scholarly journals Gallic Acid Inhibits Invasion and Reduces IL-6 Gene Expression, pSTAT3, pERK1/2, and pAKT Cellular Signaling Proteins in Human Prostate Cancer DU-145 Cells

2017 ◽  
Vol 10 (11) ◽  
Author(s):  
Esfandiar Heidarian ◽  
Mahnaz Keloushadi ◽  
Keihan Ghatreh-Samani ◽  
Effat Jafari-Dehkordi
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Gallic Acid ◽  
Cellular Signaling ◽  
Human Prostate ◽  
Signaling Proteins ◽  
Human Prostate Cancer

Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells

2011 ◽  
Vol 28 (10) ◽  
pp. 579-587 ◽  
Author(s):  
Kuo-Ching Liu ◽  
Heng-Chien Ho ◽  
An-Cheng Huang ◽  
Bin-Chuan Ji ◽  
Hui-Yi Lin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Dna Damage ◽  
Dna Repair ◽  
Gallic Acid ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Repair Gene ◽  
Dna Repair Gene

High Selenium Reduces NF-κB-Regulated Gene Expression in Uninduced Human Prostate Cancer Cells

2007 ◽  
Vol 58 (2) ◽  
pp. 197-204 ◽  
Author(s):  
Merrill J. Christensen ◽  
Edward T. Nartey ◽  
Aimee L. Hada ◽  
Russell L. Legg ◽  
Brett R. Barzee
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
High Selenium ◽  
Regulated Gene Expression

scholarly journals Identification and Characterization of Key Differentially Expressed Genes Associated With Metronomic Dosing of Topotecan in Human Prostate Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Taraswi Mitra Ghosh ◽  
Jason White ◽  
Joshua Davis ◽  
Suman Mazumder ◽  
Teeratas Kansom ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cell Lines ◽  
Differentially Expressed Genes ◽  
Expression Patterns ◽  
Differentially Expressed ◽  
Molecular Networks ◽  
Human Prostate ◽  
Mouse Tumor ◽  
Human Prostate Cancer

Repetitive, low-dose (metronomic; METRO) drug administration of some anticancer agents can overcome drug resistance and increase drug efficacy in many cancers, but the mechanisms are not understood fully. Previously, we showed that METRO dosing of topotecan (TOPO) is more effective than conventional (CONV) dosing in aggressive human prostate cancer (PCa) cell lines and in mouse tumor xenograft models. To gain mechanistic insights into METRO-TOPO activity, in this study we determined the effect of METRO- and CONV-TOPO treatment in a panel of human PCa cell lines representing castration-sensitive/resistant, androgen receptor (+/−), and those of different ethnicity on cell growth and gene expression. Differentially expressed genes (DEGs) were identified for METRO-TOPO therapy and compared to a PCa patient cohort and The Cancer Genome Atlas (TCGA) database. The top five DEGs were SERPINB5, CDKN1A, TNF, FOS, and ANGPT1. Ingenuity Pathway Analysis predicted several upstream regulators and identified top molecular networks associated with METRO dosing, including tumor suppression, anti-proliferation, angiogenesis, invasion, metastasis, and inflammation. Further, the top DEGs were associated with increase survival of PCa patients (TCGA database), as well as ethnic differences in gene expression patterns in patients and cell lines representing African Americans (AA) and European Americans (EA). Thus, we have identified candidate pharmacogenomic biomarkers and novel pathways associated with METRO-TOPO therapy that will serve as a foundation for further investigation and validation of METRO-TOPO as a novel treatment option for prostate cancers.

141: Gene Expression in Response to High-Fat Feeding in Human Prostate Cancer Xenograft Model

2007 ◽  
Vol 177 (4S) ◽  
pp. 48-48
Author(s):  
Shintaro Narita ◽  
Norihiko Tsuchiya ◽  
Mitsuru Saito ◽  
Takamitsu Inoue ◽  
Teruaki Kumazawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Xenograft Model ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
High Fat ◽  
Fat Feeding

scholarly journals Alteration of glyoxalases gene expression in response to testosterone in LNCaP and PC3 human prostate cancer cells

2007 ◽  
Vol 6 (12) ◽  
pp. 1880-1888 ◽  
Author(s):  
Cinzia Antognelli ◽  
Chiara Del Buono ◽  
Francesca Baldracchini ◽  
Vincenzo Talesa ◽  
Emanuele Cottini ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells

The Prostate ◽  
2009 ◽  
Vol 69 (2) ◽  
pp. 181-190 ◽  
Author(s):  
Suvarna Bhamre ◽  
Debashis Sahoo ◽  
Robert Tibshirani ◽  
David L. Dill ◽  
James D. Brooks
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Cells ◽  
Temporal Changes ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells
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