scholarly journals Analysis of mtDNA hypervariable region II for increasing the discrimination power from Middle and South of Iraq

2015 ◽  
Vol 14 (10) ◽  
pp. 843-850 ◽  
Author(s):  
Omran Hussein Ameera ◽  
Abdulhasan Kareem Muhanned ◽  
Hadi Hameed Imad
Keyword(s):  
Hypervariable Region ◽  
Discrimination Power ◽  
South Of Iraq ◽  
Region Ii

scholarly journals mtDNA hypervariable region II (HVII) sequences in human evolution studies

2000 ◽  
Vol 8 (12) ◽  
pp. 964-974 ◽  
Author(s):  
Antonio Salas ◽  
Victoria Lareu ◽  
Francesc Calafell ◽  
Jaume Bertranpetit ◽  
Ángel Carracedo
Keyword(s):  
Human Evolution ◽  
Hypervariable Region ◽  
Region Ii

scholarly journals Pattern of Nucleotide Substitution and Rate Heterogeneity in the Hypervariable Regions I and II of Human mtDNA

Genetics ◽  
1999 ◽  
Vol 152 (3) ◽  
pp. 1103-1110 ◽  
Author(s):  
Sonja Meyer ◽  
Gunter Weiss ◽  
Arndt von Haeseler
Keyword(s):  
Nucleotide Substitution ◽  
Hypervariable Region ◽  
Likelihood Methods ◽  
Rate Heterogeneity ◽  
Hypervariable Regions ◽  
Region I ◽  
Maximum Likelihood Methods ◽  
Comprehensive Survey ◽  
Hypervariable Region I ◽  
Region Ii

Abstract This study provides a comprehensive survey of the complex pattern of nucleotide substitution in the control region of human mtDNA, which is of central importance to the studies of human evolution. A total of 1229 different hypervariable region I (HVRI) and 385 different hypervariable region II (HVRII) sequences were analyzed using a complex substitution model. Moreover, we suggest a new method to assign relative rates to each site in the sequence. Estimates are based on maximum-likelihood methods applied to randomly selected subsets of sequences. Our results indicate that the rate of substitution in HVRI is approximately twice as high as in HVRII and that this difference is mainly due to a higher frequency of pyrimidine transitions in HVRI. However, rate heterogeneity is more pronounced in HVRII.

Sequencing Human Mitochondrial Hypervariable Region II as a Molecular Fingerprint for Environmental Waters

2014 ◽  
Vol 48 (18) ◽  
pp. 10648-10655 ◽  
Author(s):  
Vikram Kapoor ◽  
Ronald W. DeBry ◽  
Dominic L. Boccelli ◽  
David Wendell
Keyword(s):  
Hypervariable Region ◽  
Environmental Waters ◽  
Molecular Fingerprint ◽  
Region Ii

scholarly journals DNA sequence of the mitochondrial hypervariable region II from the Neandertal type specimen

1999 ◽  
Vol 96 (10) ◽  
pp. 5581-5585 ◽  
Author(s):  
M. Krings ◽  
H. Geisert ◽  
R. W. Schmitz ◽  
H. Krainitzki ◽  
S. Paabo
Keyword(s):  
Dna Sequence ◽  
Hypervariable Region ◽  
Type Specimen ◽  
Region Ii

Localization of cell-surface and basement-membrane heparan-sulfate proteoglycans using the malaria circumsporozoite protein

1994 ◽  
Vol 52 ◽  
pp. 294-295
Author(s):  
U. Frevert ◽  
S. Sinnis ◽  
C. Cerami ◽  
V. Nussenzweig
Keyword(s):  
Heparan Sulfate ◽  
Protein A ◽  
Kidney Tissue ◽  
Plasmodium Species ◽  
Its Region ◽  
Basement Membranes ◽  
Heparan Sulfate Proteoglycans ◽  
Infected Mosquito ◽  
Complement Components ◽  
Region Ii

Malaria sporozoites, which invade hepatocytes within minutes after transmission by an infected mosquito, are covered with the circumsporozoite (CS) protein, which in all Plasmodium species contains the conserved region II-plus. This region is also found as a cell-adhesive motif in a variety of host proteins like thrombospondin, properdin and the terminal complement components.The CS protein with its region II-plus specifically binds to heparan sulfate proteoglycans (HSPG) on the basolateral surface of hepatocytes in the space of Disse (FIG. 1), to certain basolateral cell membranes and basement membranes of the kidney (FIG. 2) as well as to heparin in the granules of connective tissue mast cells. The distribution of the HSPG receptors for the CS protein was examined by incubation of Lowicryl K4M or LR White sections of liver and kidney tissue with the recombinant CS ligand, whose binding sites were detected with a monoclonal anti-CS antibody and protein A gold.

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