Antimicrobial activity of camwood (Baphia nitida) dyes on common human pathogens

2012 ◽  
Vol 11 (26) ◽  
Author(s):  
O. K. Agwa
Keyword(s):  
Antimicrobial Activity ◽  
Human Pathogens

scholarly journals Highlighting the Biotechnological Potential of Deep Oceanic Crust Fungi through the Prism of Their Antimicrobial Activity

Marine Drugs ◽  
2021 ◽  
Vol 19 (8) ◽  
pp. 411
Author(s):  
Maxence Quemener ◽  
Marie Dayras ◽  
Nicolas Frotté ◽  
Stella Debaets ◽  
Christophe Le Meur ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Oceanic Crust ◽  
Gene Clusters ◽  
Multidrug Resistant ◽  
Antimicrobial Activities ◽  
Antimicrobial Compounds ◽  
Human Pathogens ◽  
Biotechnological Potential ◽  
Fungal Isolates

Among the different tools to address the antibiotic resistance crisis, bioprospecting in complex uncharted habitats to detect novel microorganisms putatively producing original antimicrobial compounds can definitely increase the current therapeutic arsenal of antibiotics. Fungi from numerous habitats have been widely screened for their ability to express specific biosynthetic gene clusters (BGCs) involved in the synthesis of antimicrobial compounds. Here, a collection of unique 75 deep oceanic crust fungi was screened to evaluate their biotechnological potential through the prism of their antimicrobial activity using a polyphasic approach. After a first genetic screening to detect specific BGCs, a second step consisted of an antimicrobial screening that tested the most promising isolates against 11 microbial targets. Here, 12 fungal isolates showed at least one antibacterial and/or antifungal activity (static or lytic) against human pathogens. This analysis also revealed that Staphylococcus aureus ATCC 25923 and Enterococcus faecalis CIP A 186 were the most impacted, followed by Pseudomonas aeruginosa ATCC 27853. A specific focus on three fungal isolates allowed us to detect interesting activity of crude extracts against multidrug-resistant Staphylococcus aureus. Finally, complementary mass spectrometry (MS)-based molecular networking analyses were performed to putatively assign the fungal metabolites and raise hypotheses to link them to the observed antimicrobial activities.

scholarly journals Comparison of Methods of Extraction and Antimicrobial Activity of Six Ocimum Species against Human Pathogens

2018 ◽  
Vol 5 (2) ◽  
Author(s):  
Manjula Bomma ◽  
Florence Okafor ◽  
S.R. Mentreddy ◽  
Leopold Nyochembeng ◽  
William Setzer ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Comparison Of Methods ◽  
Human Pathogens ◽  
Ocimum Species

scholarly journals Production of an Engineered Killer Peptide in Nicotiana benthamiana by Using a Potato virus X Expression System

2005 ◽  
Vol 71 (10) ◽  
pp. 6360-6367 ◽  
Author(s):  
Marcello Donini ◽  
Chiara Lico ◽  
Selene Baschieri ◽  
Stefania Conti ◽  
Walter Magliani ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Pseudomonas Syringae ◽  
Potato Virus ◽  
Broad Spectrum ◽  
Plant Pathogens ◽  
Expression System ◽  
Potato Virus X ◽  
Scale Production ◽  
Human Pathogens ◽  
Single Chain

ABSTRACT The decapeptide killer peptide (KP) derived from the sequence of a single-chain, anti-idiotypic antibody acting as a functional internal image of a microbicidal, broad-spectrum yeast killer toxin (KT) was shown to exert a strong microbicidal activity against human pathogens. With the aim to exploit this peptide to confer resistance to plant pathogens, we assayed its antimicrobial activity against a broad spectrum of phytopathogenic bacteria and fungi. Synthetic KP exhibited antimicrobial activity in vitro towards Pseudomonas syringae, Erwinia carotovora, Botrytis cinerea, and Fusarium oxysporum. KP was also expressed in plants by using a Potato virus X (PVX)-derived vector as a fusion to the viral coat protein, yielding chimeric virus particles (CVPs) displaying the heterologous peptide. Purified CVPs showed enhanced antimicrobial activity against the above-mentioned plant pathogens and human pathogens such as Staphylococcus aureus and Candida albicans. Moreover, in vivo assays designed to challenge KP-expressing plants (as CVPs) with Pseudomonas syringae pv. tabaci showed enhanced resistance to bacterial attack. The results indicate that the PVX-based display system is a high-yield, rapid, and efficient method to produce and evaluate antimicrobial peptides in plants, representing a milestone for the large-scale production of high-added-value peptides through molecular farming. Moreover, KP is a promising molecule to be stably engineered in plants to confer broad-spectrum resistance to phytopathogens.

