scholarly journals Apolipoprotein C3 Gene Polymorphisms Are Not a Risk Factor for Developing Non-Alcoholic Fatty Liver Disease: A Meta-Analysis

2014 ◽  
Vol 14 (10) ◽  
Author(s):  
Haiying Zhang ◽  
Lizhen Chen ◽  
Yongning Xin ◽  
Yuangui Lou ◽  
Yang Liu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Alcoholic Fatty Liver ◽  
Apolipoprotein C3 ◽  
C3 Gene ◽  
Alcoholic Fatty Liver Disease

Non-Alcoholic Fatty Liver Disease as a Risk Factor for Cholangiocarcinoma: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 152 (5) ◽  
pp. S1042
Author(s):  
Nicha Wongjarupong ◽  
Buravej Assavapongpaiboon ◽  
Paweena Susantitaphong ◽  
Sombat Treeprasertsuk ◽  
Rungsun Rerknimitr ◽  
...  
Keyword(s):  
Systematic Review ◽  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Association of apolipoprotein C3 polymorphisms with non-alcoholic fatty liver disease: an updated meta-analysis

2020 ◽  
Author(s):  
Yu-Kang Chang ◽  
Kuan-Chun Hsueh ◽  
Chia-Hung Liu ◽  
Yen-Li Lo ◽  
Yang-Sheng Lin ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Promoter Region ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Caucasian Population ◽  
Alcoholic Fatty Liver ◽  
Apolipoprotein C3 ◽  
Functional Polymorphisms ◽  
Alcoholic Fatty Liver Disease

Abstract Background The relationships between gene polymorphisms of apolipoprotein C3 (APOC3) and risk of non-alcoholic fatty liver disease (NAFLD) have been investigated, however, their findings were inconclusive. The aim of this meta-analysis is to evaluate the effects of APOC3 promoter region polymorphisms (-455T/C and − 482C/T) on the susceptibility to NAFLD. Methods A comprehensive literature search was carried out with electronic databases including MEDLINE, EMBASE, Web of Science, and Google Scholar to identify eligible studies up to June 2019. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the combined effect sizes. The level of heterogeneity, sensitivity, subgroup, and publication bias analyses were subsequently conducted. Results This meta-analysis included seven studies, containing 1,318 NAFLD cases and 1,691 controls fulfilling the inclusion and exclusion criteria. The pooled analysis showed significant associations between APOC3 -455T/C polymorphism and risk of NAFLD in allelic model (OR = 1.33) and recessive model (OR = 1.67), but not in the dominant model. When stratified by ethnicity, the polymorphism − 455T/C was found to be significantly associated with risk of NAFLD in the Caucasian population, but not in the Asian population. No association was evident between the polymorphism − 482C/T and risk of NAFLD. Conclusions Our findings suggest that APOC3 promoter region polymorphism − 455T/C may associate with risk of NAFLD in Caucasian population. Further studies with other functional polymorphisms are helpful to discover the effects of APOC3 gene on the development of NAFLD.

scholarly journals A PRISMA-compliant meta-analysis of apolipoprotein C3 polymorphisms and non-alcoholic fatty liver disease

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Bing-Feng Chen ◽  
Yeuh Chien ◽  
Pin-Hsing Tsai ◽  
Pang-Chung Perng ◽  
Yi-Ping Yang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Alcoholic Fatty Liver ◽  
Apolipoprotein C3 ◽  
Alcoholic Fatty Liver Disease

scholarly journals Association between APOC3 polymorphisms and non-alcoholic fatty liver disease risk: a meta-analysis

2020 ◽  
Vol 20 (4) ◽  
pp. 1800-8
Author(s):  
Jun Wang ◽  
Chuncui Ye ◽  
Sujuan Fei
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Disease Risk ◽  
Meta Analysis ◽  
Group Analysis ◽  
Alcoholic Fatty Liver ◽  
Apolipoprotein C3 ◽  
Apoc3 Gene ◽  
Alcoholic Fatty Liver Disease

Background and Aim: The apolipoprotein C3 (APOC3) polymorphism has been reported to predispose to non-alcoholic fatty liver disease (NAFLD). However, the results remain inconclusive. This meta-analysis aimed to provide insights into the association between APOC3 polymorphisms and NAFLD risk. Methods: Studies with terms “NALFD” and “APOC3” were retrieved from PubMed, Web of Science, CNKI and Wan- fang databases up to August 1, 2019. Pooled odds ratio (OR) and 95% confidence interval (95% CI) for the association of APOC3 polymorphisms and NAFLD risk were calculated using fixed and random-effects models. Results: A total of twelve studies from eleven articles were included. Of them, eight studies (1750 cases and 2181 controls) reported the strong association of variant rs2854116 with NAFLD and six studies (1523 cases and 1568 controls) found the association of rs2854117 polymorphism with NAFLD. Overall, a statistically significant association between rs2854116 pol- ymorphism of APOC3 gene and NAFLD risk was found only under dominant model. However, association of rs2854117 polymorphism with NAFLD risk was not detected under all four genetic models. In sub-group analysis of NAFLD subjects based on country, no association among them in China was detected. Besides, four studies analyze the association between the two polymorphisms and clinical characteristics in all subjects or NAFLD patients, and we also failed detect any associa- tion between the wild carriers and variant carriers. Conclusion: The meta-analyses suggests that the rs2854116 polymorphism but not rs2854117 polymorphism in APOC3 gene might be a risk factor for NAFLD among Asians. That is, individuals with CT+CC genotype have higher risk of devel- oping NAFLD. However, studies with sufficient sample size are needed for the further validation. Keywords: Apolipoprotein C3; polymorphism; non-alcoholic fatty liver disease; meta-analysis.

scholarly journals Non-alcoholic fatty liver disease as a risk factor for cholangiocarcinoma: a systematic review and meta-analysis

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Nicha Wongjarupong ◽  
Buravej Assavapongpaiboon ◽  
Paweena Susantitaphong ◽  
Wisit Cheungpasitporn ◽  
Sombat Treeprasertsuk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Relationship between Muscle Mass and Non-Alcoholic Fatty Liver Disease

Biology ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 122
Author(s):  
Jun-Hyuk Lee ◽  
Hye-Sun Lee ◽  
Byoung-Kwon Lee ◽  
Yu-Jin Kwon ◽  
Ji-Won Lee
Keyword(s):  
Skeletal Muscle ◽  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Muscle Mass ◽  
Fatty Liver Disease ◽  
Skeletal Muscle Mass ◽  
Liver Fat ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Although sarcopenia is known to be a risk factor for non-alcoholic fatty liver disease (NAFLD), whether NAFLD is a risk factor for the development of sarcopenia is not clear. We investigated relationships between NAFLD and low skeletal muscle mass index (LSMI) using three different datasets. Participants were classified into LSMI and normal groups. LSMI was defined as a body mass index (BMI)-adjusted appendicular skeletal muscle mass <0.789 in men and <0.512 in women or as the sex-specific lowest quintile of BMI-adjusted total skeletal muscle mass. NAFLD was determined according to NAFLD liver fat score or abdominal ultrasonography. The NAFLD groups showed a higher hazard ratios (HRs) with 95% confidence intervals (CIs) for LSMI than the normal groups (HRs = 1.21, 95% CIs = 1.05–1.40). The LSMI groups also showed a higher HRs with 95% CIs for NAFLD than normal groups (HRs = 1.56, 95% CIs = 1.38–1.78). Participants with NAFLD had consistently less skeletal muscle mass over 12 years of follow-up. In conclusion, LSMI and NAFLD showed a relationship. Maintaining muscle mass should be emphasized in the management of NAFLD.

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