scholarly journals Increased Nuclear Localization of β - catenin by rhBMP - 2 in the Induced Oral Squamous Cell Carcinoma in the Syrian Hamster Cheek Pouch

2018 ◽  
Vol 11 (3) ◽  
Author(s):  
Khaled Waleed Zaid ◽  
Jean Nassar ◽  
Mazen Doumani ◽  
Rashad Murad ◽  
Charif Barakat ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nuclear Localization ◽  
Squamous Cell ◽  
Syrian Hamster ◽  
Cheek Pouch ◽  
Hamster Cheek Pouch

scholarly journals DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Diana A. Martínez B. ◽  
Paola Andrea Barato Gómez ◽  
Carlos Arturo Iregui Castro ◽  
Jaiver E. Rosas Pérez
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Syrian Hamster ◽  
Mineral Oil ◽  
Carcinogenic Effect ◽  
Group A ◽  
Immunomodulatory Action ◽  
Group B

Objectives. To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. Materials and Methods. Two different experiments were performed. In the first experiment, hamsters’ right buccal pouches in group A (n = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (n = 4) were painted with mineral oil only. Two animals were sacrificed every three weeks to obtain histological samples and to evaluate pathological abnormalities. After 12 weeks of exposition and with no macroscopic evidence of neoplasms, dexamethasone DM (1 mg/kg) was administered daily for 7 days to the last two animals in the study. In the second experiment, DM was administered since DMBA exposition, following the same protocol as the first experiment. Results. The time of macroscopic neoplasm development was reduced when DM-DMBA coexposition was employed, finding tumors after 10–12 weeks of exposition. In addition, the frequency of histopathological lesions was higher. Conclusion. Immunomodulatory action of dexamethasone may reduce the time of oral squamous cell carcinoma (OSCC) induction and may increase the incidence of neoplasms developed.

Pulsed potassium-titanyl-phosphate laser photoangiolytic treatment of mucosal squamous cell carcinoma in the hamster cheek pouch

2011 ◽  
Vol 121 (5) ◽  
pp. 942-946 ◽  
Author(s):  
James A. Burns ◽  
Gerardo Lopez-Guerra ◽  
James B. Kobler ◽  
William Faquin ◽  
Matthew LeClair ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Potassium Titanyl Phosphate ◽  
Cheek Pouch ◽  
Hamster Cheek Pouch ◽  
Potassium Titanyl Phosphate Laser

Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma

2008 ◽  
Vol 97 (6) ◽  
pp. 544-550 ◽  
Author(s):  
Chiao-Ying Lin ◽  
Yung-Ming Jeng ◽  
Han-Yi Chou ◽  
Hey-Chi Hsu ◽  
Ray-Hwang Yuan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nuclear Localization ◽  
Squamous Cell ◽  
Annexin A1
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