scholarly journals The Effect of Zufa Versus Chlorhexidine Gluconate Mouthwashes on Oral Flora of Patients Under Mechanical Ventilation in the Intensive Care Unit: A Double-Blind, Randomized Clinical Trial

2019 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Abbasali Ebrahimian ◽  
Raheb Ghorbani ◽  
Mehrooz Alishah ◽  
Alieh Zamani ◽  
Niloofar Kianvash-Rad ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Randomized Clinical Trial ◽  
Chlorhexidine Gluconate ◽  
Double Blind ◽  
Oral Flora

scholarly journals Comparing the Effect of Neostigmine and Metoclopramide on Gastric Residual Volume of Mechanically Ventilated Patients in Intensive Care Unit: A Double-Blind Randomized Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Alireza Rahat-Dahmardeh ◽  
Sara Saneie-Moghadam ◽  
Masoum Khosh-Fetrat
Keyword(s):  
Clinical Trial ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Randomized Clinical Trial ◽  
Normal Saline ◽  
Residual Volume ◽  
Gastric Residual Volume ◽  
Double Blind ◽  
Icu Patients ◽  
Mechanically Ventilated

Introduction. The gastric residual volume (GRV) monitoring in patients with mechanical ventilation (MV) is a common and important challenge. The purpose of this study was to compare the effect of neostigmine and metoclopramide on GRV among MV patients in the intensive care unit (ICU). Methods. In a double-blind randomized clinical trial, a total of 200 mechanically ventilated ICU patients with GRV > 120   ml (6 hours after the last gavage) were randomly assigned into two groups (A and B) with 100 patients in each group. Patients in groups A and B received intravenous infusion of neostigmine at a dose of 2.5 mg/100 ml normal saline and metoclopramide at a dose of 10 mg/100 ml normal saline, within 30 minutes, respectively. GRV was evaluated 5 times for each patient, once before the intervention and 4 times (at 3, 6, 9, and 12 hours) after the intervention. In addition, demographic characteristics including age and gender, as well as severity illness based on the sequential organ failure assessment score (SOFA), were initially recorded for all patients. Results. After adjusting of demographic and clinical characteristics (age, gender, and SOFA score), the generalized estimating equation (GEE) model revealed that neostigmine treatment increased odds of GRV improvement compared to the metoclopramide group ( OR = 2.45 , 95% CI: 1.60-3.76, P < 0.001 ). However, there is a statistically significant time trend (within-subject differences or time effect) regardless of treatment groups ( P < 0.001 ). Conclusion. According to the results, although neostigmine treatment significantly improved GRV in more patients in less time, within 12 hours of treatment, all patients in both groups had complete recovery. Considering that there was no significant difference between the two groups in terms of side effects, it seems that both drugs are effective in improving the GRV of ICU patients.

Comparison of effectiveness of two urinary drainage systems in intensive care unit: a prospective, randomized clinical trial

2003 ◽  
Vol 29 (3) ◽  
pp. 410-413 ◽  
Author(s):  
Marc Leone ◽  
Franck Garnier ◽  
Fran�ois Antonini ◽  
Marie-Christine Bimar ◽  
Jacques Alban�se ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Randomized Clinical Trial ◽  
Drainage Systems ◽  
Prospective Randomized Clinical Trial ◽  
Urinary Drainage ◽  
Comparison Of Effectiveness
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