Protective effects of rooibos (Aspalathus linearis), green tea (Camellia sinensis) and commercial supplements on testicular tissue of oxidative stress-induced rats

2011 ◽  
Vol 10 (75) ◽  
Author(s):  
D. O. Awoniyi
Keyword(s):  
Oxidative Stress ◽  
Green Tea ◽  
Camellia Sinensis ◽  
Testicular Tissue ◽  
Protective Effects ◽  
Aspalathus Linearis

scholarly journals Green Tea and Epigallocatechin Gallate (EGCG) for the Management of Nonalcoholic Fatty Liver Diseases (NAFLD): Insights into the Role of Oxidative Stress and Antioxidant Mechanism

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1076
Author(s):  
Guoyi Tang ◽  
Yu Xu ◽  
Cheng Zhang ◽  
Ning Wang ◽  
Huabin Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Liver ◽  
Green Tea ◽  
Liver Diseases ◽  
Randomized Clinical Trials ◽  
Epigallocatechin Gallate ◽  
Protective Effects ◽  
Nonalcoholic Fatty Liver ◽  
Nonalcoholic Fatty Liver Diseases ◽  
Underlying Mechanisms

Nonalcoholic fatty liver diseases (NAFLD) represent a set of liver disorders progressing from steatosis to steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma, which induce huge burden to human health. Many pathophysiological factors are considered to influence NAFLD in a parallel pattern, involving insulin resistance, oxidative stress, lipotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, inflammatory cascades, fibrogenic reaction, etc. However, the underlying mechanisms, including those that induce NAFLD development, have not been fully understood. Specifically, oxidative stress, mainly mediated by excessive accumulation of reactive oxygen species, has participated in the multiple NAFLD-related signaling by serving as an accelerator. Ameliorating oxidative stress and maintaining redox homeostasis may be a promising approach for the management of NAFLD. Green tea is one of the most important dietary resources of natural antioxidants, above which epigallocatechin gallate (EGCG) notably contributes to its antioxidative action. Accumulative evidence from randomized clinical trials, systematic reviews, and meta-analysis has revealed the beneficial functions of green tea and EGCG in preventing and managing NAFLD, with acceptable safety in the patients. Abundant animal and cellular studies have demonstrated that green tea and EGCG may protect against NAFLD initiation and development by alleviating oxidative stress and the related metabolism dysfunction, inflammation, fibrosis, and tumorigenesis. The targeted signaling pathways may include, but are not limited to, NRF2, AMPK, SIRT1, NF-κB, TLR4/MYD88, TGF-β/SMAD, and PI3K/Akt/FoxO1, etc. In this review, we thoroughly discuss the oxidative stress-related mechanisms involved in NAFLD development, as well as summarize the protective effects and underlying mechanisms of green tea and EGCG against NAFLD.

Evaluation of renal protective effects of the green-tea (EGCG) and red grape resveratrol: role of oxidative stress and inflammatory cytokines

2011 ◽  
Vol 25 (8) ◽  
pp. 850-856 ◽  
Author(s):  
A.M. El-Mowafy ◽  
H.A. Salem ◽  
M.M. Al-Gayyar ◽  
M.E. El-Mesery ◽  
M.F. El-Azab
Keyword(s):  
Oxidative Stress ◽  
Green Tea ◽  
Inflammatory Cytokines ◽  
Protective Effects ◽  
Red Grape

Novel chemotherapeutic and renal protective effects for the green tea (EGCG): Role of oxidative stress and inflammatory-cytokine signaling

Phytomedicine ◽  
2010 ◽  
Vol 17 (14) ◽  
pp. 1067-1075 ◽  
Author(s):  
A.M. El-Mowafy ◽  
M.M. Al-Gayyar ◽  
H.A. Salem ◽  
M.E. El-Mesery ◽  
M.M. Darweish
Keyword(s):  
Oxidative Stress ◽  
Green Tea ◽  
Inflammatory Cytokine ◽  
Cytokine Signaling ◽  
Protective Effects

scholarly journals Ameliorative effects of crocin on paraquat-induced oxidative stress in testis of adult mice: An experimental study

2019 ◽  
Author(s):  
Fahime Sadat Kamali ◽  
Rasoul Shahrooz ◽  
Golamreza Najafi ◽  
Mazdak Razi
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Properties ◽  
B Cell Lymphoma ◽  
Testicular Tissue ◽  
Control Group ◽  
Protective Effects ◽  
Adult Mice ◽  
Oxidative Damages ◽  
Sham Control Group ◽  
Annual Weeds

Background: Paraquat (PQ), as a pyridine compound, is widely used worldwide to control annual weeds. The oxidative stress caused by PQ can cause deleterious changes in the testicular tissue. Objective: An investigation on the protective effects of Crocin (CCN) against PQinduced oxidative damages and apoptotic indices in testicular tissue. Materials and Methods: Twenty-eight adult male albino mice (20-25 gr) were divided into four groups (n = 7/each). The control group received 0.1 ml/day of normal saline by intraperitoneal injection (IP); sham-control group received PQ 5 mg/kg/day, IP, and the experimental groups received PQ (CCN+PQ) and CCN-sole (200 mg/kg/day, IP), respectively, for 35 continuous days. At the end of the treatment period, the testes were dissected out and used for biochemical, molecular, and histological analyses. The expressions of tumor suppressor p53, B-cell lymphoma 2 (bcl-2), and caspase-3 were considered as hallmark factors of mitochondria-dependent apoptosis. Moreover, the testicular superoxide dismutase (SOD) and malondialdehyde (MDA) were evaluated as key biomarkers for oxidative stress. Results: The PQ significantly (p < 0.02, p < 0.01) diminished the spermatogenesis indices and SOD, increased MDA levels, and enhanced the apoptosis-related gene expression. However, the co-administration of CCN and PQ significantly (p < 0.01, p < 0.01, p < 0.02) ameliorated the spermatogenesis ratio, upregulated the SOD level as well as bcl-2 expression, and reduced the MDA content and apoptosis vs the PQ-sole group. Conclusion: This study showed that the antioxidant properties of CCN enable to ameliorate the PQ-induced destructive effects by upregulating the testicular structure, antioxidant and apoptotic status. Key words: Histology, Testis, Paraquat, Crocin, Mice.

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