Prime obsession: Bernhard Riemann and the greatest unsolved problem in mathematics

2003 ◽  
Vol 41 (03) ◽  
pp. 41-1600-41-1600
2005 ◽  
Vol 73 (3) ◽  
pp. 287-288 ◽  
Author(s):  
John Derbyshire ◽  
Mark P. Silverman

2015 ◽  
Vol 9 (1) ◽  
pp. 59-87 ◽  
Author(s):  
Martin Calamari

In recent years, the ideas of the mathematician Bernhard Riemann (1826–66) have come to the fore as one of Deleuze's principal sources of inspiration in regard to his engagements with mathematics, and the history of mathematics. Nevertheless, some relevant aspects and implications of Deleuze's philosophical reception and appropriation of Riemann's thought remain unexplored. In the first part of the paper I will begin by reconsidering the first explicit mention of Riemann in Deleuze's work, namely, in the second chapter of Bergsonism (1966). In this context, as I intend to show first, Deleuze's synthesis of some key features of the Riemannian theory of multiplicities (manifolds) is entirely dependent, both textually and conceptually, on his reading of another prominent figure in the history of mathematics: Hermann Weyl (1885–1955). This aspect has been largely underestimated, if not entirely neglected. However, as I attempt to bring out in the second part of the paper, reframing the understanding of Deleuze's philosophical engagement with Riemann's mathematics through the Riemann–Weyl conjunction can allow us to disclose some unexplored aspects of Deleuze's further elaboration of his theory of multiplicities (rhizomatic multiplicities, smooth spaces) and profound confrontation with contemporary science (fibre bundle topology and gauge field theory). This finally permits delineation of a correlation between Deleuze's plane of immanence and the contemporary physico-mathematical space of fundamental interactions.


Metals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 709
Author(s):  
Uwe Zerbst ◽  
Mauro Madia ◽  
Giovanni Bruno ◽  
Kai Hilgenberg

The safe fatigue design of metallic components fabricated by additive manufacturing (AM) is still a largely unsolved problem. This is primarily due to (a) a significant inhomogeneity of the material properties across the component; (b) defects such as porosity and lack of fusion as well as pronounced surface roughness of the as-built components; and (c) residual stresses, which are very often present in the as-built parts and need to be removed by post-fabrication treatments. Such morphological and microstructural features are very different than in conventionally manufactured parts and play a much bigger role in determining the fatigue life. The above problems require specific solutions with respect to the identification of the critical (failure) sites in AM fabricated components. Moreover, the generation of representative test specimens characterized by similar temperature cycles needs to be guaranteed if one wants to reproducibly identify the critical sites and establish fatigue assessment methods taking into account the effect of defects on crack initiation and early propagation. The latter requires fracture mechanics-based approaches which, unlike common methodologies, cover the specific characteristics of so-called short fatigue cracks. This paper provides a discussion of all these aspects with special focus on components manufactured by laser powder bed fusion (L-PBF). It shows how to adapt existing solutions, identifies fields where there are still gaps, and discusses proposals for potential improvement of the damage tolerance design of L-PBF components.


2021 ◽  
Vol 128 (3) ◽  
pp. 214-237
Author(s):  
Jan E. Holly ◽  
David Krumm
Keyword(s):  

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shay Laps ◽  
Fatima Atamleh ◽  
Guy Kamnesky ◽  
Hao Sun ◽  
Ashraf Brik

AbstractDespite six decades of efforts to synthesize peptides and proteins bearing multiple disulfide bonds, this synthetic challenge remains an unsolved problem in most targets (e.g., knotted mini proteins). Here we show a de novo general synthetic strategy for the ultrafast, high-yielding formation of two and three disulfide bonds in peptides and proteins. We develop an approach based on the combination of a small molecule, ultraviolet-light, and palladium for chemo- and regio-selective activation of cysteine, which enables the one-pot formation of multiple disulfide bonds in various peptides and proteins. We prepare bioactive targets of high therapeutic potential, including conotoxin, RANTES, EETI-II, and plectasin peptides and the linaclotide drug. We anticipate that this strategy will be a game-changer in preparing millions of inaccessible targets for drug discovery.


2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Stefanie Behnke ◽  
Thomas Schlechtriemen ◽  
Andreas Binder ◽  
Monika Bachhuber ◽  
Mark Becker ◽  
...  

Abstract Background The prehospital identification of stroke patients with large-vessel occlusion (LVO), that should be immediately transported to a thrombectomy capable centre is an unsolved problem. Our aim was to determine whether implementation of a state-wide standard operating procedure (SOP) using the Los Angeles Motor Scale (LAMS) is feasible and enables correct triage of stroke patients to hospitals offering (comprehensive stroke centres, CSCs) or not offering (primary stroke centres, PSCs) thrombectomy. Methods Prospective study involving all patients with suspected acute stroke treated in a 4-month period in a state-wide network of all stroke-treating hospitals (eight PSCs and two CSCs). Primary endpoint was accuracy of the triage SOP in correctly transferring patients to CSCs or PSCs. Additional endpoints included the number of secondary transfers, the accuracy of the LAMS for detection of LVO, apart from stroke management metrics. Results In 1123 patients, use of a triage SOP based on the LAMS allowed triage decisions according to LVO status with a sensitivity of 69.2% (95% confidence interval (95%-CI): 59.0–79.5%) and a specificity of 84.9% (95%-CI: 82.6–87.3%). This was more favourable than the conventional approach of transferring every patient to the nearest stroke-treating hospital, as determined by geocoding for each patient (sensitivity, 17.9% (95%-CI: 9.4–26.5%); specificity, 100% (95%-CI: 100–100%)). Secondary transfers were required for 14 of the 78 (17.9%) LVO patients. Regarding the score itself, LAMS detected LVO with a sensitivity of 67.5% (95%-CI: 57.1–78.0%) and a specificity of 83.5% (95%-CI: 81.0–86.0%). Conclusions State-wide implementation of a triage SOP requesting use of the LAMS tool is feasible and improves triage decision-making in acute stroke regarding the most appropriate target hospital.


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