scholarly journals Molecular Identification of Leishmania Species Isolated From Human Cutaneous Leishmaniasis in Poledokhtar District, Lorestan Province, Iran

2013 ◽  
Vol 6 (6) ◽  
Author(s):  
Elahe Beiranvand ◽  
Mohsen Kalantari ◽  
Hasan Ali Rastgar ◽  
Kamyar Amraee
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Molecular Identification ◽  
Leishmania Species ◽  
Human Cutaneous Leishmaniasis

scholarly journals Molecular Identification of Leishmania Species in Patient with Cutaneous Leishmaniasis in an Endemic Area of Fars Province, Southern Iran

2021 ◽  
Vol 16 (2) ◽  
pp. 105-111
Author(s):  
Vahid Rahmanian ◽  
Nader Sharifi ◽  
Zahra Kargar Jahromi ◽  
Hayedeh Parvin ◽  
Narges Rahmanian ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Molecular Identification ◽  
Endemic Area ◽  
Leishmania Species ◽  
Fars Province ◽  
Southern Iran

scholarly journals First molecular identification of Leishmania species in a new endemic area of cutaneous leishmaniasis in Lorestan, Iran

2013 ◽  
Vol 6 (9) ◽  
pp. 713-717 ◽  
Author(s):  
Farnaz Kheirandish ◽  
Ali Chegeni Sharafi ◽  
Bahram Kazemi ◽  
Mojgan Bandehpour ◽  
Mohamad javad Tarahi ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Molecular Identification ◽  
Endemic Area ◽  
Leishmania Species

The Role of CD1a expression in the diagnosis of cutaneous leishmaniasis, its relationship with Leishmania species and clinicopathological features

2021 ◽  
Author(s):  
Yasemin Yuyucu Karabulut ◽  
Funda KuŞ Bozkurt ◽  
Ümit Türsen ◽  
Gül Bayram ◽  
Gülhan Örekeci Temel ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Species ◽  
Clinicopathological Features

scholarly journals Film-Forming Systems for the Delivery of DNDI-0690 to Treat Cutaneous Leishmaniasis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 516
Author(s):  
Katrien Van Bocxlaer ◽  
Kerri-Nicola McArthur ◽  
Andy Harris ◽  
Mo Alavijeh ◽  
Stéphanie Braillard ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cutaneous Leishmaniasis ◽  
Mouse Skin ◽  
Parasite Load ◽  
Leishmania Species ◽  
Lesion Size ◽  
Drying Time ◽  
Sustained Drug Delivery ◽  
Film Forming ◽  
The Impact

In cutaneous leishmaniasis (CL), parasites reside in the dermis, creating an opportunity for local drug administration potentially reducing adverse effects and improving treatment adherence compared to current therapies. Polymeric film-forming systems (FFSs) are directly applied to the skin and form a thin film as the solvent evaporates. In contrast to conventional topical dosage forms, FFSs strongly adhere to the skin, favouring sustained drug delivery to the affected site, reducing the need for frequent applications, and enhancing patient compliance. This study reports the first investigation of the use of film-forming systems for the delivery of DNDI-0690, a nitroimidazole compound with potent activity against CL-causing Leishmania species. A total of seven polymers with or without plasticiser were evaluated for drying time, stickiness, film-flexibility, and cosmetic attributes; three FFSs yielded a positive evaluation for all test parameters. The impact of each of these FFSs on the permeation of the model skin permeant hydrocortisone (hydrocortisone, 1% (w/v) across the Strat-M membrane was evaluated, and the formulations resulting in the highest and lowest permeation flux (Klucel LF with triethyl citrate and Eudragit RS with dibutyl sebacate, respectively) were selected as the FFS vehicle for DNDI-0690. The release and skin distribution of the drug upon application to Leishmania-infected and uninfected BALB/c mouse skin were examined using Franz diffusion cells followed by an evaluation of the efficacy of both DNDI-0690 FFSs (1% (w/v)) in an experimental CL model. Whereas the Eudragit film resulted in a higher permeation of DNDI-0690, the Klucel film was able to deposit four times more drug into the skin, where the parasite resides. Of the FFSs formulations, only the Eudragit system resulted in a reduced parasite load, but not reduced lesion size, when compared to the vehicle only control. Whereas drug delivery into the skin was successfully modulated using different FFS systems, the FFS systems selected were not effective for the topical application of DNDI-0690. The convenience and aesthetic of FFS systems alongside their ability to modulate drug delivery to and into the skin merit further investigation using other promising antileishmanial drugs.

