scholarly journals Effect of Cool Dialysate on Depression in Patients with Chronic Renal Failure Treated with Hemodialysis: A Randomized Clinical Trial

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Maryam Farhadi ◽  
Zahra Mirhosseini ◽  
Sedigheh Rastaghi ◽  
Mostafa Rad
Keyword(s):  
Clinical Trial ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Hemodialysis Patients ◽  
Depression Severity ◽  
Control Groups ◽  
P Values ◽  
Severity Of Depression ◽  
The Mean ◽  
And Control

Background: Depression is one of the most common psychiatric problems in hemodialysis patients. Objectives: This study aimed to evaluate the effect of cool dialysate on depression in patients with chronic renal failure treated with hemodialysis. Methods: This randomized clinical trial was performed on 66 hemodialysis patients suffering from depression. Patients were selected by a convenience sampling method and divided equally into intervention and control groups randomly by permuted block allocation, each group containing 33 patients. Data were acquired with the Beck Depression inventory-I. The intervention and control groups underwent one month of treatment with cool dialysate at 35.5 and 37°C, respectively. The severity of depression for each group was measured at the end of each treatment stage and two weeks after the intervention. Data were analyzed using R version 25 software with a confidence level of 95%. Results: There was no statistically significant difference between the control and intervention groups before and after the intervention (P-values more than 0.05). While the mean of depression severity for the control group decreased from 26.15 ± 1.46 to 22.24 ± 2.00 (P-values < 0.01), the mean of depression severity for the intervention group decreased from 25.56 ± 1.28 to 22.41 ± 1.65 by the intervention (P-value > 0.05). Conclusions: The application of cool dialysate as a non-pharmacological method did not significantly reduce the severity of depression in patients undergoing hemodialysis. Therefore, it is advised to perform further studies that include more research units from different geographical locations, considering a longer intervening duration.

scholarly journals Effectiveness of a Need-Based Program in Relieving Psychological Distress of Family Caregivers of Leukemia Patients: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Mehrdad Abdullahzadeh ◽  
Narjes Khosravi
Keyword(s):  
Clinical Trial ◽  
Psychological Distress ◽  
Family Caregivers ◽  
Psychological Needs ◽  
Anxiety And Depression ◽  
Study Group ◽  
Control Groups ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Abstract PurposeThe family of leukemia patients, due to their caring role, often feel psychological distress. This paper describes the efficacy of a designed family-need-based program on relieving depression, anxiety, and stress of family caregivers of leukemia patients by meeting the specific psychological needs of caregivers.MethodsIn this clinical trial, 64 family caregivers of leukemia patients referring to a medical center in Iran were recruited by convenience sampling and divided into study and control groups randomly. The study group attended a designed need-based program. The control group did not receive the intervention. Stress, anxiety, and depression before, right after, and one month after the intervention in family caregivers were compared using DASS-42. Data were analyzed using descriptive and inferential statistics; the significance level adopted was 5%.ResultsBefore the intervention, the mean score of depression, anxiety, and stress scale in both study and control groups showed no considerable difference (P > 0.05). After the intervention, the mean score of DASS-42 revealed a significant difference between the two groups and the study group did better on outcomes (P < 0.001).ConclusionThis family-need-based program can decrease the level of stress, anxiety, and depression of the family caregivers of leukemia patients and may potentially alleviate the psychological distress of family caregivers over their caring role.Trial registration number: IRCT2013093011895N2. Date of registration: 2014-05-06

scholarly journals The effect of delivery ball and warm shower on the childbirth experience of nulliparous women: A randomized controlled clinical trial

