scholarly journals Chemical composition, anti-inflammatory and analgesic activities of the petrol ether extract of Pinellia cordata

2011 ◽  
Vol 10 (53) ◽  
pp. 11023-11027 ◽  
Author(s):  
Huang Baokang ◽  
Chu Zhiyong ◽  
He Weiping ◽  
Qin Luping
Keyword(s):  
Chemical Composition ◽  
Ether Extract ◽  
Anti Inflammatory ◽  
Analgesic Activities ◽  
Petrol Ether

Comparative Analysis of In-Vitro Biological Activities of Methyl Eugenol Rich Cymbopogon khasianus Hack., Leaf Essential Oil with Pure Methyl Eugenol Compound

2020 ◽  
Vol 21 (10) ◽  
pp. 927-938 ◽  
Author(s):  
Roktim Gogoi ◽  
Rikraj Loying ◽  
Neelav Sarma ◽  
Twahira Begum ◽  
Sudin K. Pandey ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Biological Activities ◽  
Methyl Eugenol ◽  
Dpph Assay ◽  
Pure Compound ◽  
Allium Cepa Assay ◽  
Anti Inflammatory ◽  
Lemongrass Essential Oil

Background: The essential oil of methyl eugenol rich Cymbopogon khasianus Hack. was evaluated and its bioactivities were compared with pure methyl eugenol. So far, methyl eugenol rich essential oil of lemongrass was not studied for any biological activities; hence, the present study was conducted. Objective: This study examined the chemical composition of essential oil of methyl eugenol rich Cymbopogon khasianus Hack., and evaluated its antioxidant, anti-inflammatory, antimicrobial, and herbicidal properties and genotoxicity, which were compared with pure compound, methyl eugenol. Material and Methods: Methyl eugenol rich variety of Cymbopogon khasianus Hack., with registration no. INGR18037 (c.v. Jor Lab L-9) was collected from experimental farm CSIR-NEIST, Jorhat, Assam (26.7378°N, 94.1570°E). The essential oil wasobtained by hydro-distillation using a Clevenger apparatus. The chemical composition of the essential oil was evaluated using GC/MS analysis and its antioxidant (DPPH assay, reducing power assay), anti-inflammatory (Egg albumin denaturation assay), and antimicrobial (Disc diffusion assay, MIC) properties, seed germination effect and genotoxicity (Allium cepa assay) were studied and compared with pure Methyl Eugenol compound (ME). Results: Major components detected in the Essential Oil (EO) through Gas chromatography/mass spectroscopy analysis were methyl eugenol (73.17%) and β-myrcene (8.58%). A total of 35components were detected with a total identified area percentage of 98.34%. DPPH assay revealed considerable antioxidant activity of methyl eugenol rich lemongrass essential oil (IC50= 2.263 μg/mL), which is lower than standard ascorbic acid (IC50 2.58 μg/mL), and higher than standard Methyl Eugenol (ME) (IC50 2.253 μg/mL). Methyl eugenol rich lemongrass EO showed IC50 38.00 μg/mL, ME 36.44 μg/mL, and sodium diclofenac 22.76 μg/mL, in in-vitro anti-inflammatory test. Moderate antimicrobial activity towards the 8 tested microbes was shown by methyl eugenol rich lemongrass essential oil whose effectiveness against the microbes was less as compared to pure ME standard. Seed germination assay further revealed the herbicidal properties of methyl eugenol rich essential oil. Moreover, Allium cepa assay revealed moderate genotoxicity of the essential oil. Conclusion: This paper compared the antioxidant, anti-inflammatory, antimicrobial, genotoxicity and herbicidal activities of methyl eugenol rich lemongrass with pure methyl eugenol. This methyl eugenol rich lemongrass variety can be used as an alternative of methyl eugenol pure compound. Hence, the essential oil of this variety has the potential of developing cost-effective, easily available antioxidative/ antimicrobial drugs but its use should be under the safety range of methyl eugenol and needs further clinical trials.

Design, Synthesis and Pharmacological Evaluation of Novel Antiinflammatory and Analgesic O-Benzyloxime Compounds Derived From Natural Eugenol

2019 ◽  
Vol 16 (10) ◽  
pp. 1157-1166
Author(s):  
Rodrigo César da Silva ◽  
Fabiano Veiga ◽  
Fabiana Cardoso Vilela ◽  
André Victor Pereira ◽  
Thayssa Tavares da Silva Cunha ◽  
...  
Keyword(s):  
Formalin Test ◽  
Docking Studies ◽  
Paw Edema ◽  
Inhibitory Effects ◽  
Structural Pattern ◽  
Design Synthesis ◽  
Drug Candidates ◽  
Anti Inflammatory ◽  
Analgesic Activities ◽  
Cox 1

