scholarly journals Serum Cystatin C as a Marker of Renal Function in Critically Ill Patients With Normal Serum Creatinine

2014 ◽  
Vol 6 (2) ◽  
Author(s):  
Mohammad Mahdi Sagheb ◽  
Soha Namazi ◽  
Bita Geramizadeh ◽  
Amin Karimzadeh ◽  
Mohammad Bagher Oghazian ◽  
...  
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Critically Ill ◽  
Cystatin C ◽  
Critically Ill Patients ◽  
Normal Serum ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Normal Serum Creatinine

Serum cystatin C level is a good prognostic marker in patients with cirrhotic ascites and normal serum creatinine levels

2009 ◽  
Vol 29 (10) ◽  
pp. 1521-1527 ◽  
Author(s):  
Yeon Seok Seo ◽  
Eun Suk Jung ◽  
Hyonggin An ◽  
Jeong Han Kim ◽  
Young Kul Jung ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Prognostic Marker ◽  
Cystatin C ◽  
Normal Serum ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Normal Serum Creatinine

scholarly journals Assessment of renal function in recently admitted critically ill patients with normal serum creatinine

2005 ◽  
Vol 20 (4) ◽  
pp. 747-753 ◽  
Author(s):  
E. A. J. Hoste ◽  
J. Damen ◽  
R. C. Vanholder ◽  
N. H. Lameire ◽  
J. R. Delanghe ◽  
...  
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Normal Serum ◽  
Normal Serum Creatinine

scholarly journals Estimated Glomerular Filtration Rate Correlates Poorly with Four-Hour Creatinine Clearance in Critically Ill Patients with Acute Kidney Injury

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Christopher J. Kirwan ◽  
Barbara J. Philips ◽  
Iain A. M. MacPhee
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Critically Ill ◽  
Cystatin C ◽  
Critically Ill Patients ◽  
Filtration Rate ◽  
Kidney Injury ◽  
Serum Cystatin C ◽  
Serum Cystatin

Introduction.RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is needed, and some published data suggest that equations based on serum creatinine that estimate glomerular filtration rate (eGFR) can provide this. In addition, incorporating serum cystatin C concentration into estimates of GFR may improve their accuracy, but no eGFR equations are validated in critically ill patients with AKI.Aim.This study tests whether creatinine or cystatin-C-based eGFR equations, used in patients with CKD, offer an accurate representation of 4-hour creatinine clearance (4CrCl) in critically ill patients with AKI.Methods.Fifty-one critically ill patients with AKI were recruited. Thirty-seven met inclusion criteria, and the performance of eGFR equations was compared to 4CrCl.Results.eGFR equations were better than creatinine alone at predicting 4CrCl. Adding cystatin C to estimates did not improve the bias or add accuracy. The MDRD 7 eGFR had the best combination of correlation, bias, percentage error and accuracy. None were near acceptable standards quoted in patients with chronic kidney disease (CKD).Conclusions.eGFR equations are not sufficiently accurate for use in critically ill patients with AKI. Incorporating serum cystatin C does not improve estimates. eGFR should not be used to describe renal function in patients with AKI. Standards of accuracy for validating eGFR need to be set.

scholarly journals Serum Cystatin C Is Related to Pulse Wave Velocity Even in Subjects with Normal Serum Creatinine

2008 ◽  
Vol 31 (10) ◽  
pp. 1895-1902 ◽  
Author(s):  
Sang Heon Song ◽  
Ihm Soo Kwak ◽  
Young Joo Kim ◽  
Hee Sun Lee ◽  
Harin Rhee ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Serum Creatinine ◽  
Wave Velocity ◽  
Cystatin C ◽  
Pulse Wave ◽  
Normal Serum ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Normal Serum Creatinine

scholarly journals Measurement of renal function in kidney donors using serum cystatin C and β2-microglobulin

2003 ◽  
Vol 40 (6) ◽  
pp. 656-658 ◽  
Author(s):  
George T John ◽  
Jude Joseph Fleming ◽  
Girish S Talaulikar ◽  
R Selvakumar ◽  
Paaulose P Thomas ◽  
...  
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Critical Value ◽  
Critical Values ◽  
Published Data ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Kidney Donors ◽  
Reduced Renal Function

Background: The usefulness of serum cystatin C and serum β2-microglobulin (B2M) as markers of glomerular filtration rate (GFR) were compared in kidney donors before and after nephrectomy. Methods: Blood samples were taken from 28 donors (15 women and 13 men) for serum creatinine, urea, cystatin C and B2M estimation a median of 7 days before and 10 days after nephrectomy. Results: Estimated GFR decreased from a median of 86.2 mL/min/1.73 m2 to 60.3 mL/min/1.73 m2, a median decrease of 28.6%. Serum creatinine increased by 40% and urea by 30.4%; serum cystatin C increased by 31.2% and serum B2M increased by 65.6%. Using published data on biological variation, critical values were calculated. An increase in serum creatinine above 18 µmol/L detected the decline in renal function in 26/28 (92.9%) subjects. Increases in serum B2M greater than a critical value of 0.94 mg/L detected 24/28 (85.7%) of these subjects, but the critical value of 0.59 mg/L for cystatin C detected only 8/28 (28.6%). Conclusion: Using critical values, serial measurement of serum creatinine was better than serum B2M in detecting reduced renal function. Because of its large intraindividual variation, serial serum cystatin C estimation was very poor in detecting reduced renal function.

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