scholarly journals Visfatin and Resistin Serum Levels in Normal-Weight and Obese Women With Polycystic Ovary Syndrome

2014 ◽  
Vol 12 (3) ◽  
Author(s):  
Fatemeh Farshchian ◽  
Fahimeh Ramezani Tehrani ◽  
Houshang Amirrasouli ◽  
Hooman Rahimi Pour ◽  
Mehdi Hedayati ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Normal Weight ◽  
Obese Women ◽  
Ovary Syndrome

scholarly journals Insulin Resistance and Polycystic ovary Syndrome: A Review

2019 ◽  
Vol 9 (1-s) ◽  
pp. 433-436 ◽  
Author(s):  
Mudasir Maqbool ◽  
Mohmad Amin Dar ◽  
Imran Gani ◽  
Mohammad Ishaq Geer
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Cell Function ◽  
Polycystic Ovary ◽  
Hepatic Clearance ◽  
Normal Weight ◽  
Obese Women ◽  
Primary Defect ◽  
Ovary Syndrome ◽  
Insulin Metabolism

Polycystic Ovary Syndrome (PCOS) is the most common, yet complex, endocrine disorder affecting women in their reproductive years and is a leading cause of infertility. This disease appears to be multifactorial and polygenic in nature involving multisystem dysfunction, namely reproduction, endocrine and metabolic. Hyperandrogenism and insulin resistance appear to be central cause to the pathophysiology of the disease. The glucose and insulin metabolism pathways have been studied and debated to understand whether Insulin Resistance is due to a defect in insulin action or a primary defect in β-cell function or decreased hepatic clearance of insulin, or a combination of all these factors. Numerous studies have demonstrated that obese, normal weight and thin women with PCOS have a form of insulin resistance that is unique and intrinsic to the disorder. Moreover obese women with PCOS possess an additional burden of insulin resistance resulting from their excess adiposity. Hyperinsulinemia leads to increase in androgen production directly by acting as a co-gonadotropin, augmenting Luteinizing Hormone activity within the ovary, and indirectly by increasing serum LH pulse amplitude. Whereas Androgens may in turn contribute at least partially to the insulin resistance state linked with PCOS.  In this review, we will briefly study the role of insulin resistance in polycystic ovary syndrome. Keywords: Polycystic ovary syndrome, insulin resistance, Hyperandrogenism.

scholarly journals The clinical significance and primary determinants of hirsutism in patients with polycystic ovary syndrome

2013 ◽  
Vol 168 (6) ◽  
pp. 871-877 ◽  
Author(s):  
Dimitrios Panidis ◽  
Konstantinos Tziomalos ◽  
Efstathios Papadakis ◽  
Panagiotis Chatzis ◽  
Eleni A Kandaraki ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Polycystic Ovary Syndrome ◽  
Abdominal Obesity ◽  
Polycystic Ovary ◽  
Linear Regression Analysis ◽  
Serum Testosterone ◽  
Normal Weight ◽  
Binary Logistic Regression Analysis ◽  
Obese Women ◽  
Ovary Syndrome

ObjectiveHirsutism is frequently present in patients with polycystic ovary syndrome (PCOS) and is a major sign of hyperandrogenism. However, other disorders frequently present in PCOS, particularly abdominal obesity and insulin resistance (IR), have also been implicated in the development of hirsutism in this population but relevant data are limited. We aimed to define the determinants of the presence of hirsutism in PCOS.DesignObservational study.MethodsWe studied 1297 patients with PCOS (age 24.3±5.8 years, BMI 26.8±6.9 kg/m2). Hirsutism was defined as a modified Ferriman–Gallwey score ≥8.ResultsWomen with hirsutism were younger, had greater BMI, and had higher levels of circulating androgens than women without hirsutism; markers of IR did not differ between the two groups after adjustment for age and BMI. The prevalence of hirsutism progressively declined with age, was lower in normal-weight women than in overweight and obese women, and was comparably prevalent in the hyperandrogenemic phenotypes of PCOS. In binary logistic regression analysis, independent predictors of the presence of hirsutism were younger age, larger waist circumference (W), and higher serum testosterone levels. In stepwise linear regression analysis, the Ferriman–Gallwey score independently correlated with age, W, free androgen index, and serum Δ4-androstenedione and DHEAS levels.ConclusionsBesides hyperandrogenemia, abdominal obesity, and young age are independently associated with the presence of hirsutism. In contrast, the relationship between IR and hirsutism appears to be mediated by the more severe obesity of insulin-resistant patients with PCOS.