The expression of TLR9 in human cutaneous leishmaniasis is associated with granuloma

2010 ◽  
Vol 32 (11-12) ◽  
pp. 769-772 ◽  
Author(s):  
F. F. TUON ◽  
E. R. FERNANDES ◽  
C. PAGLIARI ◽  
M. I. S. DUARTE ◽  
V. S. AMATO
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Human Cutaneous Leishmaniasis

scholarly journals First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex

2015 ◽  
Vol 45 (11) ◽  
pp. 679-684 ◽  
Author(s):  
Godwin Kwakye-Nuako ◽  
Mba-Tihssommah Mosore ◽  
Christopher Duplessis ◽  
Michelle D. Bates ◽  
Naiki Puplampu ◽  
...  
Keyword(s):  
New Species ◽  
Cutaneous Leishmaniasis ◽  
Leishmania Enriettii ◽  
Human Cutaneous Leishmaniasis ◽  
A New Species

scholarly journals Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Carmen M. Sandoval Pacheco ◽  
Gabriela V. Araujo Flores ◽  
Kadir Gonzalez ◽  
Claudia M. de Castro Gomes ◽  
Luiz F. D. Passero ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Macrophage Polarization ◽  
Leishmania Species ◽  
Skin Lesions ◽  
Host Cells ◽  
M2 Macrophage ◽  
M2 Macrophages ◽  
Intracellular Parasites ◽  
Skin Biopsies ◽  
Acquired Immune Responses

Macrophages play important roles in the innate and acquired immune responses against Leishmania parasites. Depending on the subset and activation status, macrophages may eliminate intracellular parasites; however, these host cells also can offer a safe environment for Leishmania replication. In this sense, the fate of the parasite may be influenced by the phenotype of the infected macrophage, linked to the subtype of classically activated (M1) or alternatively activated (M2) macrophages. In the present study, M1 and M2 macrophage subsets were analyzed by double-staining immunohistochemistry in skin biopsies from patients with American cutaneous leishmaniasis (ACL) caused by L. (L.) amazonensis, L. (V.) braziliensis, L. (V.) panamensis ,and L. (L.) infantum chagasi. High number of M1 macrophages was detected in nonulcerated cutaneous leishmaniasis (NUCL) caused by L. (L.) infantum chagasi ( M 1 = 112 ± 12 , M 2 = 43 ± 12 cells/mm2). On the other side, high density of M2 macrophages was observed in the skin lesions of patients with anergic diffuse cutaneous leishmaniasis (ADCL) ( M 1 = 195 ± 25 , M 2 = 616 ± 114 ), followed by cases of localized cutaneous leishmaniasis (LCL) caused by L. (L.) amazonensis ( M 1 = 97 ± 24 , M 2 = 219 ± 29 ), L. (V.) panamensis ( M 1 = 71 ± 14 , M 2 = 164 ± 14 ), and L. (V.) braziliensis ( M 1 = 50 ± 13 , M 2 = 53 ± 10 ); however, low density of M2 macrophages was observed in NUCL. The data presented herein show the polarization of macrophages in skin lesions caused by different Leishmania species that may be related with the outcome of the disease.

scholarly journals Phlebotomine sand flies and Leishmania species in a focus of cutaneous leishmaniasis in Algeria

2020 ◽  
Vol 14 (2) ◽  
pp. e0008024
Author(s):  
Roumaissa Gherbi ◽  
Mustapha Bounechada ◽  
Maria Stefania Latrofa ◽  
Giada Annoscia ◽  
Viviana Domenica Tarallo ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Species ◽  
Sand Flies ◽  
Phlebotomine Sand Flies

scholarly journals Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Lucio Roberto Castellano ◽  
Laurent Argiro ◽  
Helia Dessein ◽  
Alain Dessein ◽  
Marcos Vinícius da Silva ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Therapeutic Strategy ◽  
Interleukin 10 ◽  
Leishmania Braziliensis ◽  
Soluble Antigen ◽  
Innovative Strategies ◽  
Host Protection ◽  
Human Cutaneous Leishmaniasis ◽  
Potential Use ◽  
Worse Prognosis

Interleukin-10 overproduction has been associated with worse prognosis in human cutaneous leishmaniasis, while IFN-γ-dependent responses are associated with parasite killing and host protection. Innovative strategies are needed to overcome therapeutic failure observed in endemic areas. The use of monoclonal antibody-based immunotherapy targeting IL-10 cytokine was evaluated here. Partial IL-10 blockade inLeishmania braziliensiswhole soluble antigen-stimulated cells from endemic area CL patients with active or healed lesions and asymptomatic controls was evaluated. Overall decrease in IL-10, IL-4, and TNF-αproduction was observed in all groups of subjects. Only patients with active lesions still produced some levels of TNF-αafter anti-IL-10 stimulation in association withLeishmaniaantigens. Moreover, this strategy showed limited modulatory effects on IFN-γ-dependent chemokine CXCL10 production. Results suggest the potential immunotherapeutic use of partial IL-10 blockade in localized cutaneous leishmaniasis.

scholarly journals Correction to: Molecular identification of Leishmania spp. isolates causes cutaneous leishmaniasis (CL) in Sanliurfa Province, Turkey, where CL is highly endemic

2018 ◽  
Vol 63 (3) ◽  
pp. 361-361
Author(s):  
Gulcan Gurses ◽  
Mehmet Ozaslan ◽  
Fadile Yıldız Zeyrek ◽  
Ibrahim H. Kılıç ◽  
Nebiye Yentür Doni ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Molecular Identification ◽  
Leishmania Spp
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