scholarly journals The Prevalence of Helicobacter pylori Virulence Related Genes (hpa and babA2) in Iranian Patients with Gastrointestinal Disorders

2017 ◽  
Vol 10 (12) ◽  
Author(s):  
Khatoon Heidari ◽  
Vahideh Kazem Nezhad ◽  
Alireza Noroozi ◽  
Fatemeh Mehravar
Keyword(s):  
Helicobacter Pylori ◽  
Gastrointestinal Disorders ◽  
Iranian Patients

scholarly journals Lack of Association of Interleukin-8 Gene Polymorphism with Helicobacter pylori-Induced Gastritis in Iranian Patients

2008 ◽  
Vol 12 ◽  
pp. e213
Author(s):  
S.H. Farshad ◽  
M. Rasouli ◽  
A. Jamshidzadeh ◽  
A. Hosseinkhani ◽  
A. Japoni ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gene Polymorphism ◽  
Interleukin 8 ◽  
Iranian Patients

scholarly journals Helicobacter pylori and Metabolic Diseases

2020 ◽  
Vol 20 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Sung Eun Kim
Keyword(s):  
Helicobacter Pylori ◽  
Fatty Liver Disease ◽  
Metabolic Diseases ◽  
Gastrointestinal Disorders ◽  
Systemic Effects ◽  
Peptic Ulcers ◽  
Alcoholic Fatty Liver ◽  
H Pylori ◽  
The Relationship ◽  
Alcoholic Fatty Liver Disease

<i>Helicobacter pylori</i> (<i>H. pylori</i>) is one of the most common pathogens that can cause certain gastrointestinal disorders, such as gastritis, peptic ulcers, and gastric cancer. Recently, interest in the systemic effects of <i>H. pylori</i> on extragastric manifestations is increasing. Representative diseases include hematologic, cardiovascular, neurodegenerative, autoimmune, dermatologic, allergic, hepatobiliary, and metabolic diseases. Among them, since the prevalence of metabolic diseases is on the rise worldwide, the relationship between <i>H. pylori</i> infection and metabolic diseases has become an interesting research issue. Many studies have been conducted to clarify any association. However, the results of those studies still remain controversial. This review focuses on recently published studies to investigate the relationship between <i>H. pylori</i> infection and metabolic diseases, including diabetes mellitus, metabolic syndrome, obesity, and non-alcoholic fatty liver disease, and their associated pathophysiology.

scholarly journals Genetic Variants in PTGS1 and NOS3 Genes Increase the Risk of Upper Gastrointestinal Bleeding: A Case–Control Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Marcela Forgerini ◽  
Gustavo Urbano ◽  
Tales Rubens de Nadai ◽  
Sabrina Setembre Batah ◽  
Alexandre Todorovic Fabro ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastrointestinal Bleeding ◽  
Genetic Variants ◽  
Case Control Study ◽  
Upper Gastrointestinal Bleeding ◽  
Case Control ◽  
Gastrointestinal Disorders ◽  
Increased Risk ◽  
Upper Gastrointestinal ◽  
Control Study

Objective: To assess the association between PTGS1 and NOS3 variant alleles and the risk to develop upper gastrointestinal bleeding (UGIB) secondary to complicated peptic disease.Methods: A case–control study was conducted in a Brazilian complex hospital from July 2016 to March 2020. Case: Patients with UGIB diagnosis. Control: Patients admitted for surgery not related to gastrointestinal disorders. Variables: UGIB (outcome), genetic variants in PTGS1 and NOS3 genes (independent), and sex, age, schooling, ethnicity, previous history of gastrointestinal disorders, Helicobacter pylori serology, comorbidity, drug therapy, and lifestyle (confounding). The single-nucleotide polymorphisms (SNPs) of the PTSG1 gene (rs1330344, rs3842787, rs10306114, and rs5788) and NOS3 gene (rs2070744 and rs1799983) were determined using the real-time polymerase chain reaction. Helicobacter pylori serology was determined through the chemiluminescence technique. Logistic regression models were built and deviations of allelic frequencies from Hardy–Weinberg equilibrium were verified.Results: 200 cases and 706 controls were recruited. Carriers of the AG genotype of rs10306114 (OR: 2.55, CI 95%: 1.13–5.76) and CA + AA genotypes of rs5788 (OR: 2.53, CI 95%: 1.14–5.59) were associated with an increased risk for the UGIB development. In nonsteroidal anti-inflammatory drugs (NSAIDs) users, the six variants evaluated modified the magnitude of the risk of UGIB, whereas in low-dose aspirin (LDA) users, an increased risk of UGIB was observed for four of them (rs1330344, rs10306114, rs2070744, and rs1799983). Personal ulcer history (p-value: &lt; 0.001); Helicobacter pylori infection (p-value: &lt; 0.011); NSAIDs, LDA, and oral anticoagulant use (p-value: &lt; 0.001); and alcohol intake (p-value: &lt; 0.001) were also identified as independent risk factors for UGIB.Conclusion: This study presents two unprecedented analyses within the scope of the UGIB (rs10306114 and rs2070744), and our findings showing an increased risk of UGIB in the presence of the genetic variants rs10306114 and rs5788, regardless of the drug exposure. Besides, the presence of the evaluated variants might modify the magnitude of the risk of UGIB in LDA/NSAIDs users. Therefore, our data suggest the need for a personalized therapy and drug use monitoring in order to promote patient safety.

A systematic review and meta-analysis of outcomes of infection with Helicobacter pylori dupA+ strains in Iranian patients

Gene Reports ◽  
2020 ◽  
Vol 19 ◽  
pp. 100650 ◽  
Author(s):  
Masoud Youssefi ◽  
Kiarash Ghazvini ◽  
Hadi Farsiani ◽  
Mohsen Tafaghodi ◽  
Masoud Keikha
Keyword(s):  
Systematic Review ◽  
Helicobacter Pylori ◽  
Meta Analysis ◽  
Iranian Patients

Evaluation of Helicobacter pylori vacA Genotypes in Iranian Patients with Peptic Ulcer Disease

2008 ◽  
Vol 54 (11) ◽  
pp. 2399-2403 ◽  
Author(s):  
Zivar Salehi ◽  
Ali Saber Hossein Abadi ◽  
Patimah B. T. Ismail ◽  
Cheah Yoke Kqueen ◽  
Mohammad Halimi Jelodar ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Ulcer Disease ◽  
Iranian Patients

scholarly journals Clarithromycin-Susceptible But Virulent Helicobacter pylori Strains Infecting Iranian Patients’ Stomachs

2019 ◽  
Vol Volume 12 ◽  
pp. 3415-3420 ◽  
Author(s):  
Shadiyeh Khani ◽  
Amin Talebi Bezmin Abadi ◽  
Ashraf Mohabati Mobarez
Keyword(s):  
Helicobacter Pylori ◽  
Iranian Patients
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