2021 ◽  
Author(s):  
parvaneh sharifipour ◽  
Masoomeh Kheirkhah ◽  
Mojgan Rajati ◽  
hamid haghani
Keyword(s):  
Clinical Trial ◽  
Pregnant Women ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Control Groups ◽  
Childbirth Experience ◽  
Nulliparous Women ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Abstract Background Childbirth is a unique experience that affects women’s life. Therefore, this study was performed to determine the effect of delivery ball and warm shower on the childbirth experience of primiparous women. Methods This study is a clinical trial that was carried out on primiparous pregnant women referred to Motazedi Hospital in Kermanshah, Iran. Sampling was done by continuous method and pregnant women were divided into three groups of delivery ball-warm shower (n = 33), delivery ball (n = 33) and control (n = 33). Exercise with ball at the dilation of 4 cm was similar in the two groups of delivery ball-warm shower and delivery ball, but the first group also used warm shower at the dilatation of 7 cm. The control group only received the routine delivery care. Demographic information form consisting of pregnancy history and information about the mother and infant were completed and the childbirth experience questionnaire (CEQ) were completed by the women two hours after the childbirth. Results There was a statistically significant difference in the mean score of childbirth experience after the intervention between the two groups of delivery ball-warm shower and control (P = 0.001), and also between the delivery ball and control groups (P = 0.001). There was a statistically significant difference in the mean scores of professional support between the two groups of delivery ball-warm shower and control (P = 0.02) and also between the delivery ball and control groups (p = 0.02). There was a statistically significant difference in the mean scores of participation between the two groups of delivery ball-warm shower and control (P = 0.003) and also between the delivery ball and control groups (P = 0.01). There was also a statistically significant difference in the mean scores of sense of security between the two groups of delivery ball-warm shower and control (P = 0.01). Conclusion Delivery ball and warm shower were effective interventions to create a positive childbirth experience. This method was more effective than using delivery ball alone in childbirth experience. To achieve a positive experience of childbirth in mothers, the use of both intervention (delivery ball and warm shower) is recommended.

Influência do Tratamento Crônico com L-arginina na Função Renal de Ratos Submetidos a um Modelo Experimental de Doença Renal Crônica/ Influence of Chronic Treatment with L-arginine on Renal Function in Rats Subjected to an Experimental Model of Chronic Ki

1970 ◽  
Vol 4 (4) ◽  
pp. 40-48
Author(s):  
Letícia Pereira De Castro ◽  
Niara da Cunha Borges ◽  
Patrícia Benício Laira ◽  
Nilo César do Vale Baracho
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Total Protein ◽  
Standard Dose ◽  
Unilateral Nephrectomy ◽  
Control Groups ◽  
Continuous Administration ◽  
Significant Change ◽  
And Control

