scholarly journals Anthracycline-Induced Cardiothoxicity in Children Cancer Patients: An Imaging Study by Two-Dimensional Global Longitudinal Strain Using Automated Function Imaging Technique

2018 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Chehreh Mahdavi ◽  
Ali-Asghar Zeinaloo ◽  
Azin Ghamari ◽  
Ehsan Aghaei Moghadam ◽  
Armen Kocharian ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Longitudinal Strain ◽  
Imaging Technique ◽  
Global Longitudinal Strain ◽  
Imaging Study ◽  
Two Dimensional

Immediate evaluation of global longitudinal strain at initiation of trastuzumab treatment in breast cancer patients

2021 ◽  
Author(s):  
Ann Banke ◽  
Morten Schou ◽  
Marianne Ewertz ◽  
Jordi Dahl ◽  
Peter Hartmund Frederiksen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Breast Cancer Patients ◽  
Trastuzumab Treatment

scholarly journals New capabilities in assessing the left ventricular contractility by two-dimensional speckle tracking echocardiography

2020 ◽  
Vol 35 (3) ◽  
pp. 79-85
Author(s):  
V. E. Oleynikov ◽  
Yu. G. Smirnov ◽  
V. A. Galimskaya ◽  
E. A. Gundarev ◽  
N. V. Burko
Keyword(s):  
Speckle Tracking ◽  
Longitudinal Strain ◽  
Speckle Tracking Echocardiography ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Cardiac Resynchronization ◽  
Two Dimensional ◽  
Ventricular Contractility ◽  
Resynchronization Therapy ◽  
Clinical Implementation

This work reviews the reasons why the characteristics of left ventricular (LV) contractility, in particular, and 2D speckle echocardiography-based peak rates of global longitudinal strain (GLS), are not widely used in clinical practice. Authors present the analysis of new indicators proposed for the assessment ofLVcontractile function based on longitudinal strain taking into account the involvement of individual segments. The authors show that the assessment of myocardial work indicators characterizing the relationships between contractile and pump functions is a promising approach for the study ofLVcontractile function. The analysis of postsystolic strain index (PSI) is presented to illustrate its clinical implementation in the studies of viable myocardium in ischemic conditions and evaluating the effectiveness of cardiac resynchronization therapy (CRT).

scholarly journals P1278 Budget impact of global longitudinal strain for the early detection of cardiotoxicity incorporation in the brazilian private healthcare system

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Miglioranza ◽  
R C Lucchetta ◽  
J L Barros Pena ◽  
J M Castillo ◽  
W P Oliveira Jr ◽  
...  
Keyword(s):  
Heart Failure ◽  
Early Detection ◽  
Cancer Patients ◽  
Healthcare System ◽  
Longitudinal Strain ◽  
Budget Impact ◽  
Global Longitudinal Strain ◽  
Private Healthcare ◽  
Eligible Population ◽  
Increased Risk

Abstract Funding Acknowledgements Department of Cardiovascular Imaging / Brazilian Society of Cardiology Objective To estimate the budget impact of incorporating global longitudinal strain (GLS) for the early detection of cardiotoxicity in patients under cancer treatment, compared to conventional echocardiographic measurements (ECO) in the Brazilian Private Healthcare System (PHS). Methods: The BI was calculated based on a Markov constructed with the following health states: no changes, cardiotoxicity, heart failure, reversibility and death, with annual cycles. Eligible population was estimated through an epidemiological approach, based on the prevalence of cancer, proportion of cancer patients treated with anthracyclines and proportion of patients covered by health plans. The time horizon was 5 years, with perspective of the PHS. One scenario was built considering only the cost of GLS and ECO, whereas the other scenario included direct medical costs related to the management of cardiotoxicity and heart failure. Probabilistic sensitivity analyses were performed to explore uncertainties. Results: The initial eligible population was estimated in 209,657 patients. The scenario considering only GLS and ECO procedures costs resulted in a positive BI, from BRL3.6 million in the first year to R$ 59 million in the fifth year. Considering total costs, the incorporation of GLS has the potential to result in savings to PHS from the fourth year of incorporation. In the fifth year the economy reaches about R$ 9 million. Deterministic results are corroborated by the probabilistic analyses. Conclusion: Cardiotoxicity has a major impact in cancer patients treated with anthracyclines, being associated with increased risk of heart failure and mortality. Since GLS has the potential of early detection of cardiotoxicity, allowing the rapid onset of treatment, the use of GLS has the potential to promote savings for the private healthcare system. Abstract P1278 Figure. budget impact of GLS

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