scholarly journals Accelerating Effects of Vitamin E Supplementation on Liver Enzyme Normalization in Children with Acute Hepatitis A Infection; a Single-Blinded Clinical Trial

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Iraj Shahramian ◽  
Kaveh Tabrizian ◽  
Mahdi Afshari ◽  
Ali Bazi ◽  
Elaheh Bahmadisani
Keyword(s):  
Clinical Trial ◽  
Vitamin E ◽  
Acute Hepatitis ◽  
Liver Enzyme ◽  
Hepatitis A ◽  
Post Treatment ◽  
Control Groups ◽  
Significant Difference ◽  
Acute Hepatitis A ◽  
And Control

Background: Hepatitis A virus (HAV) infection is a widespread disease with no specific treatment. Objectives: In the present study, we investigated the effects of vitamin E in the treatment of acute HAV infection in children. Methods: This clinical trial study was conducted on 142 patients with acute HAV infection referred to Amir-Al-Momenin Hospital of Zabol during February 2016-August 2017. The patients were randomly divided into two groups of intervention (Vit E, n = 71) and control (no medication, n = 71). Liver enzymes were monitored during a six-month period. Results: The mean ages of the patients were 8.4 ± 2.5 and 9 ± 4.3 years in the control and intervention groups, respectively. Male participants constituted 36 (50.7%) and 35 (49.3%) in the control and intervention groups, respectively. In both the treatment and control groups, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) significantly decreased over six months during the study (P < 0.001). AST level (IU/L) was significantly lower in the children who received vitamin E than controls at one-month (P = 0.01), two-month (P = 0.002), three-month (P = 0.005), four-month (P < 0.001), and six-month (P = 0.002) post-treatment periods. There was no significant difference comparing ALT between the intervention and control groups except for two months post-treatment (P = 0.01). Conclusions: Our study showed that the administration of vitamin E in children with acute hepatitis A can accelerate liver enzyme normalization.

scholarly journals Effectiveness of a Need-Based Program in Relieving Psychological Distress of Family Caregivers of Leukemia Patients: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Mehrdad Abdullahzadeh ◽  
Narjes Khosravi
Keyword(s):  
Clinical Trial ◽  
Psychological Distress ◽  
Family Caregivers ◽  
Psychological Needs ◽  
Anxiety And Depression ◽  
Study Group ◽  
Control Groups ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Abstract PurposeThe family of leukemia patients, due to their caring role, often feel psychological distress. This paper describes the efficacy of a designed family-need-based program on relieving depression, anxiety, and stress of family caregivers of leukemia patients by meeting the specific psychological needs of caregivers.MethodsIn this clinical trial, 64 family caregivers of leukemia patients referring to a medical center in Iran were recruited by convenience sampling and divided into study and control groups randomly. The study group attended a designed need-based program. The control group did not receive the intervention. Stress, anxiety, and depression before, right after, and one month after the intervention in family caregivers were compared using DASS-42. Data were analyzed using descriptive and inferential statistics; the significance level adopted was 5%.ResultsBefore the intervention, the mean score of depression, anxiety, and stress scale in both study and control groups showed no considerable difference (P > 0.05). After the intervention, the mean score of DASS-42 revealed a significant difference between the two groups and the study group did better on outcomes (P < 0.001).ConclusionThis family-need-based program can decrease the level of stress, anxiety, and depression of the family caregivers of leukemia patients and may potentially alleviate the psychological distress of family caregivers over their caring role.Trial registration number: IRCT2013093011895N2. Date of registration: 2014-05-06

scholarly journals The effect of delivery ball and warm shower on the childbirth experience of nulliparous women: A randomized controlled clinical trial

2021 ◽  
Author(s):  
parvaneh sharifipour ◽  
Masoomeh Kheirkhah ◽  
Mojgan Rajati ◽  
hamid haghani
Keyword(s):  
Clinical Trial ◽  
Pregnant Women ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Control Groups ◽  
Childbirth Experience ◽  
Nulliparous Women ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Abstract Background Childbirth is a unique experience that affects women’s life. Therefore, this study was performed to determine the effect of delivery ball and warm shower on the childbirth experience of primiparous women. Methods This study is a clinical trial that was carried out on primiparous pregnant women referred to Motazedi Hospital in Kermanshah, Iran. Sampling was done by continuous method and pregnant women were divided into three groups of delivery ball-warm shower (n = 33), delivery ball (n = 33) and control (n = 33). Exercise with ball at the dilation of 4 cm was similar in the two groups of delivery ball-warm shower and delivery ball, but the first group also used warm shower at the dilatation of 7 cm. The control group only received the routine delivery care. Demographic information form consisting of pregnancy history and information about the mother and infant were completed and the childbirth experience questionnaire (CEQ) were completed by the women two hours after the childbirth. Results There was a statistically significant difference in the mean score of childbirth experience after the intervention between the two groups of delivery ball-warm shower and control (P = 0.001), and also between the delivery ball and control groups (P = 0.001). There was a statistically significant difference in the mean scores of professional support between the two groups of delivery ball-warm shower and control (P = 0.02) and also between the delivery ball and control groups (p = 0.02). There was a statistically significant difference in the mean scores of participation between the two groups of delivery ball-warm shower and control (P = 0.003) and also between the delivery ball and control groups (P = 0.01). There was also a statistically significant difference in the mean scores of sense of security between the two groups of delivery ball-warm shower and control (P = 0.01). Conclusion Delivery ball and warm shower were effective interventions to create a positive childbirth experience. This method was more effective than using delivery ball alone in childbirth experience. To achieve a positive experience of childbirth in mothers, the use of both intervention (delivery ball and warm shower) is recommended.