 Objective: To investigate possible improvements in renal function in rats undergoing chronic renal failure treated with L-arginine. Methods: 28 rats were divided into 4 groups: Control L1- (N=7): treatment with distilled water; L2 - Moderate Uremia (N=7): supplementation with L-arginine (100 mg/kg) with unilateral nephrectomy + nephrectomy ¾ kidney against side; L3 - Moderate Uremia (N=6): supplementation with L-arginine (200 mg/kg) with unilateral nephrectomy + nephrectomy ¾ kidney against side; L4 - Moderate Uremia (N=8): supplementation with L-arginine (500 mg/kg) with unilateral nephrectomy + nephrectomy ¾ kidney against side. Results: Continuous administration of arginine L produced no significant change in creatinine dosage, urea and total protein. In glycemia L2 and L2 albumin there were minor changes. In fluid intake there were specific changes on days 6 and 8, only between L2 and control groups. Analyzing food intake, there were only significant changes (p <0.05) spot, on 5, 7 and 9 between L2 and L1 compared with the control, respectively. Regarding the urinary debit, there were significant change (p <0.01) between L3 and control. Conclusion: It was observed that L-arginine supplementation has no effect on renal failure, does not produce improvements in urea, creatinine, total protein and urinary debit. However, it produces changes in blood glucose and albumin, finding a standard dose response in statistical analysis. Keywords: L-arginine, Chronic Renal Failure, Renal Function. Objetivo: Investigar possíveis melhorias na função renal de ratos submetidos à insuficiência renal crônica e tratados com L-arginina. Metodologia: Foram utilizados 28 ratos divididos em 4 grupos: L1 - Controle (N=7): tratamento com água destilada; L2 - Uremia Moderada (N=7): suplementação com L-arginina (100mg/ kg), com nefrectomia unilateral + nefrectomia ¾ do rim contra lateral; L3 - Uremia Moderada (N=6): suplementação com L-arginina (200mg/kg) com nefrectomia unilateral + nefrectomia ¾ do rim contra lateral; L4 - Uremia Moderada (N=8): suplementação com L-arginina (500mg/kg) com nefrectomia unilateral + nefrectomia ¾ do rim contra lateral. Resultados: A administração contínua de L-arginina não produziu alterações significativas nas dosagens de creatinina, ureia e proteína total. Nas dosagens de glicemia L2 e albumina L2 houve pequenas alterações. Na ingesta hídrica foram encontradas alterações pontuais nos dias 6 e 8, apenas entre os grupos L2 e controle. Analisando a ingesta alimentar, houve apenas alterações significativas (p<0,05) pontuais, nos dias 5, 7 e 9 entre L2 e L1, quando comparados ao controle, respectivamente. Em relação ao debito urinário, existiu alteração significativa (p<0,01) entres L3 e controle. Conclusão: Foi observada que a suplementação de L-arginina não possui efeitos na insuficiência renal, não produz melhorias em ureia, creatinina, proteínas totais e debito urinário. Porém, produz alterações em glicemia e albumina, não encontrando um padrão dose resposta nas análises estatísticas. Palavras-chave: L-arginina, Insuficiência Renal Crônica, Função Renal.

scholarly journals Comparing the Effects of Acupressure at the Hugo Point and Hyoscine on the Duration of Labor Stages and Fetalneonatal Outcomes in Nulliparous Women: A Controlled Randomized Clinical Trial

2018 ◽  
Vol 7 (3) ◽  
pp. 393-399
Author(s):  
Solmaz Babazadeh Topraghlou ◽  
Fahimeh Sehhatie Shafaie ◽  
Mojgan Mirghafourvand ◽  
Narges Salehi
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Active Phase ◽  
Control Groups ◽  
Chi Square ◽  
Second Stage Of Labor ◽  
Nulliparous Women ◽  
Prolonged Labor ◽  
The Mean ◽  
And Control

Objectives: The shortened duration of labor without creating major complications is considered ideal for the mother and infant while prolonged labor is accompanied by maternal and fetal consequences. Considering its importance, the purpose of this study was to compare the effects of acupressure at the Hugo point and hyoscine on the duration of labor stages and fetal-neonatal outcomes in nulliparous women. Methods: This controlled randomized clinical trial was conducted on 162 nulliparous women who referred to Ardabil Sabalan Hospital in 2017. Participants were divided into Hugo acupressure, hyoscine, and control groups by means of randomized blocks, each containing 54 nulliparous women. In the Hugo group, the pressure exerted on the Hugo point at 5 cm dilatation and in the hyoscine group, the hyoscine was injected intramuscularly at 5 cm dilatation. Data were analyzed using one-way ANOVA, KruskalWallis, Fisher exact, and chi-square tests. Results: The mean (SD) duration of the active phase of labor was 137.0 (15.1), 143.3 (172), and 187.7 (24.7) minutes in the Hugo, hyoscine, and control groups, respectively. In addition, the mean (SD) duration of the second stage of labor in the above-mentioned groups was 39.5 (8.5), 52.4 (15.0), and 58.3 (8.7) minutes, respectively (P<0.001). Conclusions: Overall, the implementation of acupressure at the Hugo point led to a greater reduction in the duration of labor stages compared to hyoscine infusion without imposing the side-effects on mother.

scholarly journals Effect of lavender aromatherapy on well-being among hemodialysis patients: A randomized clinical trial

