scholarly journals Benign dermoscopic parallel ridge pattern in plantar hyperpigmentation due to capecitabine

2015 ◽  
pp. 79-81
Author(s):  
Linda Tognetti ◽  
Michele Fimiani ◽  
Pietro Rubegni
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Outpatient Clinic ◽  
Recurrent Breast Cancer ◽  
Eccrine Gland ◽  
Drug Induced ◽  
The Past ◽  
Ridge Pattern ◽  
History Of ◽  
Recurrent Breast

We report the case of a 37-year-old woman (phototype II) who presented at our outpatient clinic with a two-month history of hyperpigmented plantar macules. Medical history revealed that the patient had taken capecitabine in the past three months as adjuvant chemotherapy for recurrent breast cancer. Dermoscopic examination of the plantar macules showed parallel ridge pattern with pigmentation in the furrows without obliteration of eccrine gland apertures. Besides in acral melanoma, parallel ridge pattern can also be observed in benign plantar lesions, such as congenital or acquired acral nevi, subcorneal hemorrhage, dye-related pigmentation and drug-induced hyperpigmentation, especially in patients with phototypes III-VI. The few reported cases of capecitabine-induced hyperpigmentation have been associated with hand and foot syndrome in patients with phototypes IV-V and palmar as well as plantar involvement.

Postchemotherapy rheumatism.

1993 ◽  
Vol 11 (4) ◽  
pp. 768-770 ◽  
Author(s):  
C L Loprinzi ◽  
J Duffy ◽  
J N Ingle
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Combination Chemotherapy ◽  
Case Reports ◽  
Cancer Recurrence ◽  
Recurrent Breast Cancer ◽  
Rheumatologic Diseases ◽  
Clinical Phenomenon ◽  
Recurrent Breast

PURPOSE This report describes a previously unreported clinical phenomenon that occurs in some patients after completion of combination chemotherapy. METHODS AND RESULTS Eight case reports are presented. Affected patients developed a syndrome of myalgias/arthralgias within several months of completing cyclophosphamide/fluorouracil (5FU)-containing adjuvant combination chemotherapy for breast cancer. These symptoms did not appear to be related to cancer recurrence or any common rheumatologic disorder. The syndrome generally resolved over several months. CONCLUSION Postchemotherapy rheumatism is a syndrome of myalgias/arthralgias that usually develops 1 to 3 months after completion of adjuvant chemotherapy. Recognition of this syndrome can limit the need for extensive work-ups to exclude recurrent breast cancer or inflammatory rheumatologic diseases.

scholarly journals Assessment of predictors and prognostic factors for locoregional recurrent breast cancer

2018 ◽  
Vol 6 (1) ◽  
pp. 287
Author(s):  
Hossam A. Elfol ◽  
Tarek M. Rageh ◽  
Mohammed A. Hamed
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Safety Margin ◽  
Radical Mastectomy ◽  
Recurrent Breast Cancer ◽  
Oral Contraceptive Pills ◽  
Female Patients ◽  
History Of ◽  
Recurrent Breast ◽  
Locoregional Recurrent Breast Cancer

Background: Assessment of predictors and prognostic factors of locoregional recurrent breast cancer will help in management of those patients. The aim of this study was to assess and identify the predictors and prognostic factors for locoregional current breast cancer.Methods: This prospective study will be carried out on 50 female patients with history of breast cancer underwent surgical procedures either modified radical mastectomy (MRM) or conservative breast surgery (CBS) and adjuvant therapy (chemotherapy, radiotherapy, hormonal therapy).Results: Significant relationship between recurrence of breast cancer and Oral contraceptive pills of the studied female patients with history of breast cancer underwent surgery.Conclusions: Number of positive lymph nodes, lympho-vascular invasion, positive safety margin and presence of extensive intra-ductal component all these factors increase risk of recurrent breast cancer.

Delineation of an unknown significance FANCA genetic variant in a recurrent breast cancer patient

2021 ◽  
Vol 14 (3) ◽  
pp. e241251
Author(s):  
Stavroula Kastora ◽  
Olga Triantafyllidou ◽  
Georgios Kounidas ◽  
Nikolaos Vlahos
Keyword(s):  
Breast Cancer ◽  
Bilateral Breast Cancer ◽  
Recurrent Breast Cancer ◽  
Complementation Group ◽  
Fanconi Anaemia ◽  
Unknown Significance ◽  
History Of ◽  
Common Clinical Practice ◽  
Recurrent Breast

Fanconi anaemia is a heterogeneous condition associated with mutations in the Fanconi anaemia complementation group (FANC). The FANC group has also been extensively associated with tumourigenesis due to its intricate association with the cellular repair mechanism. In this case report, we are drawing initial associations between a previously unreported FANC-A gene point mutation (P1222L) and familial breast cancer, by examining the presentation and management of a 65-year-old female patient with history of bilateral breast cancer of two different histological categories (ductal and in situ lobular). Here, we present a further genetic analysis beyond the common clinical practice to understand the patient’s genetic predisposition and improve their long-term management.