scholarly journals Evaluation of Dorema Ammoniacum and Acupuncture's Therapeutic Effects in Patients With Ischemic Stroke: A Randomized Controlled Clinical Trial 

2020 ◽  
Author(s):  
Mahsa Mehrpour ◽  
Mahdi Yousefi ◽  
Monavar AfzalAghaee ◽  
Hasan Rakhshandeh ◽  
Hoda Azizi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Ischemic Stroke ◽  
Acupuncture Group ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Control Groups ◽  
Randomized Controlled ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Abstract Aim: Stroke is the third prevalent cause of disability worldwide. This study aimed to evaluate the role of Dorema ammoniacum and acupuncture in the management of patients with stroke.Methods: In this randomized controlled clinical trial, patients with a recent ischemic stroke (within the first month of stroke) were investigated. The patients were divided into three groups. The first group was managed by acupuncture, while the second group received 1 g of Dorema ammoniacum (two 500 mg capsules per day) from ammoniacum gum. The two intervention groups also received standard treatment with routine medical therapy and physiotherapy. The final group was the control, which only received conventional treatment and physiotherapy. The patients were evaluated immediately before the interventions, and one month after the interventions, using the Modified Rankin Scale (mRS) and Modified National Institutes of Health Stroke Scale (mNIHSS).Results: There was a significant difference in the mean score of mNIHSS at the beginning and end of the study in all of the three studied groups (P<0.001). There were significant pre-treatment/post-treatment differences between the groups (P<0.001). After controlling for the effect of mNIHSS score at the beginning of the study and the follow-up visit, a significant difference was observed between the three groups regarding the mean mNIHSS score post-intervention (P<0.001). The results of the post-hoc test indicated a significant difference between the acupuncture and control groups, Dorema ammoniacum and control groups (P<0.001), acupuncture, and Dorema ammoniacum groups (P<0.001); the extent of reduction was greater in the acupuncture group. The mean mNIHSS scores of the acupuncture and Dorema ammoniacum groups were 1.82 and 1.04 lower than the control group's mean score, respectively. There was a significant difference in the mean mRS score at the beginning and end of the study in all three groups (P<0.001). However, the extent of reduction was greater in the acupuncture group.Conclusion: Acupuncture and Dorema ammoniacum may be beneficial if started within the first month of stroke incidence. However, acupuncture can cause a greater reduction in the mNIHSS score of stroke patients. Trial registration: Iranian Registry of Clinical Trials (IRCT20170227032797N2).Registered 5 March 2018 - Retrospectively registered, https://www.irct.ir/trial/25469

scholarly journals The effect of vitamin D therapy on glycemic control and biochemical indices in type 2 diabetic patients: a randomized, clinical trial study

2021 ◽  
Vol 25 (2) ◽  
pp. 125-133
Author(s):  
Majid Mozaffari ◽  
◽  
Hamed Hajmoradi ◽  
Alireza Moravveji ◽  
Fatemeh Sadat Asgarian ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Vitamin D ◽  
Glycemic Control ◽  
Control Groups ◽  
Significant Difference ◽  
The Mean ◽  
Biochemical Indices ◽  
And Control

Introduction: The aim of the present study was to evaluate the effect of vitamin D on glycemic control and biochemical indices in type 2 diabetes. Methods: This randomized double blind placebo-controlled clinical trial was conducted on 80 patients with type 2 diabetes mellitus (T2DM) referred to Shahid Beheshti hospital. These patients were randomly classified into case and control groups. Case group consumed 50,000 IU of vitamin D once a week for 12 weeks and control group placebo. Biochemical and lipid parameters and vitamin D3 were measured in two groups. Glycosylated hemoglobin (HbA1c) was assessed by latex enhance immunoturbidimetric assay. Results: There was no significant difference between case and control groups in terms of age, sex, body mass index and used medications. The mean vitamin D level in case and control groups before intervention was 15.06 ±3.307 and 15.83± 2.509 ng/ml and after intervention was 49.77 ±15.73 and 14.91±3.13 ng/ml respectively. The mean fast blood sugar in case and control groups after intervention was 156.565±32.23 and 147.75±35.06 mg/dl, respectively. The mean HbA1c in case and control groups before intervention was 7.59± 0.39 % and 7.66± 0.38 % and after intervention was 7.26 ± 0.60 and 7.60 ± 0.38, respectively. Moreover, significant difference was seen between case (20.2± 5.74 IU/L) and control groups (23.35± 7.80 IU/L) in terms of alanine aminotransferase, after intervention. Conclusion: According to these findings, vitamin D supplementation possibly through decreasing HbA1C and hepatic alanine aminotransferase could improve diabetes complications.