2018 ◽  
Author(s):  
Masoumeh Bagheri Nesami ◽  
Seyed Afshin Shorofi ◽  
Attieh Nikkhah ◽  
Hossein Roohi Moghaddam ◽  
Ali Mahdavi
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Well Being ◽  
Underlying Disease ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Experimental Group

  In spite of the improvement of dialysis techniques, hemodialysis patients still experience debilitation. Impaired functioning, well-being, and quality of life are among the factors that are of a great concern in these patients. The current study aimed to examine the effects of lavender essential oil on well-being among hemodialysis patients. This randomized clinical trial was conducted on 30 hemodialysis patients. For each patient in the experimental group, five cotton balls were prepared using two drops of lavender essence diluted with sweet almond oil. Lavender was used at five concentrations of 10%, 20%, 30%, 40%, and 50%, administered through pinning the soaked cotton ball on the patients' collar on the first, second, third, fourth, and fifth weeks of the intervention, respectively. The patients were asked to breathe normally for 20 min. On the other hand, the control group received only routine nursing care. The perceived sense of well-being was measured in both groups at the end of each week using a visual analog scale. The mean ages of patients were obtained as 58.9 ± 14.31 and 53.03 ± 15.84 years for the experimental and control groups, respectively. Hypertension was reported to be the most common underlying disease in both groups. The results showed a significant difference in the mean level of well-being in the experimental group in the fourth and fifth weeks of the intervention, compared to that before the intervention. Inhalation aromatherapy with 40% and 50% lavender essence had a positive effect on the perceived sense of well-being in hemodialysis patients. However, lower concentrations of 10%, 20%, and 30% did not exert a comparable effect.

scholarly journals The Effect of Discontinuation of Angiotensin-II Receptor Blocker on Therapeutic Effect of Synthetic Erythropoietin on Anemia Modification in Hemodialysis Patients

2019 ◽  
Vol 25 (3) ◽  
pp. 230-254
Author(s):  
Farid Reza Ejlali ◽  
◽  
Mahmood Reza Khazaei ◽  
Zahra Mostafavian ◽  
Jalil Moshari ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Hemodialysis Patients ◽  
Hemoglobin Level ◽  
Maintenance Hemodialysis ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Before And After ◽  
In The Beginning

Aims The aim of this study was to evaluate the effect of discontinuation of losartan in response to synthetic erythropoietin therapy on hemoglobin level in patients on maintenance hemodialysis. Methods & Materials This study was a pre-and post-interventional clinical trial. The population of the study was hemodialysis patients with chronic renal failure. In the beginning of the study, and three months after removal of losartan, the patients’ hemoglobin changes were compared. Findings Hemoglobin was significantly increased at the end of the study in all patients (from 10.90±1.66 at the beginning of the study to 11.37±1.42g/dl at the end of 3 months, P=0.046). No significant changes were seen in the hemoglobin level before and after intervention between patients according age, sex, and duration of the disease. Conclusion There was a significant increase in hemoglobin level at the end of study after losartan discontinuation. But this increase did not have a significant relationship with patient’s age, sex as well as the duration of the disease.

scholarly journals Evaluation of Dorema Ammoniacum and Acupuncture's Therapeutic Effects in Patients With Ischemic Stroke: A Randomized Controlled Clinical Trial 

