽  
Peter C. Mann ◽  
Ian Lamb ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Feeding Study ◽  
Sprague Dawley Rats ◽  
Maize Grain

Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague–Dawley rats

2007 ◽  
Vol 45 (4) ◽  
pp. 551-562 ◽  
Author(s):  
Susan A. MacKenzie ◽  
Ian Lamb ◽  
Jean Schmidt ◽  
Lora Deege ◽  
Michael J. Morrisey ◽  
...  
Keyword(s):  
Transgenic Maize ◽  
Sprague Dawley ◽  
Feeding Study ◽  
Sprague Dawley Rats ◽  
Maize Grain
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