scholarly journals Effect of Home Nursing Care on the Severity of Symptoms in Patients With Bipolar I Disorder: A Randomized Clinical Trial

2020 ◽  
pp. 108482232096912
Author(s):  
Reza Zeighami ◽  
Arghavan Raeisolhagh ◽  
Mehdi Ranjbaran
Keyword(s):  
Clinical Trial ◽  
Nursing Care ◽  
T Test ◽  
Home Nursing ◽  
Control Groups ◽  
Bipolar I Disorder ◽  
Significant Difference ◽  
Severity Of The Disease ◽  
Home Nursing Care ◽  
And Control

Bipolar I disorder is a common, chronic, and recurrent disease in which improper and inadequate follow-up of patients after discharge leads to increased hospitalization. This study aimed at investigating the effect of home nursing care on the severity of symptoms of bipolar I disorder. This clinical trial was performed on 90 patients admitted to 22 Bahman Qazvin Hospital in 2019. The available sampling was done using random allocation of six blocks in experimental and control groups. In the experimental group, after leaving the hospital, the intervention was performed for 3 months in the form of two telephone calls and one face-to-face meeting per month. Data were collected using a demographic questionnaire, the Yang scale questionnaire, and entered into the SPSS-24 software. Statistical tests such as Mann-Whitney u test, Fisher, independent T-test, paired T-test, chi-square, and ANCOVA were used at the significance level of p < .05. The severity of the disease before the intervention in the experimental and control groups were (93/9 ± 25/32) and (04/11 ± 86/28), respectively, showing no statistically significant difference ( p = .146). However, after the intervention, the mean severity of the disease in the experimental and control groups were (17/5 ± 38/13) and (79/12 ± 21/33), respectively, showing a statistically significant difference ( p < .05). According to the results, the home nursing care for patients leads to a reduction in the severity of symptoms and a reduction in the rate of re-hospitalization of patients.

scholarly journals The Effect of Auriculotherapy on Pulmonary Findings and Sleep Quality in Patients with Covid 19

2021 ◽  
Author(s):  
Maryam Mohammadi ◽  
Zohreh AkhoundiMeybodi ◽  
Mahboubeh Valiani ◽  
Mohammad Sharifyazdi ◽  
Leila Asadi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Electrical Stimulation ◽  
Sleep Quality ◽  
Demographic Characteristics ◽  
Time Data ◽  
Control Groups ◽  
Significant Difference ◽  
Before And After ◽  
The Mean ◽  
And Control

Abstract Background: Auriculotherapy is a sub-branch of acupuncture and is an effective method in acute and chronic diseases. Aim: The aim of this study was to evaluate the effect of Auriculotherapy on pulmonary findings and sleep quality in patients with Covid 19.Methods: The present study is a clinical trial study in which 70 hospitalized patients with Covid 19 with pulmonary findings and low sleep quality were randomly divided into intervention and control groups. Auriculotherapy was performed with electrical stimulation in one session and then Vakaria seed was placed in acupressure points and stimulated for one week (8 times a day for one minute each time). Data collection tools were checklist of pulmonary findings, Pittsburgh questionnaires and demographic characteristics.Results: The results showed that there was no significant difference between the mean SPO2 score in the two groups before and after the intervention (P = 0.09). There was a statistically significant difference between the mean score of dyspnea (P = 0.003), cough (P <0.008) and overall score of sleep quality in the two groups before and after the intervention (P <0.001).Conclusion: The results of this study showed that Auriculotherapy is effective on pulmonary improvements and sleep quality in patients with Covid 19.Trial registration: IRCT, IRCT20180608040007N2. Registered 13 June 2020, https://en.irct.ir/trial/48218.

scholarly journals Alleviating Effects of Ursodeoxycholic Acid in Children with Acute Hepatitis A Infection: A Randomized Clinical Trial

2019 ◽  
Vol 19 (7) ◽  
Author(s):  
Kaveh Tabrizian ◽  
Iraj Shahramian ◽  
Ali Bazi ◽  
Mahdi Afshari ◽  
Asma Ghaemi
Keyword(s):  
Clinical Trial ◽  
Acute Hepatitis ◽  
Ursodeoxycholic Acid ◽  
Randomized Clinical Trial ◽  
Hepatitis A ◽  
Acute Hepatitis A

Sources of Infection Among Persons With Acute Hepatitis A and No Identified Risk Factors During a Sustained Community-Wide Outbreak

PEDIATRICS ◽  
2000 ◽  
Vol 106 (4) ◽  
pp. e54-e54 ◽  
Author(s):  
C. J. Staes ◽  
T. L. Schlenker ◽  
I. Risk ◽  
K. G. Cannon ◽  
H. Harris ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Acute Hepatitis A ◽  
Sources Of Infection
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