scholarly journals Lipid lowering and anti-atherosclerotic properties of Tinospora crispa aqueous extract on high-cholesterol diet-induced hyperlipidemic rabbits

2015 ◽  
Vol 14 (34) ◽  
pp. 2604-2610
Author(s):  
M S Zamree ◽  
Safwan K Ihsan ◽  
Kamilah A K Khairul ◽  
Kamal N H Mohd ◽  
M A Rasadah ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

scholarly journals Effect of lutein on lipid profile in hypercholesterolemic rats

2018 ◽  
Vol 7 (5) ◽  
pp. 859
Author(s):  
Uma Narayanamurthy ◽  
Anandhi M. ◽  
Manimekalai K.
Keyword(s):  
Fatty Infiltration ◽  
Treated Group ◽  
Lipid Lowering ◽  
Ldl Oxidation ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Chow Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Group I

Background: Hyperlipidemia or Dyslipidemia is the major cause of atherosclerosis1 and associated conditions. Low levels of high-density-lipoprotein cholesterol (HDL-C) are the major causes of increased atherogenic risk 1. Aggressive cholesterol reduction in patients with atherosclerotic disease is now the standard of care2. In addition to life style modification, patients with risk factors need lipid lowering drug therapy. The drugs available now do not reduce LDL oxidation, and oxidative stress associated with hyperlipidemia. In recent years, antioxidants have been subjected to epidemiological studies4 that have related their consumption to a reduction in the incidence of oxidative damage related diseases.Methods: Hypercholesterolemia was induced in rats by administration of high cholesterol diet for 30 days in standard rat chow diet. Rats were divided into four groups of six each. Group-I and II with intake of normal diet and High cholesterol diet respectively. Group III and IV are given high cholesterol diet along with Lutein 50mg/kg and Atorvastatin 5mg/kg orally once daily respectively. At the end of 30 days animals were subjected to overnight fasting. Blood samples were drawn by retro-orbital puncture for biochemical analysis. The animals were sacrificed after thiopentone injection and liver and aorta were dissected out and processed for histopathological study and biochemical analysis.Results: Lutein treated group showed even more significant reduction in TBARS levels than the normal control group and Atorvastatin treated group. The efficacy of Lutein in slowing down the atherosclerosis and fatty infiltration of liver is proved in this study.Conclusions: Hence the present study had shown significant hypolipidemic, antiatherogenic and antioxidant effect of Luetin in Hyperlipidemic rats. 

scholarly journals In VivoHypocholesterolemic Effect of MARDI Fermented Red Yeast Rice Water Extract in High Cholesterol Diet Fed Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Swee Keong Yeap ◽  
Boon Kee Beh ◽  
Joan Kong ◽  
Wan Yong Ho ◽  
Hamidah Mohd Yusof ◽  
...  
Keyword(s):  
Water Extract ◽  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
Red Yeast Rice ◽  
Monacolin K ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Red Yeast ◽  
Rice Water

Fermented red yeast rice has been traditionally consumed as medication in Asian cuisine. This study aimed to determine thein vivohypocholesterolemic and antioxidant effects of fermented red yeast rice water extract produced using Malaysian Agricultural Research and Development Institute (MARDI)Monascus purpureusstrains in mice fed with high cholesterol diet. Absence of monacolin-k, lower level ofγ-aminobutyric acid (GABA), higher content of total amino acids, and antioxidant activities were detected in MARDI fermented red yeast rice water extract (MFRYR).In vivoMFRYR treatment on hypercholesterolemic mice recorded similar lipid lowering effect as commercial red yeast rice extract (CRYR) as it helps to reduce the elevated serum liver enzyme and increased the antioxidant levels in liver. This effect was also associated with the upregulation of apolipoproteins-E and inhibition of Von Willebrand factor expression. In summary, MFRYR enriched in antioxidant and amino acid without monacolin-k showed similar hypocholesterolemic effect as CRYR that was rich in monacolin-k and GABA.

