scholarly journals A Case of Familial Adenomatous Polyposis with Multiple Colorectal Cancers for which DWI-MRI were Useful in Preoperative Diagnosis

2008 ◽  
Vol 41 (2) ◽  
pp. 253-257
Author(s):  
Hidenori Miyamoto ◽  
Masanori Nishioka ◽  
Nobuhiro Kurita ◽  
Kouzou Yoshikawa ◽  
Jun Higashijima ◽  
...  
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Preoperative Diagnosis ◽  
Colorectal Cancers ◽  
Adenomatous Polyposis

scholarly journals Depressed-Type Colonic Lesions and “De Novo” Cancer in Familial Adenomatous Polyposis: A Colonoscopist’s Viewpoint

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Shin-ei Kudo ◽  
Yuusaku Sugihara ◽  
Hiroyuki Kida ◽  
Fumio Ishida ◽  
Hideyuki Miyachi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Familial Adenomatous Polyposis ◽  
De Novo ◽  
Early Stage ◽  
Colorectal Cancers ◽  
Adenomatous Polyposis ◽  
Depressed Type ◽  
Polyposis Syndrome ◽  
De Novo Cancer ◽  
Almost All

Familial adenomatous polyposis (FAP) is the most common inherited polyposis syndrome. Almost all patients with FAP will develop colorectal cancer if their FAP is not identified and treated at an early stage. Although there are many reports about polypoid lesions and colorectal cancers in FAP patients, little information is available concerning depressed lesions in FAP patients. Several reports suggested that depressed-type lesions are characteristic of FAP and important in the light of their rapid growth and high malignancy. Here, we describe the occurrence of depressed-type lesions in FAP patients treated at our institution. Between April 2001 and March 2010, eight of 18 FAP patients had colorectal cancers. Depressed-type colorectal cancer was found in three patients. It should be kept in mind that depressed-type lesions occur even in FAP.

The incidence of invasive colorectal cancers accompanied with adenomas in familial adenomatous polyposis

1998 ◽  
Vol 114 ◽  
pp. A685
Author(s):  
A. Takada ◽  
T. Akasu ◽  
Y. Nakanishi ◽  
T. Shimoda ◽  
S. Fujita ◽  
...  
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Colorectal Cancers ◽  
Adenomatous Polyposis

scholarly journals Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers

2004 ◽  
Vol 84 (12) ◽  
pp. 1619-1630 ◽  
Author(s):  
Sabine Colnot ◽  
Michiko Niwa-Kawakita ◽  
Ghislaine Hamard ◽  
Cécile Godard ◽  
Servane Le Plenier ◽  
...  
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Mouse Model ◽  
Colorectal Cancers ◽  
Adenomatous Polyposis

scholarly journals Conversion Therapy Using mFOLFOX6 With Panitumumab for Unresectable Liver Metastases From Multiple Colorectal Cancers With Familial Adenomatous Polyposis

2014 ◽  
Vol 99 (6) ◽  
pp. 795-801 ◽  
Author(s):  
Yuji Toiyama ◽  
Yasuhiro Inoue ◽  
Takahito Kitajima ◽  
Masato Okigami ◽  
Mikio Kawamura ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Colon Cancer ◽  
Familial Adenomatous Polyposis ◽  
Liver Metastases ◽  
Sigmoid Colon ◽  
Immunohistochemical Analysis ◽  
Sigmoid Colon Cancer ◽  
Colorectal Cancers ◽  
Adenomatous Polyposis ◽  
Wild Type

Abstract A 39-year-old man received a diagnosis of unresectable multiple liver metastases from multiple colorectal cancers with familial adenomatous polyposis. After construction of an ileostomy, modified FOLFOX6 (mFOLFOX6) with panitumumab was administrated because rectal cancer and sigmoid colon cancer are KRAS wild type. The 13 courses of chemotherapy resulted in a marked reduction in the size of liver metastases and sigmoid colon cancer. Consequently, curative resection with total colectomy, ileal pouch anal anastomosis, and liver metastasis resection with radiofrequency ablation was performed. Progression of KRAS wild-type rectal cancer after chemotherapy suggested that each clone from rectal and sigmoid colon cancer might have a different sensitivity to epidermal growth factor receptor antibody. Immunohistochemical analysis revealed loss of PTEN expression in rectal cancer compared with liver metastases from sigmoid colon cancer, showing that the difference of mFOLFOX6 with panitumumab might be related to activation of the PI3K-AKT pathway.

A Case of Familial Adenomatous Polyposis in a Teenager

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 418A-418A
Author(s):  
Mariecel Pilapil ◽  
Toni Webster ◽  
Steven ◽  
Alexandra Cohen ◽  
Ravi Sharaf
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Adenomatous Polyposis
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