scholarly journals Protective Effect of Tragopogon Graminifolius DC Against Ethanol Induced Gastric Ulcer

2013 ◽  
Vol 15 (9) ◽  
Author(s):  
Mohamad Hosein Farzaei ◽  
Mozafar Khazaei ◽  
Zahra Abbasabadei ◽  
Maryam Feyzmahdavi ◽  
Gholam Reza Mohseni
Keyword(s):  
Gastric Ulcer ◽  
Protective Effect ◽  
Tragopogon Graminifolius

Protective effect of the new compound — salicyl-carnosine — on the formation of chronic acetate gastric ulcer in rats*

2019 ◽  
Vol 163 (3) ◽  
pp. 58-64
Author(s):  
I.E. Trubitsyna ◽  
◽  
S.L. Stvolinsky ◽  
O.I. Kulikova ◽  
T.N. Fedorova ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Protective Effect

scholarly journals Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Enrico Gugliandolo ◽  
Marika Cordaro ◽  
Roberta Fusco ◽  
Alessio Filippo Peritore ◽  
Rosalba Siracusa ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Inflammatory Response ◽  
Protective Effect ◽  
Underlying Mechanism ◽  
New Drugs ◽  
Ethanol Administration ◽  
Common Disease ◽  
Intragastric Administration ◽  
Human Disorders ◽  
Interest In Research

AbstractGastric ulcer or peptic ulcer is a common disease worldwide. Basically, it develops when there is an imbalance between the protective and aggressive factors, especially at the luminal surface of epithelial cells. Thus, there is a constant interest in research new drugs for treatment of gastric ulcer. The snail secretion is a dense mucous, that covers the external surface of the snails, with important functions for the survival of snails. The biological proprieties of snail Helix Aspersa Muller mucus it has been known for centuries to treat human disorders in particular for skin disease. Recently the use of snail mucus has seen a worldwide increase, as a component in cosmetic product and it has been used in particular for the management of wound and skin disorders. In this study we use a murine model of ethanol intragastric administration which has been widely used to test the drugs efficacies and to explore the underlying mechanism for gastric ulcer development. The intragastric ethanol administration causes several mucosal damages and an induction of a severe inflammatory response. Our results show a significant protective effect of snail secretion filtrate in reducing macroscopic and histological lesions, as well the protective effect on mucus content, oxidative stress and inflammatory response. In conclusion this study demonstrate the protective effect of intragastrical snail secretion filtrate, in a model of ethanol-induced gastric ulcer in mice, suggesting its possible useful use in the treatment or prevention of gastric ulcer.

A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats

2019 ◽  
Vol 46 (5) ◽  
pp. 4843-4860 ◽  
Author(s):  
Amy Fakhry Boushra ◽  
Asmaa Mohammed Elsayed ◽  
Noha Abdellatif Ibrahim ◽  
Maha Khaled Abdelwahed ◽  
Eman Ibrahim Ahmed
Keyword(s):  
Gastric Ulcer ◽  
Comparative Study ◽  
Protective Effect ◽  
Albino Rats

scholarly journals Histopathological Evaluation of Gastro Protective Effect of Trigonella Foenum Graecum Seed (Methi) and omeprazole in Experimentally Induced Gastric Ulcer in Rats

2020 ◽  
Vol 28 (1) ◽  
pp. 67-75
Author(s):  
Rumana Afroz ◽  
Md Ismail Khan ◽  
Kazi Afzalur Rahman ◽  
Mahbuba Jahan Lotus ◽  
Mir muhammad Shoyeb Shahabuddin ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Protective Effect ◽  
Ethanolic Extract ◽  
Developed Countries ◽  
Histopathological Analysis ◽  
Peptic Ulcers ◽  
Gastric Diseases ◽  
Major Drawback ◽  
Medical College ◽  
Trigonella Foenum Graecum

