Bone marrow mesenchymal stem cell applications in treatment of traumatic brain injury following intraperitoneal Silymarin injection in a rat model

2015 ◽  
Vol 20 (Special Issue) ◽  
Author(s):  
Ayoob Rostamzadeh ◽  
Reza Ahmadi ◽  
Mohammad Farzizadeh
Keyword(s):  
Traumatic Brain Injury ◽  
Bone Marrow ◽  
Stem Cell ◽  
Brain Injury ◽  
Mesenchymal Stem Cell ◽  
Rat Model

Use of human mesenchymal stem cell treatment to prevent anhedonia in a rat model of traumatic brain injury

2016 ◽  
Vol 34 (3) ◽  
pp. 433-441 ◽  
Author(s):  
Ali Darkazalli ◽  
Abdol Aziz Ould Ismail ◽  
Nastaren Abad ◽  
Samuel C. Grant ◽  
Cathy W. Levenson
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cell ◽  
Brain Injury ◽  
Mesenchymal Stem Cell ◽  
Rat Model ◽  
Human Mesenchymal Stem Cell ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

scholarly journals Mesenchymal Stem Cell–Derived Exosomes Improve Functional Recovery in Rats After Traumatic Brain Injury: A Dose-Response and Therapeutic Window Study

2020 ◽  
Vol 34 (7) ◽  
pp. 616-626 ◽  
Author(s):  
Yanlu Zhang ◽  
Yi Zhang ◽  
Michael Chopp ◽  
Zheng Gang Zhang ◽  
Asim Mahmood ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cell ◽  
Brain Injury ◽  
Mesenchymal Stem Cell ◽  
Intravenous Injection ◽  
Dose Response ◽  
Time Dependent ◽  
Male Rats ◽  
Therapeutic Window ◽  
Single Intravenous Injection

Background. Mesenchymal stem cell (MSC)-derived exosomes play a critical role in regenerative medicine. Objective. To determine the dose- and time-dependent efficacy of exosomes for treatment of traumatic brain injury (TBI). Methods. Male rats were subjected to a unilateral moderate cortical contusion. In the dose-response study, animals received a single intravenous injection of exosomes (50, 100, 200 µg per rat) or vehicle, with treatment initiated at 1 day after injury. In the therapeutic window study, animals received a single intravenous injection of 100 µg exosomes or vehicle starting at 1, 4, or 7 days after injury. Neurological functional tests were performed weekly after TBI for 5 weeks. Spatial learning was measured on days 31 to 35 after TBI using the Morris water maze test. Results. Compared with the vehicle, regardless of the dose and delay in treatment, exosome treatment significantly improved sensorimotor and cognitive function, reduced hippocampal neuronal cell loss, promoted angiogenesis and neurogenesis, and reduced neuroinflammation. Exosome treatment at 100 µg per rat exhibited a significant therapeutic effect compared with the 50- or 200-µg exosome groups. The time-dependent exosome treatment data demonstrated that exosome treatment starting at 1 day post-TBI provided a significantly greater improvement in functional and histological outcomes than exosome treatments at the other 2 delayed treatments. Conclusions. These results indicate that exosomes have a wide range of effective doses for treatment of TBI with a therapeutic window of at least 7 days postinjury. Exosomes may provide a novel therapeutic intervention in TBI.

scholarly journals The Role of Mesenchymal Stem Cell Therapy in Traumatic Brain Injury: A Review from Basic Research to Clinical Challenges

BioMedica ◽  
2021 ◽  
Vol 37 (3) ◽  
pp. 1-19
Author(s):  
Cui Lianxu ◽  
Yasmeen Saeed ◽  
Li Haomin ◽  
Yang Jingli
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cell ◽  
Brain Injury ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Basic Research ◽  
Treatment Modalities ◽  
Mesenchymal Stem Cell Therapy

<p>Traumatic brain injury (TBI) is a focal injury with limited reliable treatment options. Despite the large volume of basic research into TBI (particularly on the complex pathophysiology and on the application of various techniques), the treatment of TBI currently remains a challenge due to the low efficacy of available therapeutic options. Recent studies have shown that stem cells possess the ability to aid in recovery from the damaging effects of the craniocerebral injury. Herein, we attempted to present a generalized critique for the role of mesenchymal stem cell therapy in TBI, its underlying mechanisms, and the scope for improvements in TBI treatment identified through preclinical studies, clinical studies, and other research in the light of previously reported literature. Finally, we summarized some novel strategies to overcome the clinical challenges in TBI recovery. Collectively, the major objective of this review is to highlight the to-date available findings regarding role of stem cell therapy in TBI and pave the way for the development of safe and efficient regenerative treatment modalities for TBI by comprehensive understanding the specific mechanism.</p>

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