Background: : A new series of O-benzyloximes derived from eugenol was synthesized and was evaluated for its antinociceptive and anti-inflammatory properties. Methods: : The target compounds were obtained in good global 25-28% yields over 6 steps, which led us to identify compounds (Z)-5,6-dimethoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one-O-(4- (methylthio)benzyloxime (8b), (Z)-5,6-dimethoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one-O-4- bromobenzyloxime (8d) and (Z)-5,6-dimethoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one-O-4- (methylsulfonyl)benzyloxime (8f) as promising bioactive prototypes. Results:: These compounds have significant analgesic and anti-inflammatory effects, as evidenced by formalin-induced mice paw edema and carrageenan-induced mice paw edema tests. In the formalin test, compounds 8b and 8f evidenced both anti-inflammatory and direct analgesic activities and in the carrageenan-induced paw edema, with compounds 8c, 8d, and 8f showing the best inhibitory effects, exceeding the standard drugs indomethacin and celecoxib. Conclusion: : Molecular docking studies have provided additional evidence that the pharmacological profile of these compounds may be related to inhibition of COX enzymes, with slight preference for COX-1. These results led us to identify the new O-benzyloxime ethers 8b, 8d and 8f as orally bioactive prototypes, with a novel structural pattern capable of being explored in further studies aiming at their optimization and development as drug candidates.

scholarly journals Prediction of metabolizable energy values in poultry offal meal for broiler chickens

2010 ◽  
Vol 39 (10) ◽  
pp. 2237-2245 ◽  
Author(s):  
Edney Pereira da Silva ◽  
Carlos Bôa-Viagem Rabello ◽  
Luiz Fernando Teixeira Albino ◽  
Jorge Victor Ludke ◽  
Michele Bernardino de Lima ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Broiler Chickens ◽  
Crude Protein ◽  
Matter Content ◽  
Metabolizable Energy ◽  
Mineral Matter ◽  
Ether Extract ◽  
High Fat ◽  
Collection Method ◽  
Gross Energy

This research aimed at generating and evaluating prediction equations to estimate metabolizable energy values in poultry offal meal. The used information refers to values of apparent and true metabolizable energy corrected for nitrogen balance (AMEn and TMEn) and for chemical composition of poultry offal meal. The literature review only included published papers on poultry offal meal developed in Brazil, and that had AMEn and TMEn values obtained by the total excreta collection method from growing broiler chickens and the chemical composition in crude protein (CP), ether extract (EE), mineral matter (MM), gross energy (GE), calcium (Ca) and phosphorus (P). The general equation obtained to estimate AMEn values of poultry offal meal was: AMEn = -2315.69 + 31.4439(CP) + 29.7697(MM) + 0.7689(GE) - 49.3611(Ca), R² = 72%. For meals with high fat contents (higher than 15%) and low mineral matter contents (lower than 10%), it is suggest the use of the equation AMEn = + 3245.07 + 46.8428(EE), R² = 76%, and for meals with high mineral matter content (higher than 10%), it is suggest the equations AMEn = 4059.15 - 440.397(P), R² = 82%. To estimate values of TMEn, it is suggested for meals with high mineral matter content the equation: TMEn = 5092.57 - 115.647(MM), R² = 78%, and for those with low contents of this component, the option is the equation: TMEn = 3617.83 - 15.7988(CP) - 18.2323(EE) - 96.3884(MM) + 0.4874(GE), R² = 76%.

Essential oil of Myrciaria tenella (DC.) O. Berg: effects of distillation time on its chemical composition and evaluation of its anti-inflammatory and antinociceptive effects

2021 ◽  
pp. 1-16
Author(s):  
Gabriela Mastrangelo Gonçalves ◽  
Víctor de Carvalho Martins ◽  
André Romero Henrique da Costa ◽  
Thayane Ferreira da Costa Fernandes ◽  
Sidney Pacheco ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Antinociceptive Effects ◽  
Anti Inflammatory

Chemical composition and anti-inflammatory activities of the essential oils fromAcacia mearnsiide Wild

2014 ◽  
Vol 29 (12) ◽  
pp. 1184-1188 ◽  
Author(s):  
Opeyemi N. Avoseh ◽  
Ope-oluwa O. Oyedeji ◽  
Kayode Aremu ◽  
Benedicta N. Nkeh-Chungag ◽  
Sandile P. Songca ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oils ◽  
Anti Inflammatory

The anti-inflammatory and analgesic activities of the ethyl acetate extract of Viburnum taitoense Hayata

2021 ◽  
Vol 269 ◽  
pp. 113742
Author(s):  
Xinduo Wu ◽  
Jizhao Xie ◽  
Li Qiu ◽  
Luhui Zou ◽  
Yunfeng Huang ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Anti Inflammatory ◽  
Analgesic Activities

scholarly journals Chemical Composition, Allelopathic, Antioxidant, and Anti-Inflammatory Activities of Sesquiterpenes Rich Essential Oil of Cleome amblyocarpa Barratte & Murb.

