scholarly journals Comparative study of single nucleotide polymorphisms (SNPs) of a candidate growth gene (IGF-I) in Oreochromis niloticus and Sarotherodon melanotheron

2020 ◽  
Vol 19 (8) ◽  
pp. 546-555
Author(s):  
B. A. Sokenu ◽  
O. R. Oguntade ◽  
L. A. Ogunkanmi ◽  
T. O. Oketoki ◽  
E. A. Ukenye ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Comparative Study ◽  
Oreochromis Niloticus ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Igf I ◽  
Sarotherodon Melanotheron

scholarly journals Novel single nucleotide polymorphisms in candidate genes for growth in tilapia ( Oreochromis niloticus )

2016 ◽  
Vol 45 (6) ◽  
pp. 345-348
Author(s):  
Breidy Lizeth Cuevas-Rodríguez ◽  
Ana María Sifuentes-Rincón ◽  
Pascuala Ambriz-Morales ◽  
Manuel García-Ulloa ◽  
Francisco Javier Valdez-González ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Candidate Genes ◽  
Oreochromis Niloticus ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Analysis of Somatostatin Receptors 2 and 5 Polymorphisms in Patients with Acromegaly

2005 ◽  
Vol 90 (8) ◽  
pp. 4824-4828 ◽  
Author(s):  
M. Filopanti ◽  
C. Ronchi ◽  
E. Ballarè ◽  
S. Bondioni ◽  
A. G. Lania ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Somatostatin Receptor ◽  
Somatostatin Receptors ◽  
Somatostatin Analogs ◽  
Minor Role ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Igf I ◽  
A Minor ◽  
Serum Gh

Objective: The aim of the study was to investigate the possible correlation of single nucleotide polymorphisms in somatostatin receptor (SSTR)2 and SSTR5 genes with the responsiveness to somatostatin analogs in a cohort of acromegalic patients. Study Design: Three single nucleotide polymorphisms (a-83 g, c-57 g, and t80c) of SSTR2 and three (t-461c, c325t, and c1004t) of SSTR5 were analyzed in 66 acromegalic patients with different responsiveness to somatostatin analogs and 66 healthy controls. Results: Allele frequencies in patients and controls were similar. No association between SSTR2 genotypes and GH and IGF-I levels was found. When considering SSTR5 variants, patients homozygous or heterozygous for the substitution c1004 (P+) showed basal IGF-I levels significantly lower than patients homozygous for 1004t (P−). Moreover, serum GH levels were lower in patients with P+/T− haplotype (having c1004 allele and no t-461 allele) than in those with P−/T+. No correlation between SSTR2 and SSTR5 genotypes, responsiveness to somatostatin therapy, and mRNA expression in the removed adenomas (n = 10) was found. Conclusions: These data suggest a role for SSTR5 t–461c and c1004t alleles in influencing GH and IGF-I levels in patients with acromegaly, whereas SSTR2 and SSTR5 variants seem to have a minor role in determining the responsiveness to somatostatin analogs.

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