scholarly journals Effects of Exercise on Memory Consolidation and Retrieval of Passive Avoidance Learning In Young Male Rats

2010 ◽  
Vol 1 (3) ◽  
Author(s):  
Hakimeh Saadati ◽  
Shirin Babri ◽  
Naser Ahmadiasl ◽  
Mohammad Mashhadi
Keyword(s):  
Passive Avoidance ◽  
Memory Consolidation ◽  
Avoidance Learning ◽  
Young Male ◽  
Passive Avoidance Learning ◽  
Male Rats

scholarly journals Effect of a hydro-alcoholic extract of Melissa officinalis on passive avoidance learning and memory

2019 ◽  
Vol 8 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Zahra Dehbani ◽  
Alireza Komaki ◽  
Farshid Etaee ◽  
Siamak Shahidi ◽  
Masoumeh Taheri ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Learning And Memory ◽  
Avoidance Learning ◽  
Saline Group ◽  
Passive Avoidance Learning ◽  
Male Rats ◽  
Control Group ◽  
Alcoholic Extract ◽  
Melissa Officinalis ◽  
Significant Difference

Introduction: Melissa officinalis (MO) or lemon balm is traditionally used as a sedative and anti-spasm herbal medicine. There is also evidence that this plant has effects on learning and memory. This study examined the effect of a hydro-alcoholic extract of MO on passive avoidance learning (PAL) and memory in male rats. Methods: A total of 40 adult male Wistar rats were randomly distributed into four groups (200 to 220 g; n = 10 per group); three dose groups (50, 100, and 200 mg/kg of the hydro-alcoholic extract of MO) and vehicle control (saline) group. Saline or doses of extract were administered daily for 14 days by oral gavage. The rats were trained to enter the shuttle box to record their behavior in the PAL task. A retrieval test was performed 24 hours following training. Results: A significant difference was seen in performance among MO groups and the control. MO administered animals had a decreased number of acquisition trials (P < 0.05). In the retention task, MO administered animals had an increased step-through latency (SLT) (P < 0.01), and a decreased latency in the dark compartment (P < 0.001) compared to the control group. Conclusion: The results of the study show that MO can improve learning and memory in the PAL task. Further investigation is needed to enhance our understanding of the neurobiological mechanisms of the MO extract and its effects on learning and memory.

scholarly journals Nandrolone administration abolishes hippocampal fEPSP-PS potentiation and passive avoidance learning of adolescent male rats

2019 ◽  
Vol 97 (2) ◽  
pp. 130-139 ◽  
Author(s):  
Fatemeh Zarei ◽  
Farshad Moradpour ◽  
Ahmad Ali Moazedi ◽  
Ali Pourmotabbed ◽  
Mozhgan Veisi
Keyword(s):  
Synaptic Plasticity ◽  
Passive Avoidance ◽  
Avoidance Learning ◽  
Serum Levels ◽  
Acute Effect ◽  
Passive Avoidance Learning ◽  
Male Rats ◽  
Adolescent Male ◽  
Excitatory Postsynaptic Potential ◽  
Postsynaptic Potential

Despite the chronic effects of nandrolone decanoate (ND), the acute effects of ND on passive avoidance learning (PAL) and memory and its mechanism have not been investigated. This research examines the acute effect of ND on PAL, CA1 synaptic plasticity, testosterone and corticosterone serum levels, and the role of androgenic receptors (ARs). Adolescent male rats were treated with ND, 30 min before training and retention and after training test. AR antagonist was applied 15 min before ND. Hippocampal slices were perfused by ND. ND administration had an inverted U-shape effect on acquisition of PAL and on testosterone and corticosterone serum levels. The consolidation was only affected by high dose of ND. ND significantly decreased the retention of PAL across all doses. The magnitude of field excitatory postsynaptic potential long term potentiation was lower than that of control slices. In addition, an attenuation of field excitatory postsynaptic potential population spike coupling was also observed. Nilutamide could nullify the ND impairment effect. We concluded although a single dose of ND could affect all stages of PAL, its effects were more potent on retrieval, possibly arising from the acute effect of ND on the alterations of CA1 synaptic plasticity. In addition, ND may induce its effects directly through ARs and indirectly through plasma testosterone and corticosterone.

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