scholarly journals Application of polymeric nanoparticles for controlled release of ethanolic extract of guapeva leaves (Pouteria gardneriana Radlk) against Riphicephalus (Boophilus) microplus through in vitro studies

2016 ◽  
Vol 15 (49) ◽  
pp. 2778-2786 ◽  
Author(s):  
Fernanda Pereira Barbosa Priscila ◽  
Peres de Mendonça Pablo ◽  
Davi Albuquerque Andrade Rômulo ◽  
Carolina Ribeiro Aguiar Ana ◽  
Rodrigues Chaves Andréa ◽  
...  
Keyword(s):  
Controlled Release ◽  
Polymeric Nanoparticles ◽  
Ethanolic Extract ◽  
Boophilus Microplus ◽  
In Vitro Studies

scholarly journals Fabrication of PLA-PEG Nanoparticles as Delivery Systems for Improved Stability and Controlled Release of Catechin

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Neha Atulkumar Singh ◽  
Abul Kalam Azad Mandal ◽  
Zaved Ahmed Khan
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Hydrodynamic Diameter ◽  
Sem Image ◽  
Oral Delivery System ◽  
Improved Stability

The purpose of this study was to develop an oral delivery system for the controlled release of catechin and evaluate the antioxidant potential and stability of catechin loaded PLA/PEG nanoparticles (CATNP). Nanoparticles were synthesized using a double emulsion solvent evaporation method. The fabricated nanoparticles were relatively small with a hydrodynamic diameter of 300 nm and an encapsulation efficiency of 95%. SEM image analysis showed uniform sized and spherically shaped nanoparticles. In vitro release profiles indicated a slow and sustained release of catechin from the nanoparticle. Stability of the nanoparticle in simulated gastric and intestinal fluids is maintained due to the PEG coating on the nanoparticles, which effectively protected catechin against gastrointestinal enzyme activity. Enhanced inhibition action of free radicals and metal chelation potential was noted when catechin was encapsulated in these polymeric nanoparticles. The reports obtained from this study would provide an opportunity for designing an oral delivery system aimed at inhibiting oxidative stress in the human body.

scholarly journals HYDROGEL FORMULATION FROM CALOTROPIS GIGANTEA PLANT EXTRACT AGAINST FOOT ULCER CAUSING BACTERIA IN DIABETES

2021 ◽  
pp. 96-99
Author(s):  
RAMACHANDRAN AM ◽  
SENTHIL PRABHU S ◽  
DEVAKUMAR J ◽  
RENGARAMANUJAM J ◽  
KARTHIK SUNDARAM S ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Plant Extract ◽  
Foot Ulcer ◽  
Ethanolic Extract ◽  
In Vitro Studies ◽  
Inhibitory Zone ◽  
Control Groups ◽  
Calotropis Gigantea ◽  
Hydrogel Formulation

Objective: The objective of present study was to develop hydrogel formulations loaded with Calotropis gigantea leaves extract. Methods: The prepared hydrogel formulations were compliance with their color, odor, homogeneity, pH, and spreadability. Results: As all the formulations were complies with the all parameters and it can be suggest as a Good antibacterial gel. It is evident that, ethanolic extract of Calotropis gigantea showed a maximum inhibitory zone against bacteria associated with foot ulcer. Conclusions: The In vitro studies showed a quantity dependent increase in antibacterial activity against foot ulcer causing bacteria, a contraction which is higher than that produced by the control groups. These contractions were statistically significant (p<0.05), during the study with leave extract against foot ulcer causing bacteria in diabetes.

scholarly journals In-vitro studies on antioxidant and antidiabetic potential of Sesoot (Garcinia picrorrhiza Miq.) fruit ethanolic extract from Indonesia

Pharmaciana ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 273
Author(s):  
Sri Utami ◽  
Sonny Pamuji Laksono ◽  
Qomariyah Romadhiyani Sachrowardi ◽  
Dewi Nurul Mustaqimah ◽  
Susi Endrini ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
In Vitro Studies

scholarly journals Antioxidant Effects of Quercetin and Catechin Encapsulated into PLGA Nanoparticles

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Hector Pool ◽  
David Quintanar ◽  
Juan de Dios Figueroa ◽  
Camila Marinho Mano ◽  
J. Etelvino H. Bechara ◽  
...  
Keyword(s):  
Controlled Release ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Antioxidant Properties ◽  
Differential Pulse ◽  
Plga Nanoparticles ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Release Profiles

Polymeric nanoparticles (PLGA) have been developed for the encapsulation and controlled release of quercetin and catechin. Nanoparticles were fabricated using a solvent displacement method. Physicochemical properties were measured by light scattering, scanning electron microscopy andζ-potential, X-ray diffraction, infrared spectroscopy and differential scanning calorimetry. Encapsulation efficiency andin vitrorelease profiles were obtained from differential pulse voltammetry experiments. Antioxidant properties of free and encapsulated flavonoids were determined by TBARS, fluorescence spectroscopy and standard chelating activity methods. Relatively small (d≈ 400 nm) polymeric nanoparticles were obtained containing quercetin or catechin in a non-crystalline form (EE≈79%) and the main interactions between the polymer and each flavonoid were found to consist of hydrogen bonds.In vitrorelease profiles were pH-dependant, the more acidic pH, the faster release of each flavonoid from the polymeric nanoparticles. The inhibition of the action of free radicals and chelating properties, were also enhanced when quercetin and catechin were encapsulated within PLGA nanoparticles. The information obtained from this study will facilitate the design and fabrication of polymeric nanoparticles as possible oral delivery systems for encapsulation, protection and controlled release of flavonoids aimed to prevent oxidative stress in human body or food products.

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