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1294
Author(s):  
Ahmed M. Abd-ElGawad ◽  
Abdelbaset M. Elgamal ◽  
Yasser A. EI-Amier ◽  
Tarik A. Mohamed ◽  
Abd El-Nasser G. El Gendy ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Climatic Conditions ◽  
Chemometric Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Authentic Materials ◽  
Dactyloctenium Aegyptium ◽  
Hexahydrofarnesyl Acetone ◽  
Ic50 Values ◽  
Anti Inflammatory

The integration of green natural chemical resources in agricultural, industrial, and pharmaceutical applications allures researchers and scientistic worldwide. Cleome amblyocarpa has been reported as an important medicinal plant. However, its essential oil (EO) has not been well studied; therefore, the present study aimed to characterize the chemical composition of the C. amblyocarpa, collected from Egypt, and assess the allelopathic, antioxidant, and anti-inflammatory activities of its EO. The EO of C. amblyocarpa was extracted by hydrodistillation and characterized via gas chromatography–mass spectrometry (GC-MS). The chemometric analysis of the EO composition of the present studied ecospecies and the other reported ecospecies was studied. The allelopathic activity of the EO was evaluated against the weed Dactyloctenium aegyptium. Additionally, antioxidant and anti-inflammatory activities were determined. Forty-eight compounds, with a prespondence of sesquiterpenes, were recorded. The major compounds were caryophyllene oxide (36.01%), hexahydrofarnesyl acetone (7.92%), alloaromadendrene epoxide (6.17%), myrtenyl acetate (5.73%), isoshyobunone (4.52%), shyobunol (4.19%), and trans-caryophyllene (3.45%). The chemometric analysis revealed inconsistency in the EO composition among various studied ecospecies, where it could be ascribed to the environmental and climatic conditions. The EO showed substantial allelopathic inhibitory activity against the germination, seedling root, and shoot growth of D. aegyptium, with IC50 values of 54.78, 57.10, and 74.07 mg L−1. Additionally, the EO showed strong antioxidant potentiality based on the IC50 values of 4.52 mg mL−1 compared to 2.11 mg mL−1 of the ascorbic acid as standard. Moreover, this oil showed significant anti-inflammation via the suppression of lipoxygenase (LOX) and cyclooxygenases (COX1, and COX2), along with membrane stabilization. Further study is recommended for analysis of the activity of pure authentic materials of the major compounds either singularly or in combination, as well as for evaluation of their mechanism(s) and modes of action as antioxidants or allelochemicals.

Identification of phytoconstituents of Tragia involucrata leaf extracts and evaluate their correlation with anti-inflammatory & antioxidant properties

2021 ◽  
Vol 20 ◽  
Author(s):  
Vinodhini Velu ◽  
Swagata Banerjee ◽  
Vidya Rajendran ◽  
Gaurav Gupta ◽  
Dinesh Kumar Chellappan ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Ethyl Acetate ◽  
Petroleum Ether ◽  
Ethyl Acetate Extract ◽  
Petroleum Ether Extract ◽  
Inflammatory Activity ◽  
Ether Extract ◽  
Membrane Stabilization ◽  
Leaf Extracts ◽  
Anti Inflammatory

Aims: The present investigation was aimed at exploring the phytoconstituents using Gas Chromatography Mass Spectroscopy and to evaluate antioxidant and anti-inflammatory properties of the leaf extracts. Materials and Methods: The extracts were obtained sequentially with petroleum ether, ethyl acetate and water using soxhlet apparatus. The anti-inflammatory property of the identified compounds using GC- MS spectroscopy was evaluated in silico. The antioxidant activity was performed by DPPH and H2O2 method whereas anti-inflammatory study was carried out by HRBC membrane stabilization method. Terpenoids were found to be major constituents in petroleum ether extract while, phenols and flavonoids were predominantly found in ethyl acetate extract. Results and Discussion: The GC-MS analysis of the extract revealed six major molecules including Squalene, 19β, 28- epoxyleanan-3-ol and 2-tu-Butyl-5-chloromethyl-3-methyl-4-oxoimidazolidine-1-carboxylic acid. The ethyl acetate extract showed a significant antioxidant activity (P<0.01) in both DPPH method (70.87 %) and H2O2 method (73.58%) at 200 µg mL-1 . Increased membrane stabilization of petroleum ether extract was observed in the in vitro anti-inflammatory activity study. A strong relationship between the terpenoid content and anti-inflammatory activity was obtained from the correlation (0.971) and docking study. Conclusion: These results justify T. involucrata to be a rich source of terpenoids with potent antiinflammatory property.

scholarly journals Chemical composition, antioxidant and topical anti-inflammatory activities of Croton cordiifolius Baill. (Euphorbiaceae)

2017 ◽  
Vol 11 (2) ◽  
pp. 22-33 ◽  
Author(s):  
Andreza Basilio dos Santos Alves Iasmine ◽  
Maria dos Santos Simone ◽  
Frankilin Vasconcelos Mendes Raudiney ◽  
Wellinton da Silva José ◽  
de Fátima Rodrigues Maria ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Anti Inflammatory
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