Context: Peptic ulcer is a common disorder of the stomach and duodenum. Bangladesh is a developing country with a very high point prevalence of duodenal ulcer disease (11.9%) and a H. pylori prevalence of more than 90% in asymptomatic adults and 80% in children at the age of 5 years. The multifactorial pathogenesis of peptic ulcers is secretion of gastric acid. The main therapeutic target is the control of this secretion using antacids, H2 receptor blockers (ranitidine, famotidine) or proton pump blockers (omeprazole and lansoprazole). However, nowadays, gastric ulcer therapy faces a major drawback because most of the drugs currently available in the market show limited efficacy against gastric diseases and are often associated with severe side effects. Thus, there is an urgent need to identify more effective and safe antiulcer agents. In this context, the use of medicinal plants for the prevention and treatment of different pathologies is in continuous expansion worldwide. From the ancient time, various plants were used in traditional medicine with reputation as efficacious remedies. The list of plant derived modern medicine is very long now. About 33% of the drugs produced in the developed countries are derived from plants. Trigonella foenum-graecum (Fenugreek, Methi) is one of them used in many parts of world. Preliminary study on animal showed that Trigonella foenum-graecum seed has significant gastro-protective effect. A study was carried out to demonstrate the gastro-protective effect of aqueous extract and ethanolic extract of Trigonella foenum-graecum seed (Fenugreek, Methi) and omeprazole on ethanol induced gastric ulcer in experimental rats. Material and Methods: The present study was performed on 24 (twenty four) rats which were divided randomly into 4 groups each having 6 rats in the Pharmacology Department of Dhaka Medical college, Dhaka. 1 ml of absolute ethanol (5ml/kg body wt.) was orally administered to all groups by gastric intubations to induce gastric ulcer in all groups except normal control. Omeprazole suspension (20mg/kg body wt) was used as synthetic anti ulcer drug in study. Aqueous and ethanolic extract of Trigonella foenum-graecum seed(500mg/kg body wt) were used respectively orally. Histopathological analysis was carried out to evaluate the gastroprotective activity of aqueous and ethanolic extract of Trigonella foenum-graecum seed and omeprazole on ethanol induced gastric ulcer in experimental rats. Result: Pretreatment with aqueous and ethanolic extract of Trigonella foenum-graecum seed (500mg/kg/body wt) showed very significant prevention in ethanol induced gastric ulcer. Results of the study showed that in case of ethanol treated rats gross examination showed a large amount of haemorrhagic lesions confined mostly in the gastric corpus. Histologically lesion involved about two-third of the mucosa layer and exfoliation of the mucosal cells was detected. Meanwhile, red blood cells were present in the gastric mucosa and edematous submucosa was discovered. However aqueous and ethanolic extract of Trigonella foenum-graecum seed significantly reduced the haemorrhagic lesions, tissue proliferation, infiltration of cells and sloughing induced by ethanol. This prevention was statistically very significant (P<0.001). Conclusion: The aqueous and ethanol extracts of Trigonella foenum-graecum seed and omeprazole possess gastro protective properties. J Dhaka Medical College, Vol. 28, No.1, April, 2019, Page 67-75

scholarly journals Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice1

2005 ◽  
Vol 26 (11) ◽  
pp. 1334-1338 ◽  
Author(s):  
Long-rui PAN ◽  
Qiang TANG ◽  
Qin FU ◽  
Ben-rong HU ◽  
Ji-zhou XIANG ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gastric Ulcer ◽  
Protective Effect

The Protective Effect of Vanadium Sulphate on Ethanol-Induced Gastric Ulcer

2013 ◽  
Vol 35 (4) ◽  
pp. 175-179
Author(s):  
Mohame Kemeir ◽  
Abdelmaged El-Hassan
Keyword(s):  
Gastric Ulcer ◽  
Protective Effect

Protective effect of polyamine extract of salt stressed and sprouted soybean seeds against ethanol-induced gastric ulcer in rats

2014 ◽  
Vol 23 (3) ◽  
pp. 711-716 ◽  
Author(s):  
Kandhasamy Sowndhararajan ◽  
Souren Paul ◽  
Gi Seok Kwon ◽  
Cher Won Hwang ◽  
Sun Chul Kang
Keyword(s):  
Gastric Ulcer ◽  
Protective Effect ◽  
Soybean Seeds

Protective effect of chelerythrine against ethanol-induced gastric ulcer in mice

2014 ◽  
Vol 208 ◽  
pp. 18-27 ◽  
Author(s):  
Wei-Feng Li ◽  
Ding-Jun Hao ◽  
Ting Fan ◽  
Hui-Min Huang ◽  
Huan Yao ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Protective Effect
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