scholarly journals Identification of Angiopoietin-2 as a Novel Angiogenic Switch Molecule of Hepatocellular Carcinoma and Its Signal Inhibitor for Tumor Dormancy Therapy.

2001 ◽  
Vol 34 (4) ◽  
pp. 415-419
Author(s):  
Shinji Tanaka ◽  
Keishi Sugimachi ◽  
Yo-ichi Yamashita ◽  
Mitsuo Shimada ◽  
Keizo Sugimachi
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Dormancy ◽  
Angiogenic Switch ◽  
Tumor Dormancy Therapy ◽  
Angiopoietin 2

Tumor Dormancy and the Angiogenic Switch: Possible Implications of Bone Marrow- Derived Cells

2014 ◽  
Vol 20 (30) ◽  
pp. 4920-4933 ◽  
Author(s):  
Yuval Shaked ◽  
Sandra McAllister ◽  
Ofer Fainaru ◽  
Nava Almog
Keyword(s):  
Bone Marrow ◽  
Tumor Dormancy ◽  
Angiogenic Switch ◽  
Bone Marrow Derived Cells

scholarly journals Role of Tie2, CD14, Angiopoietin as Angiogenetic Markers in Hepatocellular Carcinoma Complicating Hepatitis C Virus Infection

2019 ◽  
Vol 3 (2) ◽  
pp. 23-34
Author(s):  
El-Zahraa M. Meghezel ◽  
Heba A. Ahmed ◽  
Ashraf A Askar ◽  
Emad Eldin Nabil ◽  
Ashraf Elyamany
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C ◽  
High Risk Group ◽  
P Value ◽  
Group Iii ◽  
Group I ◽  
Angiopoietin 2 ◽  
Chronic Hepatitis C Patients ◽  
Potential Use

Background Identifying biomarkers for early detection of hepatocellular carcinoma (HCC) remains quite challenging. In this study we aimed to estimate the number of TIE2-expressing monocytes (TEMs) cells, which display pro-tumoral activities and are defined as CD14+, TIE2+, and angiopoietin-2; and its potential use as a possible diagnostic marker in HCC patients complicating HCV induced cirrhosis. Methods Current study was conducted on 112 patients. They were divided into two groups: Group I (78 patients) with HCC complicating HCV induced cirrhosis; and group II chronic hepatitis C patients (34 patients). Both groups were compared to (age and sex-matched) healthy persons as group III (38 persons). Result The number of the circulating TEMs: CD14+ and TIE2+ monocytes were significantly higher in the peripheral blood of HCC patients than HCV LC patients and healthy controls, sensitivity and specificity for HCC diagnosis were respectively: CD14 (89.7%, 83.3%), TIE 2 (76.9%, 83.3%), and Ang-2 (76.9%, 66.7%). Moreover, analysis of the P-value and the odd’s ratio showed that CD14 has the highest predictive value for HCC. Conclusion Our results suggest that TEMs and Ang-2can be used as diagnostic markers for HCC, especially among the high-risk group of patients.

scholarly journals Significance of Thermo-Chemotherapy as a Tumor Dormancy Therapy for Unresectable or Recurrent Gastrointestinal Malignancy.

2001 ◽  
Vol 34 (4) ◽  
pp. 403-408
Author(s):  
Satoru Miyazaki ◽  
Masayasu Hamaji ◽  
Masaaki Izukura ◽  
Junichi Nishijima ◽  
Kunihiko Oku ◽  
...  
Keyword(s):  
Tumor Dormancy ◽  
Gastrointestinal Malignancy ◽  
Tumor Dormancy Therapy

Angiopoietin-2 Serum Levels Are Elevated in Patients With Liver Cirrhosis and Hepatocellular Carcinoma