2020 ◽  
Author(s):  
Mahsa Mehrpour ◽  
Mahdi Yousefi ◽  
Monavar AfzalAghaee ◽  
Hasan Rakhshandeh ◽  
Hoda Azizi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Ischemic Stroke ◽  
Acupuncture Group ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Control Groups ◽  
Randomized Controlled ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Abstract Aim: Stroke is the third prevalent cause of disability worldwide. This study aimed to evaluate the role of Dorema ammoniacum and acupuncture in the management of patients with stroke.Methods: In this randomized controlled clinical trial, patients with a recent ischemic stroke (within the first month of stroke) were investigated. The patients were divided into three groups. The first group was managed by acupuncture, while the second group received 1 g of Dorema ammoniacum (two 500 mg capsules per day) from ammoniacum gum. The two intervention groups also received standard treatment with routine medical therapy and physiotherapy. The final group was the control, which only received conventional treatment and physiotherapy. The patients were evaluated immediately before the interventions, and one month after the interventions, using the Modified Rankin Scale (mRS) and Modified National Institutes of Health Stroke Scale (mNIHSS).Results: There was a significant difference in the mean score of mNIHSS at the beginning and end of the study in all of the three studied groups (P<0.001). There were significant pre-treatment/post-treatment differences between the groups (P<0.001). After controlling for the effect of mNIHSS score at the beginning of the study and the follow-up visit, a significant difference was observed between the three groups regarding the mean mNIHSS score post-intervention (P<0.001). The results of the post-hoc test indicated a significant difference between the acupuncture and control groups, Dorema ammoniacum and control groups (P<0.001), acupuncture, and Dorema ammoniacum groups (P<0.001); the extent of reduction was greater in the acupuncture group. The mean mNIHSS scores of the acupuncture and Dorema ammoniacum groups were 1.82 and 1.04 lower than the control group's mean score, respectively. There was a significant difference in the mean mRS score at the beginning and end of the study in all three groups (P<0.001). However, the extent of reduction was greater in the acupuncture group.Conclusion: Acupuncture and Dorema ammoniacum may be beneficial if started within the first month of stroke incidence. However, acupuncture can cause a greater reduction in the mNIHSS score of stroke patients. Trial registration: Iranian Registry of Clinical Trials (IRCT20170227032797N2).Registered 5 March 2018 - Retrospectively registered, https://www.irct.ir/trial/25469

scholarly journals The effect of vitamin D therapy on glycemic control and biochemical indices in type 2 diabetic patients: a randomized, clinical trial study

2021 ◽  
Vol 25 (2) ◽  
pp. 125-133
Author(s):  
Majid Mozaffari ◽  
◽  
Hamed Hajmoradi ◽  
Alireza Moravveji ◽  
Fatemeh Sadat Asgarian ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Vitamin D ◽  
Glycemic Control ◽  
Control Groups ◽  
Significant Difference ◽  
The Mean ◽  
Biochemical Indices ◽  
And Control

Introduction: The aim of the present study was to evaluate the effect of vitamin D on glycemic control and biochemical indices in type 2 diabetes. Methods: This randomized double blind placebo-controlled clinical trial was conducted on 80 patients with type 2 diabetes mellitus (T2DM) referred to Shahid Beheshti hospital. These patients were randomly classified into case and control groups. Case group consumed 50,000 IU of vitamin D once a week for 12 weeks and control group placebo. Biochemical and lipid parameters and vitamin D3 were measured in two groups. Glycosylated hemoglobin (HbA1c) was assessed by latex enhance immunoturbidimetric assay. Results: There was no significant difference between case and control groups in terms of age, sex, body mass index and used medications. The mean vitamin D level in case and control groups before intervention was 15.06 ±3.307 and 15.83± 2.509 ng/ml and after intervention was 49.77 ±15.73 and 14.91±3.13 ng/ml respectively. The mean fast blood sugar in case and control groups after intervention was 156.565±32.23 and 147.75±35.06 mg/dl, respectively. The mean HbA1c in case and control groups before intervention was 7.59± 0.39 % and 7.66± 0.38 % and after intervention was 7.26 ± 0.60 and 7.60 ± 0.38, respectively. Moreover, significant difference was seen between case (20.2± 5.74 IU/L) and control groups (23.35± 7.80 IU/L) in terms of alanine aminotransferase, after intervention. Conclusion: According to these findings, vitamin D supplementation possibly through decreasing HbA1C and hepatic alanine aminotransferase could improve diabetes complications.

scholarly journals The Effect of Auriculotherapy on Pulmonary Findings and Sleep Quality in Patients with Covid 19

