Plasma malondialdehyde, bilirubin, homocysteine and total antioxidant capacity in patients with angiographically defined coronary artery disease

2012 ◽  
Vol 11 (13) ◽  
Author(s):  
Ali Movahed
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Total Antioxidant ◽  
Artery Disease ◽  
Plasma Malondialdehyde

Antioxidant status and risk of coronary artery disease

2019 ◽  
Vol 49 (4) ◽  
pp. 700-712 ◽  
Author(s):  
Shokoofeh Talebi ◽  
Zamzam Paknahad ◽  
Mohammad Hashemi ◽  
Akbar Hasanzadeh
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Content Type ◽  
Total Antioxidant ◽  
Artery Disease ◽  
Artery Obstruction

Purpose Coronary artery disease (CAD) is developed by an insufficient supply of oxygen-rich blood to the myocardium. Recent studies have shown that increased oxidative stress has implicated in the pathogenesis of coronary atherosclerosis. Anxiety and CAD have a mutual relationship, as the effect of long-lasting anxiety on atherosclerosis and CAD is well known. The purpose of this study is to investigate the relationship between dietary / serum total antioxidant capacity and CAD. Design/methodology/approach A total of 160 male patients were enrolled in this cross-sectional study. Diagnosis and analysis of angiograms were performed visually by a cardiologist. The subjects were categorized into CAD− (coronary artery obstruction <75 per cent) and CAD+ (coronary artery obstruction ≥ 75 per cent) groups. Anthropometric indices, blood pressure, blood sugar and lipid profile and physical activity (PA) were assessed. Information about anxiety was obtained by Spielberger questionnaire. Dietary total antioxidant capacity (TAC) was obtained by using a semi-quantitative food frequency questionnaire and an oxygen radical absorbance capacity of selected foods. Findings Mean of dietary TAC was significantly lower in CAD+ than CAD− group (P < 0.001). However, there was not any significant differences about serum TAC (P = 0.28). The mean of body mass index (BMI) (P = 0.04) and triglyceride (TG) level (P = 0.03) and the frequency of smoking (P = 0.03) were significantly higher in the CAD+ than the CAD− group. There was no significant relationship between CAD with apparent (P = 0.33) and hidden anxiety level (P = 0.16). Confounding factors such as smoking and medications were adjusted. Research limitations/implications This study had certain limitations. Being a single center cross-sectional design does not permit analysis of causal relationships; the sample size was geographically limited. The authors could not exclude the medication of patients, which could affect the total antioxidant capacity levels. Measurement error in self-reported dietary consumption may results misclassification of exposure. Practical implications A diet high in total antioxidant capacity is inversely associated with CAD. Serum TAC does not vary between men with and without CAD when confounders including age, BMI, TG, smoking, SBP, DBP, energy intake, PA, HDL-C, LDL-C, T-C, FBS, family history of CAD, education and anxiety are taken into consideration. Social implications High consumption of vegetables and fruits may play a major role in the prevention of CAD. Originality/value The study was approved by the ethics committee of Isfahan University of Medical Sciences (No:394888).

scholarly journals Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease

2008 ◽  
Vol 156 (6) ◽  
pp. 1201.e1-1201.e11 ◽  
Author(s):  
Renate Schnabel ◽  
Edith Lubos ◽  
Claudia M. Messow ◽  
Christoph R. Sinning ◽  
Tanja Zeller ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Antioxidant Capacity ◽  
Selenium Supplementation ◽  
Artery Disease

scholarly journals A Study of Effects of Addition of Coenzyme Q 10 to High Dose Statins in Patients of Coronary Artery Disease with Special Reference to Oxidative Balance

2017 ◽  
Vol 02 (01) ◽  
pp. 006-013
Author(s):  
Malleswara Dangeti ◽  
Siva Katkam ◽  
Raghu Galla ◽  
Ravi Kiran ◽  
Indrani Garre
Keyword(s):  
Oxidative Stress ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Statin Therapy ◽  
Coenzyme Q10 ◽  
Coenzyme Q ◽  
High Dose ◽  
Plasma Glutathione ◽  
Artery Disease ◽  
Plasma Malondialdehyde

AbstractBackground: Oxidative stress is one of the most potent inductors of endothelial dysfunction and is involved at all stages of atherosclerotic plaque evolution. Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are beneficial in the primary and secondary prevention of coronary heart disease. Statins also possess direct free radical scavenging activity. However, the prooxidant effect of statins has also been reported as statins block the mevalonate pathway and the synthesis coenzyme Q10. This Additional Coenzyme Q10 depletion by statins in patients with coronary artery disease (CAD) may be a critical issue as it may reduce absolute benefits of statins.Objectives: The purpose of this study was to investigate the effects of high dose statins on plasma Malondialdehyde (MDA) levels and plasma glutathione levels in CAD patients who underwent recent PCI and to study whether addition of coenzyme Q10 (100 mg/d) has any additional effect on plasma Malondialdehyde (MDA) levels and plasma glutathione levels in patients already receiving high dose statin therapy.Methods: Twenty-one consecutive patients who underwent percutaneous transluminal coronary angioplasty (PTCA) in Department of Cardiology at our institute were studied. The cases (n = 21) were given high dose statins for first 1 week and then coenzyme Q10 (100 md /day) is added for next 1 week. Plasma Malondialdehyde(MDA) levels and plasma glutathione levels were analyzed at the time of admission before giving statins and at the end of 1 week of statin therapy and again after 1 week of Co-Q therapy.Results: Our results indicate that a relation exists between high plasma Malondialdehyde (MDA) levels and low plasma glutathione levels with coronary artery disease. High dose statins decrease MDA levels and increase plasma glutathione levels, even though they decrease coenzyme q levels in the body. It was also shown that addition of Coenzyme Q10 at 100 mg/d enhances plasma glutathione levels and decreases plasma MDA level still further in patients who have CAD, already receiving high dose statin therapy.Conclusions: Addition of Coenzyme Q10 at 100 mg/d has an additive effect with high dose statins in decreasing oxidative stress. Particularly in light of the excellent tolerance and affordability of this natural physiological compound, supplemental Coenzyme Q10 may emerge as an attractive option in future, and merits evaluation in additional large studies.

Increased plasma malondialdehyde and protein carbonyl levels and lymphocyte DNA damage in patients with angiographically defined coronary artery disease

2005 ◽  
Vol 38 (12) ◽  
pp. 1059-1065 ◽  
Author(s):  
Ümit Mutlu-Türkoðlu ◽  
Zülal Akalýn ◽  
Ebru Ýlhan ◽  
Ercüment Yýlmaz ◽  
Ahmet Bilge ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Dna Damage ◽  
Coronary Artery ◽  
Protein Carbonyl ◽  
Artery Disease ◽  
Plasma Malondialdehyde
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