Thermo-chemical induced production of silver nanoparticles (Ag-NPs) and their antimicrobial activity towards human pathogens

2017 ◽  
Vol 10 (5) ◽  
pp. 1322
Author(s):  
S. Krishnakumar ◽  
R. Divya ◽  
N.R. Kanchana Devi ◽  
G. Keerthana ◽  
A. Ancy Judi
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Human Pathogens ◽  
Ag Nps

scholarly journals In vitro study on screening antimicrobial and anti-oxidant potential of Ramalina fastigiata

2019 ◽  
Vol 9 (1) ◽  
pp. 216-219 ◽  
Author(s):  
Sureshrajan Soundararajan ◽  
Poornima Shanmugam ◽  
Nagarjun Nagarajan ◽  
Divya Palanisamy ◽  
Ponmurugan Ponnusamy
Keyword(s):  
Antimicrobial Activity ◽  
Tamil Nadu ◽  
Radical Scavenging ◽  
In Vitro Study ◽  
Acetone Extract ◽  
Klebsiella Pneumonia ◽  
Human Pathogens ◽  
Phytochemical Study ◽  
Anti Oxidant

The aim of the present study is to investigate the antimicrobial and anti-oxidant potential of lichen Ramalina fastigiata collected from Kolli hills, Eastern Gahts of Tamil Nadu, India. Phytochemical study revealed that acetone extract of Ramalina fastigiata confirmed the presence of flavonoids, glycosides and phenols. Acetone extract of Ramalina fastigiata was tested against human pathogens, which exposed antimicrobial activity against Klebsiella pneumonia and Candida krusei with the inhibition rate of 2.1 mm and 1.3 mm respectively. The acetone extract of lichen Ramalina fastigiata exhibited significant antioxidant activity as well. Radical scavenging ability of Ramalina fastigiata was reported in terms of 61.53 % inhibition. Keywords: Lichen, Ramalina fastigiata, acetone extract, antimicrobial activity, anti-inflammatory potential

scholarly journals Antioxidant and antimicrobial activity of different plant parts of Anacardium occidentale L. and Mangifera indica L.: a comparative study

2019 ◽  
Vol 11 (04) ◽  
Author(s):  
S. L. Sija ◽  
A. S. Athulya ◽  
M. R. Mahima ◽  
Ashok Vidhya
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Mangifera Indica ◽  
Radical Scavenging ◽  
Clinical Importance ◽  
Salmonella Typhi ◽  
Anacardium Occidentale ◽  
Human Pathogens ◽  
Young Leaves

Anacardium occidentale L. and Mangifera indica L. has been used worldwide both for pharmaceutical, food and cosmetic industries due to the presence of biological activities of some of its metabolites. The present study comprises the correlation of antioxidant activity and antimicrobial activity in ethyl acetate extract of young leaves and bark of A. occidentale and M. indica. The activity of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) on radical scavenging effect of the extracts was carried out by spectrophotometrically. All the plant extracts showed DPPH radical scavenging activity and among the extracts, A. occidentale young leaves indicated higher antioxidant potential in comparison with those of the other extracts. The antibacterial activity of various extracts was also screened against some human pathogens of clinical importance; Pseudomonas aeruginosa; Salmonella typhi; Bacillus subtilis; Escherichia coli and Staphylococcus aureus.

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