2007 ◽  
Vol 102 (11) ◽  
pp. 2471-2481 ◽  
Author(s):  
Arne Scholz ◽  
Vanessa Annina Rehm ◽  
Svenja Rieke ◽  
Katja Derkow ◽  
Petra Schulz ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Serum Levels ◽  
Angiopoietin 2

scholarly journals An Experimental Model of Tumor Dormancy Therapy for Advanced Head and Neck Carcinoma

2000 ◽  
Vol 91 (11) ◽  
pp. 1199-1203 ◽  
Author(s):  
Goshi Nishimura ◽  
Shunsuke Yanoma ◽  
Kenichi Satake ◽  
Yoichi Ikeda ◽  
Takahide Taguchi ◽  
...  
Keyword(s):  
Head And Neck ◽  
Experimental Model ◽  
Head And Neck Carcinoma ◽  
Tumor Dormancy ◽  
Advanced Head ◽  
Neck Carcinoma ◽  
Tumor Dormancy Therapy

scholarly journals ANGPT2 and NOS3 Polymorphisms and Clinical Outcome in Advanced Hepatocellular Carcinoma Patients Receiving Sorafenib

Cancers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1023 ◽  
Author(s):  
Giorgia Marisi ◽  
Elisabetta Petracci ◽  
Francesco Raimondi ◽  
Luca Faloppi ◽  
Francesco Giuseppe Foschi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Direct Sequencing ◽  
Univariate Analysis ◽  
Progression Free Survival ◽  
Standard Of Care ◽  
Advanced Hepatocellular Carcinoma ◽  
Nucleotide Polymorphisms ◽  
Number Of Patients ◽  
Angiopoietin 2 ◽  
Oxide Synthase

Sorafenib represents the standard of care for advanced hepatocellular carcinoma (HCC), even though a large number of patients have reported limited efficacy. The aim of the present study was to evaluate the prognostic value of single-nucleotide polymorphisms on angiopoietin-2 (ANGPT2) and endothelial-derived nitric oxide synthase (NOS3) genes in 135 patients with advanced HCC receiving sorafenib. Eight ANGPT2 polymorphisms were analyzed by direct sequencing in relation to overall survival (OS) and progression-free survival (PFS). In univariate analysis, ANGPT2rs55633437 and NOS3 rs2070744 were associated with OS and PFS. In particular, patients with ANGPT2rs55633437 TT/GT genotypes had significantly lower median OS (4.66 vs. 15.5 months, hazard ratio (HR) 4.86, 95% CI 2.73–8.67, p < 0.001) and PFS (1.58 vs. 6.27 months, HR 4.79, 95% CI 2.73–8.35, p < 0.001) than those homozygous for the G allele. Moreover, patients with NOS3 rs2070744 TC/CC genotypes had significantly higher median OS (15.6 vs. 9.1 months, HR 0.65, 95% CI 0.44–0.97; p = 0.036) and PFS (7.03 vs. 3.5 months, HR 0.43, 95% CI 0.30–0.63; p < 0.001) than patients homozygous for the T allele. Multivariate analysis confirmed these polymorphisms as independent prognostic factors. Our results suggest that ANGPT2rs55633437 and NOS3 rs2070744 polymorphisms could identify a subset of HCC patients more resistant to sorafenib.

TS-1 as single chemotherapy for elderly head and neck cancer patients-Feasibility of tumor dormancy therapy-

Toukeibu Gan ◽  
2007 ◽  
Vol 33 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Kenji Okami ◽  
Takahide Hamano ◽  
Teruhisa Takeo ◽  
Motoki Sekine ◽  
Ryoko Wada ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Tumor Dormancy ◽  
Tumor Dormancy Therapy

Serum angiopoietin-2 level as a predictor of tumor invasiveness in patients with hepatocellular carcinoma

2012 ◽  
Vol 48 (3) ◽  
pp. 334-343 ◽  
Author(s):  
Antonio Diaz-Sanchez ◽  
Ana Matilla ◽  
Oscar Nuñez ◽  
Raquel Lorente ◽  
Alejandro Fernandez ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Invasiveness ◽  
Angiopoietin 2
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