scholarly journals Calcium Intake and Serum Calcium Level in Relation to the Risk of Ischemic Stroke: Findings from the REGARDS Study

2019 ◽  
Vol 21 (3) ◽  
pp. 312-323 ◽  
Author(s):  
Daniel T. Dibaba ◽  
Pengcheng Xun ◽  
Alyce D. Fly ◽  
Aurelian Bidulescu ◽  
Cari L. Tsinovoi ◽  
...  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Rahel D. Gebreyohannes ◽  
Ahmed Abdella ◽  
Wondimu Ayele ◽  
Ahizechukwu C. Eke

Abstract Background Preeclampsia is a well-known cause of maternal mortality and morbidity in Ethiopia. The exact pathophysiology has not been fully understood. Calcium and magnesium deficiencies have been given emphasis to play roles in the pathophysiology. Although evidence is abundant, they are equivocal. The study aimed to see the association of dietary calcium intake, serum total calcium level and ionized calcium level with preeclampsia. It also evaluated the association between dietary calcium intake and serum calcium levels. Materials and methods An unmatched case–control study was conducted in Gandhi Memorial, Tikur Anbessa, and Zewditu Memorial Hospitals, all in Addis Ababa, between October to December, 2019. Cases were 42 women with preeclampsia and controls were 42 normotensive women. The medical and obstetric history was gathered using a structured questionnaire and the dietary calcium intake information using a 24-h dietary recall. The serum levels of total serum calcium and ionized (free) calcium were measured using an inductively coupled mass spectrophotometer. Bivariate and multivariate logistic regression and Pearson correlation test were utilized during data analysis. Results In comparison with controls, women with preeclampsia had lower mean (± 1SD) levels of ionized calcium level (1.1 mmol/l ± 0.11), total serum calcium level (1.99 mmol/l ± 0.35) and lower median (IQR) dietary calcium intake (704 mg/24 h,458–1183). The odds of having preeclampsia was almost eight times greater in those participants with low serum ionized calcium level (OR 7.5, 95% CI 2.388–23.608) and three times higher in those with low total serum calcium level (OR 3.0, 95% CI 1.024–9.370). Low dietary calcium intake also showed statistically significant association with preeclampsia (OR 3.4, 95% CI 1.092 -10.723). Serum ionized calcium level and total serum calcium level showed positive correlation of moderate strength (p = 0.004, r = 0.307), but no correlation was found between dietary calcium intake with both forms of serum calcium levels. Conclusion This study showed significant association between low dietary calcium intake and low serum calcium levels with preeclampsia, hence this can be used as a supportive local evidence for the current context-specific recommendation of calcium supplementation in societies with low-dietary calcium consumption in an attempt to prevent preeclampsia, therefore implementation study should be considered in Ethiopia to look for the feasibility of routine supplementation.


2011 ◽  
Vol 165 (3) ◽  
pp. 429-434 ◽  
Author(s):  
J Saltevo ◽  
Leo Niskanen ◽  
Hannu Kautiainen ◽  
Jorma Teittinen ◽  
Heikki Oksa ◽  
...  

BackgroundThe aim of this cross-sectional study was to examine the association between serum calcium and the components of metabolic syndrome (MetS).MethodsAs a part of the national prevention program of diabetes in Finland (FIN-D2D), a randomly selected study population of 4500 middle-aged men and women were recruited from three central hospital district areas. Anthropometric measurements were performed by a trained nurse. An oral glucose tolerance test was performed and serum calcium and lipids were measured. We assessed current medications, physical activity, smoking, alcohol consumption, calcium intake, and vitamin D intake. The MetS was defined according to the criteria of the updated National Education Program. The study population consisted of 2896 individuals: 1396 men (62% of invited individuals) and 1500 women (66.7% of invited individuals).ResultsThe mean age was 60.3±8.3 years in men and 59.8±8.5 years in women. The prevalence of MetS was 50.7% in women and 55.8% in men. The prevalence of MetS and its components, except high-density lipoprotein (HDL)-cholesterol, increased linearly with increasing serum calcium (P<0.001), even after adjustment for age, physical activity, alcohol, vitamin D intake, calcium intake, and smoking. The threshold value for serum calcium for MetS was 2.50 mmol/l in this population. The association of MetS with total serum calcium was similar even after exclusion of patients treated with hypertensive drugs. The drug treatments for hypertension, dyslipidemia, and diabetes increased in a similar pattern.ConclusionsSerum calcium level is associated with MetS and its components, except HDL-cholesterol.


