scholarly journals A Case-Control Study of the Relationship Between SLC22A3-LPAL2-LPA Gene Cluster Polymorphism and Coronary Artery Disease in the Han Chinese Population

2016 ◽  
Vol 18 (6) ◽  
Author(s):  
Zi-Kai Song ◽  
Hong-Yan Cao ◽  
Hai-Di Wu ◽  
Li-Ting Zhou ◽  
Ling Qin
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Cluster ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Han Chinese Population ◽  
Artery Disease ◽  
The Relationship ◽  
Control Study

scholarly journals Relationship between Long Noncoding RNA H19 Polymorphisms and Risk of Coronary Artery Disease in a Chinese Population: A Case-Control Study

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Wei-na Hu ◽  
Han-xi Ding ◽  
Qian Xu ◽  
Xue-ying Zhang ◽  
Da-tong Yang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Long Noncoding Rna ◽  
Chinese Population ◽  
Noncoding Rna ◽  
Case Control Study ◽  
Case Control ◽  
Major Health Problem ◽  
Artery Disease ◽  
Control Study

Background/Aim. Coronary artery disease (CAD) is a major health problem that has high morbidity and mortality around the world. In recent years, long noncoding RNA H19 has been reported to affect the proliferation and apoptosis of vascular cells, which directly or indirectly results in atherosclerosis. We performed a case-control study to explore the relationship between H19 gene polymorphisms (rs2735971, rs2839698, and rs3024270) and the risk of CAD. Methods. We collected 732 samples from Liaoning Province, China, and three polymorphisms in long noncoding RNA H19 were genotyped using the KASP platform. Results. Our data showed that H19 rs2735971 and rs3024270 variant genotypes were associated with a decreased risk of CAD (rs2735971, P=0.003, odds ratio OR=0.6195, 95% confidence interval=0.44−0.84; rs3024270, P=0.030, OR=0.65, 95% confidence interval=0.44−0.96). No significant association with the risk of CAD was found for H19 rs2839698 polymorphism (P>0.05). In haplotype analysis, H19 polymorphisms of rs2735971-rs2839698-rs3024270 A-C-C haplotype reduced the risk of CAD by 0.61-fold (P=0.004, OR=0.61, 95% confidence interval=0.43–0.86). In addition, we found that rs2839698 interacted with smoking (Pinteraction=0.027), and according to multifactor dimensionality reduction analysis, the three-factor model including H19 rs2839698-smoking-drinking was the best model for the risk of CAD (testing balanced accuracy=0.6979). Conclusion. Our study demonstrated that some genotypes of H19 rs2735971 and rs3024270 polymorphisms, as well as rs2735971-rs2839698-rs3024270 A-C-C haplotype, were associated with the risk of CAD in a Chinese population, and these genotypes have the potential to be biomarkers for predicting CAD risk. We also found that rs2735971-rs2839698-rs3024270 A-C-C may have a significantly lower risk of CAD. The recessive genetic model of rs3024270 could predict the severity of CAD.

scholarly journals P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: A case control study

2020 ◽  
Author(s):  
Li Shen ◽  
Tianlun Yang ◽  
Ke Xia ◽  
Zhiqiang Yan ◽  
Juanjuan Tan ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Platelet Activation ◽  
Case Control Study ◽  
Case Control ◽  
Platelet Surface ◽  
Coronary Syndromes ◽  
Artery Disease ◽  
The Relationship ◽  
Control Study

