De-Novo Autoimmune Hepatitis with Consecutive Acute Liver Failure Induced by Hepatitis E Infection: A Case Report

2017 ◽  
Vol 17 (3) ◽  
Author(s):  
Victoria Thodou ◽  
Matthias Buechter ◽  
Ali Canbay ◽  
Hideo A. Baba ◽  
Julia Kalsch ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Autoimmune Hepatitis ◽  
De Novo ◽  
Hepatitis E

scholarly journals Crossroad of infection and autoimmunity in acute liver failure: a case report

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Akash Roy ◽  
Sunil Taneja ◽  
Arka De ◽  
Ashim Das ◽  
Ajay K. Duseja ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Autoimmune Hepatitis ◽  
De Novo ◽  
Dramatic Improvement ◽  
Case Presentation ◽  
Wide Range ◽  
Syndromic Diagnosis ◽  
Initial Improvement ◽  
Tropical Infections

Abstract Background Acute liver failure (ALF) is a syndromic diagnosis, consisting of jaundice, coagulopathy, and any degree of encephalopathy in a patient without pre-existing liver disease within 26 weeks of the onset of symptoms. Autoimmune hepatitis has a wide range of presentations and can rarely present as ALF, which frequently tends to be autoantibody negative. Tropical infections like dengue, malaria, and leptospirosis, which present as mimickers of ALF, always remain a differential diagnosis of ALF and mandate an etiology specific management. In rare cases, such infections themselves act as a trigger for autoimmunity. We report a case of diagnostic crossroads of infection and autoimmunity, presenting as acute liver failure and describe the challenges in management. Case presentation A 25-year-old female presented with a syndromic diagnosis of acute liver failure with possibility of tropical illness-related ALF mimic on account of positive Leptospira serology. After initial improvement, there was a rebound worsening of liver functions which prompted a liver biopsy. Biopsy narrowed the differential to Leptospira-associated hepatitis and severe auto-immune hepatitis. Trial of low dose steroid was given which led to dramatic improvement. Conclusion Tropical infections can present as ALF mimics and can themselves act as triggers for autoimmunity. Distinguishing such cases from de-novo acute severe autoimmune hepatitis is difficult and requires therapeutic brinksmanship. An early trial of steroid is mandated but comes with its own challenges.

scholarly journals A Case Report of Hepatitis E Infection Leading to Acute Liver Failure and Transplantation

2008 ◽  
Vol 1 ◽  
pp. CCRep.S845
Author(s):  
P. Paskaran ◽  
A.U. Murugananthan ◽  
V. Manglam ◽  
J. Arnold ◽  
A. Pal
Keyword(s):  
Case Report ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis E

scholarly journals Lethal biliary congestive acute hepatitis E without acute liver failure: A case report

Kanzo ◽  
2021 ◽  
Vol 62 (8) ◽  
pp. 463-470
Author(s):  
Nao Yamauchi ◽  
Tetsuya Yasunaka ◽  
Akinobu Takaki ◽  
Yoshimune Hinami ◽  
Masaru Kinomura ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Acute Hepatitis ◽  
Hepatitis E ◽  
Acute Hepatitis E

scholarly journals Dirofilaria repens in a cat with acute liver failure : case report

2000 ◽  
Vol 71 (3) ◽  
Author(s):  
E.V. Schwan ◽  
D.B. Miller ◽  
D. De Kock ◽  
A. Van Heerden
Keyword(s):  
South Africa ◽  
Case Report ◽  
Acid Phosphatase ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Dirofilaria Immitis ◽  
Dirofilaria Repens ◽  
Fine Needle Aspirate ◽  
Fine Needle ◽  
Antigen Capture

Acute liver failure was diagnosed in a 12-year-old cat. Fine needle aspirate cytology revealed high numbers of unsheathed microfilariae and a hepatocellular reaction with no evidence of bacterial infection. The microfilariae were identified as those of Dirofilaria repens by acid phosphatase staining. The high number of microfilariae seen in both the blood and the liver aspirate samples as well as the favourable response to ivermectin amongst other drugs administered, is suggestive that D. repens was the cause of the liver insult. A positive result obtained with an antigen-capture ELISA (Dirochek (r)) for Dirofilaria immitis antigen was interpreted as false. This is the 1st report of Dirofilaria repens for South Africa.

Sign in / Sign up

Export Citation Format

Share Document