scholarly journals Association of Optimal Combination Drug Treatment with Obesity Status among Recent Ischemic Stroke Patients: Results of the Vitamin Intervention for Stroke Prevention (VISP) Trial

2017 ◽  
Vol 19 (2) ◽  
pp. 213-221 ◽  
Author(s):  
Jong-Ho Park ◽  
Juneyoung Lee ◽  
Bruce Ovbiagele
Keyword(s):  
Ischemic Stroke ◽  
Drug Treatment ◽  
Stroke Prevention ◽  
Optimal Combination ◽  
Stroke Patients ◽  
Combination Drug ◽  
Obesity Status ◽  
Combination Drug Treatment

Abstract TMP96: Optimal Combination Drug Therapy and Clinical Outcomes After Stroke by Obesity Status

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Jong-Ho Park ◽  
Bruce Ovbiagele
Keyword(s):  
Ischemic Stroke ◽  
Secondary Prevention ◽  
Clinical Outcomes ◽  
Obesity Paradox ◽  
Optimal Combination ◽  
Obese Patients ◽  
Stroke Patients ◽  
Vascular Events ◽  
Combination Drug ◽  
Obesity Status

Background: Of various explanations for the ‘obesity paradox’ that lean people with cardiovascular diseases are more likely to have poorer outcomes vs. obese, one hypothesis is that obese patients display a readily identifiable high vascular risk phenotype that may lead to receiving or seeking earlier/more aggressive treatment. Objective: To examine whether lean stroke patients are less likely to receive optimal combination treatment (OCT) and explore a differential impact of combination therapy on clinical outcomes in lean stroke patients. Methods: We analyzed a clinical trial dataset comprising 3643 recent (<120 days) ischemic stroke patients followed up for 2 years. Subjects were categorized as having lean body mass index (BMI, <25 kg/m2, n=1006), overweight BMI (25 to 29.9 kg/m2, n=1493), and obese BMI 30 <kg/m2, n=1144). Subjects were categorized by level 0 to III depending on the number of the secondary prevention prescription divided by the number of drugs potentially indicated for each patient (0=none of the indicated medications and III=all indicated medications as OCT). Independent associations of each BMI category with all-cause death and major vascular events (stroke/myocardial infarction/vascular death) were assessed. Results: All-cause death occurred in 7.3% in lean, 5.5% in overweight, and 5.1% in obese patients. Frequency of OCT (level III) was 45.8% in lean, 51.7% in overweight, and 55.3% in obese patients. Subjects with lower BMI status had lesser frequency of OCT (45.8% in lean, 51.7% in overweight, and 55.3% in obese; P<0.001). Obese (vs. lean) patients were less likely to experience death (HR 0.70; 95% CI: 0.50–0.99, P=0.034), although this decreased risk was slightly attenuated and not significant after multivariable adjustment and was not seen with major vascular events. In multivariable analyses, compared with levels 0 and I, level II and level III were linked to lower risk of major vascular events (0.55; 0.32-0.95 and 0.48; 0.28–0.83) and death (0.44; 0.21-0.96 and 0.23; 0.10–0.54) among lean patients. Conclusions: OCT of secondary prevention medication after a recent ischemic stroke is less frequent in lean (vs. obese) patients, but when implemented is related to significantly better clinical outcomes among lean patients.

Efficacy of Naproxen Plus Gabapentin Vs Naproxen Alone in Relieving Post-Extraction Pain of Impacted Mandibular 3rd Molar

2021 ◽  
Vol 15 (12) ◽  
pp. 3264-3267
Author(s):  
Safia Khatoon ◽  
Muhammad Ilyas Shaikh ◽  
Arslan Mahmood ◽  
Priya Rani Harjani ◽  
Sarang Suresh ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Drug Treatment ◽  
Rating Scale ◽  
Third Molar ◽  
Pain Scale ◽  
Combination Drug ◽  
Impacted Mandibular Third Molar ◽  
Pain Status ◽  
Mandibular Third Molar ◽  
Combination Drug Treatment

Background: Evaluate the efficacy of using combination drug treatment to relieve post extraction pain of impacted mandibular third molar by using Naproxen plus Gabapentin versus Naproxen alone. Aim: To evaluate the efficacy of using combination drug treatment to relieve post extraction pain of impacted mandibular third molar by using Naproxen plus Gabapentin versus Naproxen alone. Methods: Randomized control study, outcome was evaluated by measuring Pre – Operative and 24-Hour Post – Operative Pain status on Visual Analogue Scale and Wong Baker’s Face Pain Rating Scale. Results: Combination therapy (Naproxen and Gabapentin) was effective in significant pain reduction at 12 Hour and 24-Hour Post Extraction period. With 26 patients out 31 presented with Pain Scale of 0 on combination therapy while only 3 out of 31 for naproxen alone after 24 hours. Conclusion: Enhanced effect of combination therapy of naproxen with gabapentin in reducing post extraction pain of impacted mandibular third molar with respect to naproxen alone. Keywords: Naproxen, Gabapentin, Combination Therapy, Post Extraction Pain, Post Extraction Analgesia, Efficacy.

scholarly journals Human Norovirus Inhibition through Combination Drug Treatment

2018 ◽  
Vol 114 (3) ◽  
pp. 222a
Author(s):  
Alessa Ringel ◽  
Turgay Kilic ◽  
Jessica Devant ◽  
Kerstin Ruoff ◽  
Anna Koromyslova ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Combination Drug ◽  
Human Norovirus ◽  
Combination Drug Treatment

A Combination Drug Treatment for Acute Common Migraine

1986 ◽  
Vol 26 (5) ◽  
pp. 231-236 ◽  
Author(s):  
Eugene Uzogara ◽  
David V. Sheehan ◽  
Theo C. Manschreck ◽  
Kenneth J. Jones
Keyword(s):  
Drug Treatment ◽  
Combination Drug ◽  
Combination Drug Treatment
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