Abstract Background: Platelet activation plays a crucial role in the pathogenesis of coronary artery disease (CAD).Platelet P-selectin (CD62P) is a platelet classic activation indicator on the platelet surface,and soluble TREM-like transcript-1 (sTLT-1) is a new indicator;hpwever, the relationship between these two markers and CAD(especially in acute coronary syndromes (ACS) has not been elucidated. This study aimed to investigate the expression of CD62Pon the platelet surface and sTLT-1 in serum and to assess their relationship with CAD.Methods: We measured the levels of CD62P and sTLT-1 in 83 patients with CAD compared to 49 controls. The associations with age, blood pressure, lipid profiles, body mass index and liver injury marker levels were also examined.Results: A stepwise increase in CD62P concentration was found based on the number of CAD patients (P <0.01), especially in Acute myocaedial infarction( AMI) patients (P <0.01). Serum sTLT-1 concentration in the AMI and Unstable angina pectoris(UAP) groups was higher than that in the Normal control (NC) group (P <0.01).Conclusions: The consistency of sTLT-1 and CD62P expression levels in CAD indicates that the sTLT-1 level may be a new marker of platelet activation and is positively related to CAD.

Effects of genetic and nongenetic factors on hyperuricemia in Chinese patients with coronary artery disease

2021 ◽  
Author(s):  
Weixia Zhang ◽  
Yiwen Jin ◽  
Juan Li ◽  
Jingjing Huang ◽  
Hefeng Chen
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Case Control Study ◽  
Direct Sequencing ◽  
Case Control ◽  
Dose Effect ◽  
Chinese Patients ◽  
Artery Disease ◽  
The Relationship ◽  
Control Study

Aim: The relationship between hyperuricemia and polymorphisms of transporter genes in coronary artery disease (CAD) patients in China remains unclear. Materials & methods: A total of 258 hyperuricemia patients with CAD and 242 control patients with CAD were recruited in this case–control study. Twenty-four SNPs in genes of ABCG2, PDZK1, URAT1, OAT4, GLUT9, ABCC4, NPT1 and NPT4 were genotyped using direct sequencing in all subjects. Results: The mutation of ABCG2 rs2231142 locus increases the risk of hyperuricemia, and there is a gene dose effect in the influence of mutant heterozygotes and homozygotes. rs3825017 in URAT1 and rs62293298 in GLUT9 were also confirmed to be associated with hyperuricemia. Conclusion: Age, weight, creatinine clearance rate, diuretics and SNPs on ABCG2, URAT1 and GLUT9 were all risk factors of hyperuricemia.

scholarly journals Complement C3 gene polymorphisms are associated with lipid levels, but not the risk of coronary artery disease: a case-control study

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Gaojun Cai ◽  
Li Li ◽  
Yifei Chen ◽  
Haomin Huang ◽  
Lei Yu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Apolipoprotein A1 ◽  
Lipid Levels ◽  
Artery Disease ◽  
Control Study

Abstract Background Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Previous studies have shown that complement component 3 (C3) is associated with atherosclerosis and cardiovascular risk factors. Methods We conducted this study to evaluate the associations between tagSNPs in the C3 gene locus and the CAD susceptibility and lipid levels in the Chinese population. A hospital-based case-control study, including 1017 subjects (580 CAD patients and 437 non-CAD controls), was conducted. TagSNPs in the C3 gene were searched and genotyped by using the polymerase chain reaction-ligase detection reaction method. Results The C3 levels were positively associated with the low-density lipoprotein cholesterol (LDL-C) levels (r = 0.269, P = 0.001). Compared with those in controls, the serum C3 levels in CAD patients were significantly higher (Control: 0.94 + 0.14 g/l; CAD: 1.10 + 0.19 g/l, P < 0.001). No significant differences in genotype or allele frequencies were observed between CAD patients and controls. The minor T allele of rs2287848 was associated with low apolipoprotein A1 (ApoA1) levels in controls (Bonferroni corrected P, Pc = 0.032). Linkage disequilibrium and haplotype analysis established two haplotype blocks (Block1: rs344555-rs2277984, Block 2: rs2287848-rs11672613) and six haplotypes. No significant associations between haplotypes and the risk of CAD were observed (all Pc > 0.05). Conclusions The results revealed that C3 gene polymorphisms were associated with the lipid levels, but not CAD susceptibility in the Chinese population.

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