Effects of citrus latifolia extract on dyslipidemia and tissues redox status in rats fed a high-cholesterol diet

2019 ◽  
Vol 49 (6) ◽  
pp. 989-999 ◽  
Author(s):  
Hakima Mir ◽  
Djamil Krouf ◽  
Nawal Taleb-Dida ◽  
Sadia Berzou ◽  
Akila Guenzet ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Aqueous Extract ◽  
Thiobarbituric Acid ◽  
Redox Status ◽  
Primary Treatment ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Content Type ◽  
Citrus Latifolia

Purpose This study aims to investigate the possible effect of Citrus latifolia (CL) extract on biomarkers of oxidative stress, including lipid peroxidation products in rats fed a high cholesterol diet Design/methodology/approach Hypercholesterolemia was induced by feeding normocholesterolemic rats 1 per cent cholesterol-enriched diet for 15 days. An experimental group (n = 20) was divided into two groups (n = 10) and fed the same diet with or without CL lyophilized aqueous extract (1 per cent) for four weeks. At day 28, ten rats from each group were killed. Findings Treatment with CL lyophilized aqueous extract compared with the untreated group had decreased plasma total cholesterol (TC) (−36 per cent), triacylglycerols (−48 per cent), isoprostanes values (−74 per cent) and reduced thiobarbituric acid reactive substances in erythrocytes (−21 per cent). However, the supplementation of CL peels in the hypercholesterolemic diet enhanced superoxide dismutase (+69 per cent), glutathione reductase (+30 per cent) and catalase activities (+34 per cent). Originality/value In hypercholesterolemic rats, administering CL extract ameliorates dyslipidemia and attenuates lipid peroxidation in tissues. These results suggest that CL could be beneficial in the primary treatment of hypercholesterolemia and oxidative damage caused by a high-cholesterol diet.

Lipid-Lowering Effect of Eriocitrin, the Main Flavonoid in Lemon Fruit, in Rats on a High-Fat and High-Cholesterol Diet

2006 ◽  
Vol 71 (9) ◽  
pp. S633-S637 ◽  
Author(s):  
Yoshiaki Miyake ◽  
Eriko Suzuki ◽  
Satoko Ohya ◽  
Syuichi Fukumoto ◽  
Masanori Hiramitsu ◽  
...  
Keyword(s):  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Lemon Fruit ◽  
Lowering Effect ◽  
Lipid Lowering Effect

scholarly journals Comparison of the Protective Effects of Individual Components of Particulatedtrans-Sialidase (PTCTS), PTC and TS, against High Cholesterol Diet-Induced Atherosclerosis in Rabbits

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Shérrira M. Garavelo ◽  
Maria de Lourdes Higuchi ◽  
Jaqueline J. Pereira ◽  
Marcia M. Reis ◽  
Joyce T. Kawakami ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Abdominal Aorta ◽  
Oxidized Ldl ◽  
Rabbit Model ◽  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
Protective Effects ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Plaque Area

Previous studies showed the presence ofMycoplasma pneumoniae(M. pneumoniae) and membrane-shed microparticles (MPs) in vulnerable atherosclerotic plaques. H&S Science and Biotechnology developed PTCTS, composed by natural particles from medicinal plants (PTC) combined withtrans-Sialidase (TS), to combat MPs andMycoplasma pneumoniae. Our aim was to determine the effects of the different components of PTCTS in a rabbit model of atherosclerosis. Rabbits were fed with high cholesterol diet for 12 weeks and treated during the last 6 weeks with either vehicle, PTC, TS, or PTCTS. Lipid profile and quantification of MPs positive forMycoplasma pneumoniaeand oxidized LDL antigens were carried out. Aortas and organs were then histologically analyzed. PTCTS reduced circulating MPs positive forMycoplasma pneumoniaeand oxidized LDL antigens, reduced the plaque area in the abdominal aorta, and caused positive remodeling of the ascendant aorta. PTC caused positive remodeling and reduced plaque area in the abdominal aorta; however, TS had a lipid lowering effect. PTCTS components combined were more effective against atherosclerosis than individual components. Our data reinforce the infectious theory of atherosclerosis and underscore the potential role of circulating MPs. Therefore, the removal ofMycoplasma-derived MPs could be a new therapeutic approach in the treatment of atherosclerosis.

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