scholarly journals The Effects of Chemical Castration with Degarelix on Bone Turnover: Densitometric and Biomechanics Bone Properties of Male Rats

2018 ◽  
Vol 16 (3) ◽  
Author(s):  
Putri Ayu Jayusman ◽  
Isa Naina Mohamed ◽  
Ahmad Nazrun Shuid
Keyword(s):  
Bone Turnover ◽  
Male Rats ◽  
Chemical Castration ◽  
Bone Properties

Effect of age on alveolar bone turnover adjacent to maxillary molar roots in male rats: A histomorphometric study

2007 ◽  
Vol 52 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Yasuko Misawa ◽  
Toru Kageyama ◽  
Keita Moriyama ◽  
Saburo Kurihara ◽  
Hiroshi Yagasaki ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Alveolar Bone ◽  
Male Rats ◽  
Histomorphometric Study ◽  
Maxillary Molar ◽  
Effect Of Age

scholarly journals Assessment of fertility in male rats after extended chemical castration with a GnRH antagonist

AAPS PharmSci ◽  
2004 ◽  
Vol 6 (1) ◽  
pp. 94-99 ◽  
Author(s):  
Susan S. D'Souza ◽  
Francesca Selmin ◽  
Santos B Murty ◽  
Wei Qiu ◽  
BC Thanoo ◽  
...  
Keyword(s):  
Gnrh Antagonist ◽  
Male Rats ◽  
Chemical Castration

scholarly journals The Short-Term Effects of Prunes in Preventing Inflammation and Improving Indices of Bone Health in Osteopenic Men

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 5-5
Author(s):  
Bahram Arjmandi ◽  
Kelli George ◽  
Lauren Ormsbee ◽  
Neda Akhavan ◽  
Joseph Munoz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Bone Loss ◽  
Bone Turnover ◽  
Systolic Blood Pressure ◽  
Dietary Intervention ◽  
Male Rats ◽  
Health Concern ◽  
Control Group ◽  
Daily Consumption ◽  
Significant Group

Abstract Objectives Osteoporosis is a public health concern for both women and men. Chronic inflammation contributes to bone loss; therefore, foods rich in antioxidants, such as prunes, are of great interest. Previously, dietary intervention with prunes has been shown to prevent orchidectomy-induced decreases in BMD, microstructure, and biomechanics in male rats; however, there is a need for this to be studied in a clinical setting in adult males. Methods Thirty-five men between the ages of 55 and 80 with moderate bone loss were included. The men were randomized into one of three groups: 100 g prunes daily, 50 g prunes daily, or control group. All three groups also consumed a multivitamin containing 450 mg calcium and 800 IU vitamin D. Serum samples from the baseline and three-month time points were analyzed for biomarkers of bone turnover, inflammation, and oxidative stress. Results After three months, daily consumption of 100 g prunes was associated with a significant decrease in serum concentrations of osteocalcin (P < 0.001). Consumption of 50 g of prunes was associated with significant decreases in systolic blood pressure, and serum osteocalcin concentrations (P = 0.040), and an increase in the OPG: RANKL ratio (P = 0.041). There were also significant decreases in systolic blood pressure, OPG (P = 0.004), RANKL (P = 0.010), and osteocalcin (P = 0.049) in control group. There was a significant group*time effect for changes in OPG (P = 0.019) and the OPG: RANKL ratio (P = 0.029). Conclusions Decreases in osteocalcin indicate a decrease in bone turnover, and a higher OPG: RANKL ratio indicates that more RANKL is bound to OPG, and not to osteoclasts, thus downregulating osteoclast activity. Therefore, regular consumption of either 100 g or 50 g dried plum for three months may make some contributions to bone formation and bone turnover activity, and minimal contribution to decreasing inflammation and improving bone density and quality. Funding Sources USDA/NIFA, California Prune Board, and Shaklee.