2021 ◽  
Author(s):  
Maryam Mohammadi ◽  
Zohreh AkhoundiMeybodi ◽  
Mahboubeh Valiani ◽  
Mohammad Sharifyazdi ◽  
Leila Asadi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Electrical Stimulation ◽  
Sleep Quality ◽  
Demographic Characteristics ◽  
Time Data ◽  
Control Groups ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
And Control

Abstract Background: Auriculotherapy is a sub-branch of acupuncture and is an effective method in acute and chronic diseases. Aim: The aim of this study was to evaluate the effect of Auriculotherapy on pulmonary findings and sleep quality in patients with Covid 19.Methods: The present study is a clinical trial study in which 70 hospitalized patients with Covid 19 with pulmonary findings and low sleep quality were randomly divided into intervention and control groups. Auriculotherapy was performed with electrical stimulation in one session and then Vakaria seed was placed in acupressure points and stimulated for one week (8 times a day for one minute each time). Data collection tools were checklist of pulmonary findings, Pittsburgh questionnaires and demographic characteristics.Results: The results showed that there was no significant difference between the mean SPO2 score in the two groups before and after the intervention (P = 0.09). There was a statistically significant difference between the mean score of dyspnea (P = 0.003), cough (P <0.008) and overall score of sleep quality in the two groups before and after the intervention (P <0.001).Conclusion: The results of this study showed that Auriculotherapy is effective on pulmonary improvements and sleep quality in patients with Covid 19.Trial registration: IRCT, IRCT20180608040007N2. Registered 13 June 2020, https://en.irct.ir/trial/48218.

scholarly journals Effects of Qingshen Granules on Immune Function in Patients with Comorbid Chronic Renal Failure and Damp-Heat Syndrome: A Multicenter, Randomized, Controlled Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Dong Wang ◽  
Yiping Wang ◽  
Chuanping Li ◽  
Shifu Liu ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Control Group ◽  
Control Groups ◽  
Randomized Controlled ◽  
Tnf Α ◽  
And Control ◽  
Heat Syndrome ◽  
Experimental Group ◽  
Necrosis Factor

Objective. The current study sought to compare the effects of the addition of Qingshen granules to conventional Western medicine on immune function in patients with comorbid chronic renal failure and damp-heat syndrome and to explore the possible mechanisms responsible for any differences observed. Methods. Through a multicenter, randomized, controlled study, a total of 282 eligible patients were divided into experimental (n = 136) and control groups (n = 146). All of the patients were treated with conventional Western medical therapy. The experimental group also received Qingshen granules three times daily for 12 weeks. Clinical efficacy was observed in the two groups. Peripheral blood levels of CD4+ T cells, CD8+ T cells, Th17 cells, nuclear factor-κB p65 (NF-κB p65) activity, serum interleukin-17 (IL-17), serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), tumor necrosis factor receptor-associated factor 6 (TRAF6), fibronectin (FN), and type IV collagen (Col-IV) were detected in both groups. Results. The total clinical curative effective rate was significantly higher p < 0.05 in the experimental group (79.41%) than in the control group (67.12%). Before treatment, there were no significant differences in CD4+/CD8+ T cell ratio, Th17 cell level, NF-κB p65 activity, serum IL-17, IL-6, TNF-α, TRAF6, FN, and Col-IV between the experimental and control groups p > 0.05 ; however, all of the measures were significantly higher than those observed in a healthy comparison group ( p < 0.05 or p < 0.01 ). After treatment, the above indexes in the experimental group were significantly lower than those before treatment ( p < 0.05 or p < 0.01 ). Similarly, NF-κB p65 activity, serum IL-17, TNF-α, TRAF6, FN, and Col-IV in the control group were significantly lower than the levels observed prior to treatment ( p < 0.05 or p < 0.01 ); however, while all of the other indexes were lower than those observed before treatment, the differences were not statistically significant p > 0.05 . Conclusion. Qingshen granules adjust immune dysfunction, improve immunity mediated inflammatory response, and attenuate renal fibrosis in patients with comorbid chronic renal failure and damp-heat syndrome.

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