scholarly journals Can empirical hypertonic saline or sodium bicarbonate treatment prevent the development of cardiotoxicity during serious amitriptyline poisoning? Experimental research: cardiovascular topic

2015 ◽  
Vol 26 (3) ◽  
pp. 134-139 ◽  
Author(s):  
MS Paksu ◽  
H Zengin ◽  
F Ilkaya ◽  
S Paksu ◽  
H Guzel ◽  
...  
Keyword(s):  
Sodium Bicarbonate ◽  
Hypertonic Saline ◽  
Experimental Research ◽  
Amitriptyline Poisoning

A1227 HEMODYNAMIC AND METABOLIC EFFECTS OF SODIUM BICARBONATE, CARBICARB AND HYPERTONIC SALINE IN LACTIC ACIDOSIS

1990 ◽  
Vol 73 (3A) ◽  
pp. NA-NA
Author(s):  
E. Benjamin ◽  
J. K. Wang ◽  
A. Abalos ◽  
A. Klapholz ◽  
J. Oropello ◽  
...  
Keyword(s):  
Lactic Acidosis ◽  
Sodium Bicarbonate ◽  
Hypertonic Saline ◽  
Metabolic Effects

The cardiovascular effects of hypertonic sodium bicarbonate in conscious dogs: underlying mechanisms of action

1984 ◽  
Vol 62 (3) ◽  
pp. 314-318 ◽  
Author(s):  
Louis Dumont ◽  
Paul Stanley ◽  
Claude Chartrand
Keyword(s):  
Sodium Bicarbonate ◽  
Left Atrium ◽  
Hypertonic Saline ◽  
Peripheral Resistance ◽  
Conscious Dogs ◽  
Right Atrial ◽  
Bolus Administration ◽  
Stroke Work ◽  
Myocardial Depression ◽  
Acid Base

Mechanisms underlying the transient hypotensive effect (central or peripheral) of rapid bolus administration of hypertonic sodium bicarbonate (NaHCO3) were studied in conscious dogs. Thirteen animals equipped with an electromagnetic flow probe positioned around the ascending aorta were utilized. NaHCO3 (18.5 mequiv. of 1786 mosmol/L), hypertonic saline solution having the same sodium concentration as NaHCO3, and mannitol solution with the same osmolarity as NaHCO3, were injected in the right and in the left atrium. Intra-arterial NaHCO3 was tested to assess its direct peripheral vascular effects. Blood ionic as well as acid–base modifications following NaHCO3 were also studied. Our results indicate that right atrial injection of NaHCO3 elicited transient hypotension (−10 to −15 mmHg (1 mmHg = 133.322 Pa)) and myocardial depression as revealed by a significant decrease of stroke volume (−8%), stroke power (−18%), stroke work (−12%), maximum systolic flow (−13%), peak velocity (−13%), and maximum acceleration (−24%). When the solution is injected in the left atrium, myocardial depression is more pronounced suggesting that the coronary bed is the site of action. Hypertonic saline injections indicate that the sodium load plays a role in this decrement of myocardial function while hyperosmolarity per se, as exemplified with mannitol injections, elicits no negative effect. Transient ionic as well as acid–base disturbances are other mechanisms that have to be considered along with coronary vasoconstriction. Decrement in peripheral resistance appears only with right intra-atrial NaHCO3 suggesting that the pulmonary vascular bed is the origin of this reflex.

Intranasal instillation of distilled water, hypertonic saline and sodium bicarbonate promotes redox imbalance and acute lung inflammation in adult mice

2019 ◽  
Vol 266 ◽  
pp. 27-32 ◽  
Author(s):  
Sophia Dias Pozzolini Fróes ◽  
Ana Beatriz Farias de Souza ◽  
Natália Alves de Matos ◽  
Nicole Elizabeth Philips ◽  
Guilherme de Paula Costa ◽  
...  
Keyword(s):  
Sodium Bicarbonate ◽  
Hypertonic Saline ◽  
Lung Inflammation ◽  
Distilled Water ◽  
Acute Lung Inflammation ◽  
Redox Imbalance ◽  
Adult Mice ◽  
Intranasal Instillation

SODIUM BICARBONATE OR HYPERTONIC SALINE IMPROVES OUTCOME OF HYPOXIC ACIDOSIS

1989 ◽  
Vol 71 (Supplement) ◽  
pp. A1013
Author(s):  
Ann E. Thompson ◽  
Bradley P. Fuhrman ◽  
Donna F. Howlarid ◽  
Maria DeFrancisis
Keyword(s):  
Sodium Bicarbonate ◽  
Hypertonic Saline

Ultrastructure of the basal body apparatus in epidermal cells of a sponge larva (Aplysilla SP: Demospongiae)

1992 ◽  
Vol 50 (1) ◽  
pp. 928-929
Author(s):  
R.L. Pinto ◽  
R.M. Woollacott
Keyword(s):  
Sodium Bicarbonate ◽  
Epoxy Resin ◽  
Basal Body ◽  
Phosphate Buffer ◽  
Similar Data ◽  
Basal Apparatus ◽  
Striated Rootlet ◽  
The Common ◽  
Basal Foot ◽  
Sexually Mature

The basal body and its associated rootlet are the organelles responsible for anchoring the flagellum or cilium in the cytoplasm. Structurally, the common denominators of the basal apparatus are the basal body, a basal foot from which microtubules or microfilaments emanate, and a striated rootlet. A study of the basal apparatus from cells of the epidermis of a sponge larva was initiated to provide a comparison with similar data on adult sponges.Sexually mature colonies of Aplysillasp were collected from Keehi Lagoon Marina, Honolulu, Hawaii. Larvae were fixed in 2.5% glutaraldehyde and 0.14 M NaCl in 0.2 M Millonig’s phosphate buffer (pH 7.4). Specimens were postfixed in 1% OsO4 in 1.25% sodium bicarbonate (pH 7.2) and embedded in epoxy resin. The larva ofAplysilla sp was previously described (as Dendrilla cactus) based on live observations and SEM by Woollacott and Hadfield.

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