Bone Response to Exercise During Recovery Between Unloading Bouts in Adult Male Rats

2012 ◽  
Author(s):  
Y. Shirazi-Fard ◽  
E. Gonzalez ◽  
D. S. Morgan ◽  
J. M. Davis ◽  
K. L. Shimkus ◽  
...  
Keyword(s):  
Bone Mineral ◽  
Space Station ◽  
Male Rats ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Mechanical Unloading ◽  
Exercise Regimen ◽  
Bone Properties ◽  
Bone Response ◽  
Response To Exercise

Mechanical unloading has deleterious effects on the musculoskeletal system, and exercise offers a way to reduce or reverse these effects. Studies of crew members from the International Space Station have documented bone losses that do not fully recover even years after returning to Earth [1,2], and this raises concerns with repeated missions. We have used the adult hindlimb unloaded (HU) rat model [3] to simulate repeated exposure to microgravity, and to study densitometric and mechanical properties at multiple bone sites. This study focuses on mixed bone sites including proximal tibia metaphysis (PTM), and femoral neck (FN) region which also has a significant clinical relevance. Surprisingly, losses for the 2nd HU were milder than those for the 1st HU for bone mineral content (BMC) and volumetric bone mineral density (vBMD), suggesting a possible protective effect of the 1st HU [4]. Comparison to a separate group exposed to a single period of HU initiated at the same age as the 2nd HU group ruled out age effects contributing to the smaller deficit. BMC and vBMD values returned to baseline but remained below aging cage control (CC) values, raising the question of whether the milder losses for the 2nd HU might be attributable, wholly or partially, to lower levels at the start of the 2nd HU. The goal of the current study was to determine if adding a resistance exercise regimen during recovery from the 1st HU would restore bone properties to CC levels and/or significantly affect the response to the 2nd HU.

Stanozolol Decreases Bone Turnover Markers, Increases Mineralization, and Alters Femoral Geometry in Male Rats

2016 ◽  
Vol 98 (6) ◽  
pp. 609-618 ◽  
Author(s):  
E. Nebot ◽  
V. A. Aparicio ◽  
D. Camiletti-Moirón ◽  
R. Martinez ◽  
R. G. Erben ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Male Rats ◽  
Femoral Geometry ◽  
Turnover Markers

scholarly journals Bone Structural, Biomechanical and Histomorphometric Characteristics of the Postcranial Skeleton of the Marsh Rice Rat (Oryzomys palustris)

2021 ◽  
Author(s):  
E. J. Castillo ◽  
S. Croft ◽  
J.M Jiron ◽  
J.I. Aguirre
Keyword(s):  
Bone Turnover ◽  
Bone Mineral ◽  
Female Rats ◽  
Male Rats ◽  
Appendicular Skeleton ◽  
Postcranial Skeleton ◽  
Mineral Density ◽  
Bone Formation Rate ◽  
Trabecular Thickness ◽  
Oryzomys Palustris

AbstractINTRODUCTIONThe rice rat (Oryzomys palustris) is a non-conventional laboratory rodent species used to model some human bone disorders. However, no studies have been conducted to characterize the postcranial skeleton. Therefore, we aimed to investigate age- and gender-related features of the appendicular skeleton of this species.METHODSWe used femurs and tibiae from 94 rats of both genders aged 4-28 wks. Bone mineral content (BMC), bone mineral density (BMD), and biomechanical properties were determined in femurs. In addition, bone histomorphometry of tibiae was conducted to assess bone cells activities and bone turnover over time.RESULTSBodyweight, bone length, total metaphysis BMC/BMD, cortical BMC/BMD, cortical thickness, and cortical area progressively augmented with age. Whereas the increase in these parameters plateaued at age 16-22 wks in female rats, they continued to rise to age 28 wks in male rats. Furthermore, bone strength parameters increased with age, with few differences between genders. We also observed a rapid decrease in longitudinal growth between ages 4-16 wks. Whereas young rats had a greater bone formation rate and bone turnover, older rice rats had greater bone volume and trabecular thickness, with no differences between genders.CONCLUSIONS1) Sexual dimorphism in the rice rat becomes grossly evident at age 16 wks; 2) the age-related increases in bone mass, structural cortical parameters, and in some biomechanical property parameters plateau at an older age in male than in female rats; and 3) bone growth and remodeling significantly decreased with age indistinctive of the gender.

Calcium homeostasis, bone turnover and bone mass in androgen resistant (testicular feminized) male rats

1992 ◽  
Vol 17 ◽  
pp. 166
Author(s):  
D. Vanderschueren ◽  
E. Van Herck ◽  
I. Jans ◽  
K.W. Chung ◽  
R. Bouillon
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Calcium Homeostasis ◽  
Male Rats
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