2019 ◽  
Vol 9 (4) ◽  
pp. 795-803 ◽  
Author(s):  
Shashi Kant ◽  
Partha Haldar ◽  
Anant Gupta ◽  
Ayush Lohiya

Background: Calcium requirement increases during pregnancy, thereby increasing the chances of developing hypocalcaemia. Hypocalcaemia may be associated with pregnancy-related complications. Therefore, we planned this study to estimate the prevalence of hypocalcaemia among pregnant women attending secondary care hospital, and to study the association between hypocalcaemia and pregnancy outcomes. Materials and Methods: This study was conducted in a secondary level hospital at Ballabgarh, district Faridabad, Haryana, India. Consecutive pregnant women with gestation period more than 28 weeks were enrolled. Dietary calcium intake was ascertained using 24-hour dietary recall method. Serum calcium estimation was done by Biolis 24i auto analyser. Outcome of pregnancy (preterm delivery, low birth weight (LBW) babies, and neonatal mortality) was assessed telephonically 3 months after the enrolment. Results: A total of 696 pregnant women were enrolled in the study. Mean (SD) dietary calcium intake and serum calcium level was 796.4 (360.4) mg/day and 9.56 (0.94) mg/dl respectively. Prevalence (95% CI) of hypocalcaemia was 23.9% (20.8 – 27.2%). Serum total calcium level was not associated with dietary calcium intake (p-value – 0.36). Mean serum calcium level was significantly lower in mothers who had LBW babies. Pre-eclampsia, preterm delivery, and neonatal mortality were not associated with serum calcium level. Conclusion: Serum calcium level may not be related to dietary calcium level. Hence, the current recommendation of calcium supplementation during antenatal period appears to be inconclusive among our study population.


2008 ◽  
Vol 51 (4) ◽  
pp. B37
Author(s):  
Fiona Byrne ◽  
Sinead Kinsella ◽  
J.A. Eustace

2018 ◽  
Vol 25 (02) ◽  
pp. 297-301
Author(s):  
Lal Badshah ◽  
Asim Khan ◽  
Shahida Malik

Objectives: Objective of this study is to assess the correlation between severityof ischemic stroke on NIHSS and calcium level in patients presented with acute ischemic stroke.Study Design: Descriptive case series and non-probability purposive sampling technique wasused in this study. Setting: South Medical ward& East Medical Ward, Department of Medicine,Mayo hospital, Lahore. Period: One year from 5th January 2015 to 4th January 2016. Material &Methods: Informed consent was taken from all the patients. Patients of both genders between35-70 years of age were included in this study. Demographic record (name, age, sex, contact)were also obtained. Then patients were admitted in ward and were followed up there. Meanwhileno calcium supplement was advised. Then after 72 hours of admission, blood sample weredrawn by using 5cc BD syringe and were sent to the laboratory of the hospital to assess serumcalcium level. NIHSS score after 72 hours of admission were assessed and noted. Pearsoncorrelation coefficient was calculated to measure the correlation between calcium level andNIHSS score. P-value≤0.05 were considered as significant. Results: In this present studythe mean age of the patients was noted as 51.47±9.653 years, the male patients were 76%whereas female patients were 24%. The mean serum calcium level after 72 hours of the patientswas noted as 7.26±1.41 mg/dl, while the man NIHSS was noted as 23.01±10.38.There wasnegative and Significant correlation was found between the serum calcium level (mg/dl) after72 hours and NIHSS after 72 hours of the patients i.e. r=-0.899 (P<0.05). Conclusion: Ourstudy results showed the negative correlation between the serum calcium level and NIHSS ofischemic stroke patients which showed that more decrease in calcium level will lead to moresevere condition of stroke.


1983 ◽  
Vol 31 (5) ◽  
pp. 725-729
Author(s):  
Mitsuru Tsuchida ◽  
Hideomi Iida ◽  
Hajime Ishikawa ◽  
Fumiyoshi Yanagisawa

2016 ◽  
Vol 41 (3) ◽  
pp. 223 ◽  
Author(s):  
Shashi Kant ◽  
Anant Gupta ◽  
ChandrakantS Pandav ◽  
SanjeevK Gupta ◽  
SanjayK Rai ◽  
...  

1965 ◽  
Vol 48 (4) ◽  
pp. 609-618 ◽  
Author(s):  
H. K. Dyster-Aas ◽  
C. E. T. Krakau

ABSTRACT In addition to the previously described permeability disturbance in the blood aqueous barrier of the eye, measured as an increase of the aqueous flare, a series of transitory systemic effects have been recorded following the subcutaneous injection of synthetic α-MSH: marked increase of the free fatty acids in plasma, decrease in the serum calcium level, decrease in the blood pressure, increase in the skin temperature, increased frequency and diminished amplitude of respiration, presence of slow waves in the EEG. There is a correlation between the magnitude of the aqueous flare increase and the increase of free fatty acids in plasma and also between the aqueous flare and the minimum serum calcium level.


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