Possible adverse effect of failed adjuvant chemotherapy on the prognosis of women receiving consecutive chemotherapy for recurrent breast cancer

1987 ◽  
Vol 113 (5) ◽  
pp. 488-494 ◽  
Author(s):  
Christian Dittrich ◽  
Raimund Jakesz ◽  
Klaus Pirich ◽  
Lieselotte Havelec ◽  
G�nther Steger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adverse Effect ◽  
Adjuvant Chemotherapy ◽  
Recurrent Breast Cancer ◽  
Recurrent Breast

Image-guided biopsy in women with breast cancer presenting with peritoneal carcinomatosis

2006 ◽  
Vol 16 (Suppl 1) ◽  
pp. 108-110 ◽  
Author(s):  
M. J. Hewitt ◽  
G. D. Hall ◽  
N. Wilkinson ◽  
T. J. Perren ◽  
G. Lane ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Peritoneal Carcinomatosis ◽  
Exploratory Laparotomy ◽  
Recurrent Breast Cancer ◽  
Second Primary ◽  
Primary Tumors ◽  
Image Guided ◽  
History Of ◽  
Clinical Dilemma ◽  
Recurrent Breast

When women with a history of breast cancer present with peritoneal carcinomatosis, the differential diagnosis lies between recurrent breast cancer or a new primary tumor. This scenario is of particular relevance to women with a BRCA gene mutation, who have a genetic predisposition to develop second primary tumors of the ovary, fallopian tube, and peritoneum. We describe the use of image-guided core biopsy as an alternative to laparoscopy or exploratory laparotomy in providing minimally invasive diagnosis in this increasingly common clinical dilemma.

scholarly journals Survival in patients with metastatic recurrent breast cancer after adjuvant chemotherapy

Cancer ◽  
2012 ◽  
Vol 119 (6) ◽  
pp. 1140-1148 ◽  
Author(s):  
Amye J. Tevaarwerk ◽  
Robert J. Gray ◽  
Bryan P. Schneider ◽  
Mary Lou Smith ◽  
Lynne I. Wagner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Recurrent Breast Cancer ◽  
Recurrent Breast

scholarly journals MRI surveillance for women with a personal history of breast cancer: comparison between abbreviated and full diagnostic protocol

2020 ◽  
Vol 93 (1106) ◽  
pp. 20190733 ◽  
Author(s):  
Ko Woon Park ◽  
Sol Bee Han ◽  
Boo-Kyung Han ◽  
Eun Sook Ko ◽  
Ji Soo Choi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
Diagnostic Performance ◽  
Area Under The Curve ◽  
Breast Mri ◽  
Recurrent Breast Cancer ◽  
Personal History ◽  
History Of ◽  
Recurrent Breast

Objective: To compare the diagnostic performance of breast MRI with abbreviated protocol (AB-MRI) and full ddiagnostic protocol (FDP-MRI) for surveillance of females with a personal history of breast cancer Methods: In this retrospective study, we analyzed the outcomes of total 1312 post-operative screening breast MRI matched from 1045 AB-MRI and 677 FDP-MRI, which had histologic confirmation for suspicious MRI findings or 1 year negative follow-up images. This study was approved by the institutional review board and informed patient consent was waved. AB-MRI consists of T2 weighted scanning and dynamic contrast-enhanced imaging including one pre-contrast and two post-contrast scans. We compared the diagnostic performance for recurrent breast cancer in terms of sensitivity, specificity, positive-predictive value, negative-predictive value, and accuracy and area under the curve between the screening AB-MRI and FDP-MRI. Results: Overall, 13 recurrent tumors among 1312 post-operative cases screened with breast MRI (1.0%) were detected including 8 invasive cancer, 2 cases of in situ cancer, and 3 cases of metastatic lymph nodes. The sensitivity and negative predictive value were 70 vs 100 and 99.5% vs 100% in AB-MRI and FDP-MRI. Specificity, positive predictive value, accuracy, and area under the curve of AB-MRI and FDP-MRI were 98.0% vs 96.9%, 35.0% vs 23.1%, 97.6% vs 97.0%, and 0.840 vs 0.985, respectively. Conclusion: The performance of AB-MRI was comparable to that of FDP-MRI in detecting recurrent breast cancer and decreased false positive cases. Advances in knowledge: AB-MRI provides a reliable alternative with similar diagnostic performance and shorter MRI acquisition time.

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