Significant suppression of premature ventricular ectopics with ivabradine in dilated cardiomyopathy

1970 ◽  
Vol 6 (1) ◽  
pp. 9-12
Author(s):  
Sajal K Banerjee ◽  
Fazlur Rahman ◽  
Mohammad Salman ◽  
Md Abu Siddique ◽  
SM Mustafa Zaman ◽  
...  

Clinicians continue to face the challenges of identifying and treating the idiopathic dilated cardiomyopathy to improve symptoms and survival. A study on idiopathic dilated cardiomyopathy was done in the Department of Cardiology, University Cardiac Center, Bangabandhu Sheikh Mujib Medical University, Dhaka, from January 2004 to December 2009. The aim of this study was to examine clinical profile of patients with idiopathic dilated cardiomyopathy. The age range was 18 to 65 years and 70% subjects were male. Most common symptom was dyspnea (86%) and cough (75%). 75% subjects had sinus tachycardia, 42% had ventricular ectopics and 40% had left bundle branch block. Mean diastolic dimension was 60±9 mm, ejection fraction was 28±8%, left atrial dimension was 40±6 mm and 36% were having mitral regurgitation. Left ventricular failure (75%) and various type of arrhythmias (62%) were the main complications. 8% subjects were died during hospital stay. Hence the clinical presentation of idiopathic dilated cardiomyopathy varies from patient to patient, but most patients present later, i.e. at some point in the spectrum of heart failure. Key words: Idiopathic dilated cardiomyopathy; left ventricular failure; ventricular ectopics. DOI: 10.3329/uhj.v6i1.7182University Heart Journal Vol.6(1) 2010 pp.9-12


Author(s):  
Xia Mingyu ◽  
Ma Wengshu ◽  
Wu Xiangh ◽  
Chen Dong

This paper describes morphological and cytochemistry changes of endomyocardial biopsy in 94 patients. The samples of myoicardium were taken from 32 patients with dilated cardiomyopathy, and sdudied with light and electron microscop. The cytochemical studies in some of these patients were performed at histological and ultrastructure level. This paper also reported the result of myocardial biopsy in 33 patients with serious dysrythmia.The result of this controlled study indicates that morphological assessment in both cardiomyopathy and congenital or rheumatic heart diseases showed no special changes. In patients of dilated cardiomyopathy, the decreased activity of myosin ATPase was secondary to cardial failure. The change of succinate dehydrogenase (SDHase) was not significant with light microscopy. But ultrastructural localization of SDHase activity is valuable. Its activity was found to be localized in endomembrane and ridge of the mitochondria, the activity of this enzyme was decrease, normal, or increase. SDHase activity was more intense in cardial myocytes well-functioning, or ultrastructurally well preserved hearts.


2006 ◽  
Vol 5 (1) ◽  
pp. 68-68
Author(s):  
K MIETTINEN ◽  
S ERIKSSON ◽  
J MAGGA ◽  
P TUOMAINEN ◽  
E VANNINEN ◽  
...  

2007 ◽  
Vol 6 (1) ◽  
pp. 28-29
Author(s):  
M DIDONATO ◽  
S CASTELVECCHIO ◽  
F FANTINI ◽  
Y BRANCOVIC ◽  
L MENICANTI

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