Hypothalamic-Pituitary-Adrenocortical Axis Hypersensitivity and Glucocorticoid Receptor Expression and Function in Women with Polycystic Ovary Syndrome

2011 ◽  
Vol 119 (10) ◽  
pp. 636-643 ◽  
Author(s):  
D.Vojnović Milutinović ◽  
D. Macut ◽  
I. Božić ◽  
J. Nestorov ◽  
S. Damjanović ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Glucocorticoid Receptor ◽  
Hpa Axis ◽  
Protein Concentration ◽  
Polycystic Ovary ◽  
Normal Weight ◽  
Receptor Expression ◽  
Obese Women ◽  
Ovary Syndrome ◽  
And Function

AbstractMolecular mechanisms underlying pathophysiology of polycystic ovary syndrome (PCOS), especially those related to cortisol signaling, are poorly understood. We hypothesized that modulation of glucocorticoid receptor (GR) expression and function, may underlie possible PCOS-related impairment of feedback inhibition of hypothalamic-pituitary-adrenocortical (HPA) axis activity and thus contribute to increased adrenal androgen production in women with PCOS.24 normal-weight and 31 obese women with PCOS were compared to 25 normal-weight controls. Fasting blood samples were collected for measurements of serum concentrations of dehydroepiandrosterone sulfate, testosterone, sex hormone-binding globulin, insulin, basal cortisol and cortisol after oral administration of 0.5 mg dexamethasone. Concentrations of GR mRNA, GR protein, mineralocorticoid receptor (MR) protein and heat shock proteins (Hsps), as well as the number of GR per cell (Bmax) and its equilibrium dissociation constant (KD) were measured in isolated peripheral blood mononuclear cells.An increase in HPA axis sensitivity to dexamethasone, an elevation of the GR protein concentration, and unaltered receptor functional status were found in both normal-weight and obese women with PCOS vs. healthy controls. Lymphocyte MR, Hsp90 and Hsp70 concentrations, and MR/GR ratio were similar in all groups. Correlation between Bmax and KD was weaker in the group of obese women with PCOS than in the other 2 groups.The results did not confirm the initial hypothesis, but imply that PCOS is associated with increased GR protein concentration and HPA axis sensitivity to dexamethasone.

Plasma omentin and adiponectin levels as markers of adipose tissue dysfunction in normal weight and obese women with polycystic ovary syndrome

2014 ◽  
Vol 81 (4) ◽  
pp. 529-535 ◽  
Author(s):  
Bartłomiej Orlik ◽  
Paweł Madej ◽  
Aleksander Owczarek ◽  
Piotr Skałba ◽  
Jerzy Chudek ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Normal Weight ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Adipose Tissue Dysfunction

scholarly journals Effects of metformin and ethinyl estradiol–cyproterone acetate on lipid levels in obese and non-obese women with polycystic ovary syndrome

2005 ◽  
Vol 152 (2) ◽  
pp. 269-275 ◽  
Author(s):  
K Rautio ◽  
J S Tapanainen ◽  
A Ruokonen ◽  
L C Morin-Papunen
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Ethinyl Estradiol ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Metformin Treatment ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Cholesterol Ratio

