scholarly journals Normo-Calcemic Tetany in a Patient with Hypokalemic Periodic Paralysis of Sjogren’s Syndrome: Neuromuscular Excitability Secondary to the ‘Forgotten Cation’

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Urmila Anandh ◽  
Pradeep Mishra ◽  
Hilal Malla
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Ventilatory Support ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Periodic Paralysis ◽  
Neuromuscular Excitability ◽  
Carpopedal Spasm ◽  
Sjögren‘S Syndrome

: A young lady, a known case of Sjogren’s syndrome, presented to our hospital with hypokalemic flaccid paralysis requiring ventilatory support. She was investigated and found to have severe hypokalemia and metabolic acidosis. During her hospitalization, she had severe persistent carpopedal spasm with normal ionized calcium. Following further evaluation, there was evidence of hypomagnesemia. The spasms were improved after her hypomagnesemia was corrected. This case report illustrate the role of hypomagnesemia in neurological abnormalities in hospitalized patients.

scholarly journals A Crucial Role of RORγt in the Development of Spontaneous Sialadenitis-like Sjögren’s Syndrome

2014 ◽  
Vol 194 (1) ◽  
pp. 56-67 ◽  
Author(s):  
Mana Iizuka ◽  
Hiroto Tsuboi ◽  
Naomi Matsuo ◽  
Hiromitsu Asashima ◽  
Tomoya Hirota ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Crucial Role ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Local and Systemic IKKεand NF-κB Signaling Associated with Sjögren’s Syndrome Immunopathogenesis

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Weiqian Chen ◽  
Jin Lin ◽  
Heng Cao ◽  
Danyi Xu ◽  
Bei Xu ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Mononuclear Cells ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Minor Salivary Glands ◽  
Healthy Individuals ◽  
Peripheral Blood Mononuclear ◽  
Sjögren‘S Syndrome

The activated NF-κB signaling pathway plays an important role in pathogenesis of primary Sjögren’s syndrome (pSS). The inhibitor ofκB (IκB) kinase (IKK) family such as IKKα, IKKβ, IKKγ, and IKKε, is required for this signaling. Our aim was to investigate the role of IKKα/β/γ/εin patients with untreated pSS. In minor salivary glands from pSS patients, phosphorylated IKKε(pIKKε), pIκBα, and pNF-κB p65 (p-p65) were highly expressed in ductal epithelium and infiltrating mononuclear cells by immunohistochemistry, compared to healthy individuals. pIKKα/βand pIKKγwere both negative. And pIKKεpositively related to expression of p-p65. Furthermore, pIKKεand p-p65 expression significantly correlated with biopsy focus score and overall disease activity. Meanwhile, in peripheral blood mononuclear cells from pSS patients, pIKKε, total IKKε, pIKKα/β, and p-p65 were significantly increased by western blot, compared to healthy controls. However, there was no difference in IKKγand IκBαbetween pSS patients and healthy individuals. These results demonstrated an abnormality of IKKε, IκBα, and NF-κB in pSS, suggesting a potential target of treatment for pSS based on the downregulation of IKKεexpression and deregulation of NF-κB pathway.

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