Objective: Women with polycystic ovary syndrome (PCOS) exhibit risk factors for cardiovascular diseases such as abdominal obesity, insulin resistance and dyslipidemia. Insulin sensitizers, especially metformin, have been shown to improve these metabolic disturbances, but there are only a few studies on their effects on serum lipids in polycystic ovary syndrome. Methods: Thirty-five women with PCOS (18 obese and 17 non-obese) were randomized to 6-month treatments with metformin or ethinyl estradiol–cyproterone acetate oral contraceptive pills. Results: In the whole-study population (non-obese and obese women) serum levels of high-density lipoprotein cholesterol increased from 1.4±0.2 to 1.6±0.1 mmol/l (means ±s.e. throughout) at 3 and 6 months (P < 0.001), the total cholesterol:high-density lipoprotein cholesterol ratio decreased significantly from 3.8±0.3 to 3.3±0.2 at 6 months (P < 0.001) and a similar trend was observed in serum triglyceride levels during metformin treatment. In the oral contraceptive group, serum levels of total cholesterol increased from 4.9±0.3 to 5.4±0.3 mmol/l (P < 0.05), high-density lipoprotein cholesterol increased from 1.2±0.1 to 1.5±0.1 mmol/l (P < 0.001), the total cholesterol:high-density lipoprotein cholesterol ratio decreased from 4.6±0.4 to 3.7±0.2 (P < 0.001) and triglycerides increased from 1.3±0.1 to 1.9±0.2 mmol/l at 6 months of treatment (P < 0.001). Serum low-density lipoprotein cholesterol levels remained unchanged during both treatments. Milder but similar changes in the subgroups of obese and non-obese women were observed during both treatments. Moreover, in the whole-study population both systolic (P = 0.02) and diastolic (P = 0.05) blood pressures decreased over the 6 months of metformin treatment. Conclusion: In women with PCOS, metformin treatment had beneficial effects on lipid profile and blood pressure, and therefore it could be useful in the prevention of cardiovascular complications in these women.

Serum levels of fibronectin in obese and non-obese women with polycystic ovary syndrome

2016 ◽  
Vol 62 (4) ◽  
pp. 27-31 ◽  
Author(s):  
Mogylnytska A. Liliya
Keyword(s):  
Endothelial Dysfunction ◽  
Serum Level ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Control Group ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Insulin Resistence ◽  
Relationship Of

Aim — to investigate serum level of fibronectin in obese and non-obese women with polycystic ovary syndrome (PCOS) as a marker of endothelial dysfunction, and the relationship of that factor to the endothelium-dependent dilatation and other risk factors for cardiovascular disease.Material and methods. We study 62 women: 45 — with PCOS (23 obese women, 22 — non-obese) and 20 — a control group. Serum level of fibronectin was determined by ELISA. Endothelium-dependent dilatation was measured by test of Celermajer. Data was presented as mean ± SD.Results. We found an elevation of serum level of fibronectin in obese women with PCOS compared to control (258,12±48,47 and 196,34±46,68 pmol/ml respectively; р<0,05), in non-obese women compared to control (227,62±35,36 and 196,34±46,68 pmol/ml respectively, р<0,05). Serum level of fibronectin in obese was higher than non-obese women (258,12±48,47 и 227,62±35,36 pmol/ml respectively, р<0,05). Also, there are a correlation between the serum levels of fibronectin and BMI, HOMA index, lipid metabolism, androgens in PCOS women obese and non-obese (p<0,05).Conclusion. Serum level of fibronectin is elevated in obese and non-obese women with PCOS. Hyperandrogenemia, dyslipidemia, insulin resistence, obesity appears to be significant factor to contributing elevation of fibronectin. The revealed change of fibronectin could reflect an endothelial dysfunction in PCOS.

Prevalence of metabolic syndrome in obese women with polycystic ovary syndrome

2014 ◽  
Author(s):  
Ivana Bozic Antic ◽  
Djuro Macut ◽  
Jelica Bjekic-Macut ◽  
Danijela Vojnovic Milutinovic ◽  
Milan Petakov ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Obese Women ◽  
Ovary Syndrome

High prevalence of multimorbidity in overweight and obese women with Polycystic Ovary Syndrome (PCOS)

2017 ◽  
Author(s):  
Hamidreza Mani ◽  
Yogini Chudasama ◽  
Danielle Bodicoat ◽  
Miles Levy ◽  
Laura Gray ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Obese Women ◽  
Ovary Syndrome ◽  
High Prevalence
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